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Risk factors for Azheimer’s disease during aging. Impacts of glucose/energy metabolism

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Alzheimer’s Disease — From Basic Research to Clinical Applications

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 54))

Summary

The majority of Alzheimer patients is of late onset and with unknown etiology. However, several risk factors have been discussed among which age is a most important one with respect to sporadic Alzheimer type dementia (SDAT). Age includes changes in brain glucose/energy metabolism, in both insulin and acetylcholine signal transduction and in membrane function to name the functionally most important ones. Variations in these parameters can form the basis for ongoing changes in terms of the principle of self-organized criticality inducing catastrophic i.e. disease processes. Subsequent abnormalities at the cellular and molecular levels may develop including the formation of both amyloid plaques and neurofibrillary tangles.

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Author information

Authors and Affiliations

  1. Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220/221, D-69120, Heidelberg, Federal Republic of Germany

    Prof. Dr. S. Hoyer

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  1. Prof. Dr. S. Hoyer
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Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie, Universität Leipzig, Bundesrepublik Deutschland

    H.-J. Gertz

  2. Paul-Flechsig-Institut für Hirnforschung, Universität Leipzig, Bundesrepublik Deutschland

    Th. Arendt

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© 1998 Springer-Verlag/Wien

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Hoyer, S. (1998). Risk factors for Azheimer’s disease during aging. Impacts of glucose/energy metabolism. In: Gertz, HJ., Arendt, T. (eds) Alzheimer’s Disease — From Basic Research to Clinical Applications. Journal of Neural Transmission. Supplementa, vol 54. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7508-8_18

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  • DOI: https://doi.org/10.1007/978-3-7091-7508-8_18

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83112-0

  • Online ISBN: 978-3-7091-7508-8

  • eBook Packages: Springer Book Archive

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