The discovery (39) and use of penicillin as the first antibiotic ushered in a new era of modern medicine. Despite the discovery and introduction into medical practice of many other antibiotics, this family of antibacterial substances (1) maintains a dominant position in the treatment of bacteria-caused diseases (29, 138). One of the most important advances in this area within the last ten years has been the discovery of the cephalosporin antibiotics and their use in clinical medicine (1, 146).


Total Synthesis Fusidic Acid Raney Nickel Tetrahedron Letter Cephalosporin Antibiotic 


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Copyright information

© Springer-Verlag/Wien 1970

Authors and Affiliations

  • R. B. Morin
    • 1
  • B. G. Jackson
    • 1
  1. 1.MadisonUSA

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