The concluding sentence of an earlier article on hemoglobin in 1959 (213) stated that “Many years of effort by many investigators will no doubt be required before the last amino acid residue [of hemoglobin] is placed in the sequence and before the nature of the hemeglobin linkage becomes apparent, but it is not too much to expect that this goal will be achieved”. Prophecy clearly is an uncertain art: within three years after the sentence was written, the complete amino acid sequence of human hemoglobins A and F was known and the hemeglobin linkage appeared to be clearly defined. Yet a grain of truth was in the statement. The man-years of effort that were required to attain the goal within so short a time are not easily calculated.


Tryptic Peptide Heme Group Fetal Hemoglobin Human Hemoglobin Bovine Hemoglobin 
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Copyright information

© Springer-Verlag/Wien 1965

Authors and Affiliations

  • Walter A. Schroeder
    • 1
  • Richard T. Jones
    • 2
  1. 1.PasadenaUSA
  2. 2.PortlandUSA

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