Alzheimer’s disease: the size of the problem, clinical manifestation and heterogeneity

  • H. Förstl
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 54)


Age is the major demographic risk factor for the development of Alzheimer’s disease (AD) and the ageing of our society has contributed to the growing importance of AD. The problem of AD has been tackled from numerous clinical and scientific angles. The traditional clinico-pathological disease concept, which relies on the manifestation of a dementia syndrome and the elimination of other relevant systemic and brain diseases for a diagnosis of AD, accommodates a number of genetically and clinically heterogenous conditions, but cannot promote our understanding of the preclinical pathogenetic processes and their interaction. If new molecular biological discoveries cannot be integrated with this traditional clinico-pathological model, it may have outlived its usefulness.


Mild Cognitive Impairment Senile Dementia Morbidity Risk Dementia Syndrome Progressive Paralysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 1998

Authors and Affiliations

  • H. Förstl
    • 1
  1. 1.Department of PsychiatryTechnical UniversityMünchenFederal Republic of Germany

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