Neuronal anion exchange proteins in Alzheimer’s disease pathology

  • G. J. C. G. M. Bosman
  • K. Renkawek
  • F. P. A. Van Workum
  • I. G. P. Bartholomeus
  • S. Marini
  • W. J. De Grip
Conference paper
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 54)


Anion exchange (AE) proteins are present in human neurons in the brain. Immunohistochemical data indicate that their apparent expression level increases with age, and especially with degeneration in Alzheimer’s disease-affected brain areas. The increase in immunoreactivity is probably caused by changes in AE structure that lead to an increased accessibility of hitherto hidden epitopes. These epitopes correspond to regions in the membrane domain that are involved in generation of senescent cell-specific antigen from AE1 in aging erythrocytes. Elucidation of the molecular nature of these changes and the underlying mechanisms will lead to insight in the processes that govern aging- and degeneration-associated perturbation of membrane integrity. The functional consequences of changes in AE structure may range from acidosis and disturbance of cytoskeleton integrity to untimely or impaired recognition of neurons by microglia.


Anion Exchange Neurobiol Aging Alzheimer Hippocampus Large Pyramidal Neuron Aging Erythrocyte 


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Copyright information

© Springer-Verlag/Wien 1998

Authors and Affiliations

  • G. J. C. G. M. Bosman
    • 1
  • K. Renkawek
    • 2
  • F. P. A. Van Workum
    • 2
  • I. G. P. Bartholomeus
    • 1
  • S. Marini
    • 3
  • W. J. De Grip
    • 1
  1. 1.Department of Biochemistry, Institute of Neurology, Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Research Laboratory of Morphological Neurology, Institute of Neurology, Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  3. 3.Department of Experimental Medicine and BiochemistryUniversity “Tor Vergata”RomeItaly

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