Risk factors for Azheimer’s disease during aging. Impacts of glucose/energy metabolism

  • S. Hoyer
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 54)


The majority of Alzheimer patients is of late onset and with unknown etiology. However, several risk factors have been discussed among which age is a most important one with respect to sporadic Alzheimer type dementia (SDAT). Age includes changes in brain glucose/energy metabolism, in both insulin and acetylcholine signal transduction and in membrane function to name the functionally most important ones. Variations in these parameters can form the basis for ongoing changes in terms of the principle of self-organized criticality inducing catastrophic i.e. disease processes. Subsequent abnormalities at the cellular and molecular levels may develop including the formation of both amyloid plaques and neurofibrillary tangles.


Amyloid Precursor Protein Advance Glycation Endproducts Neurobiol Aging Glucose Transport Protein Acetylcholine Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 1998

Authors and Affiliations

  • S. Hoyer
    • 1
  1. 1.Department of Pathochemistry and General NeurochemistryUniversity of HeidelbergHeidelbergFederal Republic of Germany

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