Glucagon is a polypeptide hormone secreted by the α2-cells of the pancreas in response to a variety of stimuli. The hormone exhibits many biologic effects in several different target organs, but it is best known for its role in the homeostatic control of blood glucose. Many of the actions of glucagon result from interaction with cell membrane-bound adenyl cyclase, thus increasing the intracellular conversion of ATP to adenosine 3′-5′-phosphate (cyclic AMP), the “second messenger”.


Adenyl Cyclase Glucagon Secretion Optical Rotatory Dispersion Pancreatic Glucagon Dipeptidyl Aminopeptidase 
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© Springer-Verlag/Wien 1970

Authors and Affiliations

  • W. Bromer
    • 1
  1. 1.IndianapolisUSA

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