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The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (−)-deprenyl research

  • K. Magyar
  • B. Szende
  • J. Lengyel
  • K. Tekes
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 48)

Summary

(−)-deprenyl cannot be considered as a simple, selective inhibitor of MAO-B. It increases the dopaminergic tone in the central nervous system by a complex mechanism. The MAO-B inhibition could result in a potentiation of the effect and the reduction of the dose of L-dopa, including the restoration of the sensitivity to L-dopa treatment, when the response to the drug has already been diminished or lost. Pre-treatment with (−)deprenyl prevent the effect of neurotoxins like MPTP, 6-hydroxydopamine, DSP-4, AF64A by inhibiting the conversion of the pretoxin to toxin, or by inhibiting the neuronal reuptake mechanisms, or the combination of the two processes. However, other effects of the inhibitor cannot be ruled out. (−)-deprenyl, but not its (+)-enantiomer, proved to be a potent inhibitor of programmed cell death (apoptosis) of PC12 cells and that of human melanoma cells, in a concentration which does not induce MAO-B inhibition. The activity of MAO-B increases with age and the age related changes led to an overproduction of neurotoxic agents. The inhibition of the enzyme activity can play a preventive role against neurodegenerative brain disorders. The most widely used MAO-B inhibitor in the therapy is (−)-deprenyl and it lacks the “cheese reaction”. The complex mechanism for the lack of the former effect is not fully known.

Keywords

PC12 Cell Monoamine Oxidase Cheese Effect Deprenyl Treatment Neurodegenerative Brain Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1996

Authors and Affiliations

  • K. Magyar
    • 1
  • B. Szende
    • 2
  • J. Lengyel
    • 3
  • K. Tekes
    • 1
  1. 1.Department of PharmacodynamicsSemmelweis University of MedicineBudapest VIIIHungary
  2. 2.1st Department of Pathology and Experimental Cancer ResearchHungary
  3. 3.Central Isotope LaboratorySemmelweis University of MedicineBudapestHungary

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