Genotypes of hepatitis C virus isolates from different parts of the world

  • E. Schreier
  • M. Roggendorf
  • G. Driesel
  • M. Höhne
  • S. Viazov
Part of the Archives of Virology Supplement II book series (ARCHIVES SUPPL, volume 11)


Hepatitis C virus (HCV) causes most cases of posttransfusion non-A, non-B hepatitis. HCV isolates were classified by their genetic relatedness into at least six genotypes and a series of subtypes. Methods for typing included amplification of certain genomic regions using universal or type/subtype specific primers, restriction fragment length polymorphism analysis, differential hybridization, nucleotide sequencing, and serologic genotyping. HCV genotypes and their subtypes coexist in various geographic locations but show different prevalences. The identification of genotypes/subtypes is useful for studies on the molecular epidemiology and pathogenesis of HCV infection.


Line Probe Assay 


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Copyright information

© Springer-Verlag/Wien 1996

Authors and Affiliations

  • E. Schreier
    • 1
  • M. Roggendorf
    • 2
  • G. Driesel
    • 1
  • M. Höhne
    • 1
  • S. Viazov
    • 3
  1. 1.Robert Koch-InstituteBerlinFederal Republic of Germany
  2. 2.Institute of VirologyUniversity of EssenEssenFederal Republic of Germany
  3. 3.Ivanovsky Institute of VirologyMoscowRussia

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