Pharmacology and neuroprotective properties of rasagiline

  • J. P. M. Finberg
  • I. Lamensdorf
  • J. W. Commissiong
  • M. B. H. Youdim
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 48)


Rasagiline [R(+)-N-propargyl-1-aminoindane] is a selective irreversible inhibitor of MAO-B which is not metabolised to amphetamine-like derivatives. Like deprenyl, when given to rats in a dose selective for inhibition of MAO-B, it does not affect striatal extracellular fluid dopamine levels, but when administered chronically (21 days) it increased striatal microdialysate dopamine without reduction in deaminated metabolites. Similarly to deprenyl, rasagiline (10-6M) increased the percentage of tyrosine hydroxylase positive cells in a primary culture of rat fetal mesencephalic cells (6 days in culture). Rasagiline, but not deprenyl, also increased the number of neurons per field in this organotypic culture.


Tyrosine Hydroxylase Monoamine Oxidase Prop Argyl Dopaminergic Cell Microdialysis Probe 


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Copyright information

© Springer-Verlag/Wien 1996

Authors and Affiliations

  • J. P. M. Finberg
    • 1
  • I. Lamensdorf
    • 1
  • J. W. Commissiong
    • 2
  • M. B. H. Youdim
    • 1
    • 3
  1. 1.Pharmacology UnitRappaport Faculty of Medicine, TechnionHaifaIsrael
  2. 2.USA
  3. 3.Rappaport Family Research InstituteHaifaIsrael

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