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Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer’s disease

  • B. L. Fiebich
  • M. Hüll
  • K. Lieb
  • G. Schumann
  • M. Berger
  • J. Bauer
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 54)

Summary

Prostaglandins (PGs) and cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), have been implicated in the etiopathology of various inflammatory and degenerative disorders, including Alzheimer’s disease (AD). Previously, we detected the presence of IL-6 in cortices of AD patients. On the other hand, non-steroidal antiinflammatory drugs (NSAIDs), potent inhibitors of prostaglandin synthesis, have been shown to be beneficial in the treatment of AD. Until now, it remained unclear whether and how these two observations were functionally connected. Here, we show that PGs are able to induce IL-6 synthesis in a human astrocytoma cell line. PGE1 and PGE2, but not PGD2 and PGF, led to a rapid and transient induction of astrocytic IL-6 mRNA, followed by IL-6 protein synthesis. Furthermore, PGE2 potentiated IL-1β-induced IL-6 mRNA synthesis. These results suggest a possible link between the release of PGs from activated microglia and the astrocytic synthesis of IL-6, which itself may affect neuronal cells, as hypothesized for Alzheimer’s disease. Finally we demonstrate that microglia are a strong source of PGE2 synthesis indicating that these cells may act as the origin of the pathogenic cascade.

Keywords

Microglial Cell Arachidonic Acid Metabolism Actin cDNA Prostaglandin Leukot Essent Fatty Acid Human Astrocytoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1998

Authors and Affiliations

  • B. L. Fiebich
    • 1
  • M. Hüll
    • 1
  • K. Lieb
    • 1
  • G. Schumann
    • 1
  • M. Berger
    • 1
  • J. Bauer
    • 1
  1. 1.Department of PsychiatryUniversity of Freiburg Medical SchoolFreiburgFederal Republic of Germany

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