The basic principles of immunological phenomena have developed to a point where antigen-antibody reactions are an integral part of fundamental biochemistry and an important tool for the physical chemist. This unique position of immunochemistry is due to the work of a large group of investigators during the past fifty years but particularly to Landsteiner for studies of specificity, Heidelberger and colleagues for the development and emphasis of quantitative aspects of immunochemical reactions, and Pauling and his collaborators for the development and investigation of stimulating theoretical concepts. It is somewhat paradoxical that at present these studies have contributed as much if not more to our understanding of the physical nature of proteins than to an understanding of immunity mechanisms. Many of our present concepts may be erroneous or oversimplified but nevertheless furnish a useful basis for investigation of biological phenomena and reactions of proteins.


Diphtheria Toxin Antibody Molecule Simple Substance Serological Property Specific Precipitate 
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© Wien · Springer-Verlag 1952

Authors and Affiliations

  • Dan H. Campbell
    • 1
  • N. Bulman
    • 1
  1. 1.PasadenaUSA

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