The Polyene Antifungal Antibiotics

  • W. Oroshnik
  • A. D. Mebane
Part of the Fortschritte Der Chemie Organischer Naturstoffe book series (FORTCHEMIE (closed), volume 21)


During the early 1950’s there appeared reports, from time to time of the presence among the products elaborated by actinomycetes of antifungal antibiotics which exhibited very similar and very characteristic multipeaked ultraviolet absorption spectra. In 1954, with a good number of examples on record, these spectra were analyzed and identified as those of straight-chain conjugated polyenes, comprising tetraenes, pentaenes, hexaenes and heptaenes (85, 130). These antibiotics have since been commonly referred to as the polyene antifungal antibiotics to distinguish them from a host of other miscellaneous antibiotics which also have antifungal properties. Within the next few years, reports of discoveries of new members of this class multiplied rapidly, and almost sixty are now known.


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Copyright information

© Springer-Verlag/Wien 1963

Authors and Affiliations

  • W. Oroshnik
    • 1
  • A. D. Mebane
    • 2
  1. 1.CliftonUSA
  2. 2.RaritanUSA

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