Non-operative Management of Intracranial Hypertension

  • N. Lundberg
  • Å. Kjällquist
  • G. Kullberg
  • U. Pontén
  • G. Sundbärg
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 1)


The brain, by being encased in a container with rigid walls, is unique among the organs of the human body. The restricted ability of the intracranial contents to expand implies that the intracranial pressure (ICP) is a parameter of central importance for the intracranial dynamics.


Cerebral Blood Flow Intracranial Pressure Brain Edema Intracranial Hypertension Cerebral Perfusion Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adams, R. W., Gronert, G. A., Sundt, T. M., and Michenfelder, J. D., 1972: Halothane, hypocapnia and cerebrospinal fluid pressure in neurosurgery. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 320–325. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  2. Alexander, S. C., Cohen, P. J., Wollman, H., Smith, T. C., Reivich, M., and van der Molen, R. A., 1965: Cerebral carbohydrate metabolism during hypocarbia in man. Anesthesiology 26, 624–632.PubMedCrossRefGoogle Scholar
  3. Ames, A. III, Wright, R. L., Kowada, M., Thurston, J. M., and Majno, G., 1968: Cerebral ischaemia. II. The no-reflow phenomenon. Amer. J. Path. 52, 437–454.PubMedGoogle Scholar
  4. Antoni, N., 1946: Pressure curves from the cerebrospinal fluid. Acta med. seand., suppl. 170, pp. 439–462.Google Scholar
  5. Becker, D. P., and Vries, J. K., 1972: The alleviation of increased intracranial pressure by the chronic administration of osmotic agents. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 309–315. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  6. Behring, E. A., Jr., 1951: A simplified apparatus for constant ventricular drainage. J. Neurosurg. 8, 450–452.CrossRefGoogle Scholar
  7. Avman, N., 1960: The use of hypertonic urea solutions in hypothermia. J. Neurosurg. 17, 1073–1082.CrossRefGoogle Scholar
  8. Taren, J. A., McMurrey, J..D., and Bernard, W. F., 1956: Studies on hypothermia in monkeys. II. The effect of hypothermia on the general physiology and cerebral metabolism of monkeys in the hypothermic state. Surg. Gynec. Obstet. 102, 134–138.PubMedGoogle Scholar
  9. Berman, I. R., and Ducker, T. B., 1969: Pulmonary, somatic and splanchnic circulatory responses to increased intracranial pressure. Ann. Surg. 169, 210216.PubMedCrossRefGoogle Scholar
  10. Bigelow, W. G., Lindsay, W. K., Harrison, R. C., Gordon, R. A., and Greenwood, W. F., 1950: Oxygen transport and utilization in dogs at low body temperatures. Amer. J. Physiol. 160, 125–137.PubMedGoogle Scholar
  11. Bloch, M., 1967: Cerebral effects of rewarming following prolonged hypothermia: significance for the management of severe cranio-cerebral injury and acute pyrexia. Brain 90, 769–783.PubMedCrossRefGoogle Scholar
  12. Boerema, I., Wildschut, A., Schmidt, W. J. H., and Broekhuysen, L., 1951: Experimental researches into hypothermia as an aid in the surgery of the heart. Preliminary communication. Arch. chir. neerl. 3, 25–34.PubMedGoogle Scholar
  13. Botterell, E. H., Lougheed, W. M., Scott, J. W., and Vandewater, S. L., 1956: Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms. J. Neurosurg. 13, 1–42.PubMedCrossRefGoogle Scholar
  14. Bouzarth, W. F., and Madow, L., 1966: A technique for immediate hypothermia and arteriography after cranial trauma. J. Trauma 6, 56–60.PubMedCrossRefGoogle Scholar
  15. Bozza-Marrubini, M., Rossanda, M., and Tretola, L., 1964: The role of artificial hyperventilation in the control of brain tension during neurosurgical operations. Brit. J. Anaesth. 36, 415.CrossRefGoogle Scholar
  16. Brock, M., and Dietz, H., 1972: Intracranial pressure. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  17. Brown, F. K., 1956: Cardiovascular effects of acutely raised intracranial pressure. Amer. J. Physiol. 185, 510–514.PubMedGoogle Scholar
  18. Bruce, D. A., Langfitt, T. W., Miller, J. D., Schutz, H., Yapalahti, M. P., Stanek, A., Goldberg, H. I., 1973: Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J. Neurosurg. 38, 131–144.PubMedCrossRefGoogle Scholar
  19. Buekell, M., 1964: Blood changes on intravenous administration of mannitol or urea for reduction of intracranial pressure in neurosurgical patients. Clin. Sci. 27, 223–227.Google Scholar
  20. Cantore, G. P., Guidetti, B., and Virno, M., 1964: Oral glycerol for the reduction of intracranial pressure. J. Neurosurg. 21, 278–283.PubMedCrossRefGoogle Scholar
  21. Connor, R. C. R., 1968: Heart damage associated with intracranial lesions. Brit. Med. J. 3, 29–31.PubMedCrossRefGoogle Scholar
  22. Cooper, R., and Hulme, A., 1966: Intracranial pressure and related phenomena during sleep. J. Neurol. Neurosurg. Psychiat. 29, 564–570.CrossRefGoogle Scholar
  23. Cushing, H., 1902: Some experimental and clinical observations concerning states of increased intracranial tension. Amer. J. med. Sei. 124, 375–400.CrossRefGoogle Scholar
  24. Cutler, R.W. P., Page, L., Galicich, J., and Watters, G. V., 1968: Formation and absorption of cerebrospinal fluid in man. Brain 91, 707–720.PubMedCrossRefGoogle Scholar
  25. Dandy, W. E., and Blackfan, K. D., 1914: Internal hydrocephalus. An experimental clinical and pathological study. Amer. J. Dis. Child. 8, 406–482.Google Scholar
  26. Davson, H., 1967: Physiology of the cerebrospinal fluid. London: J. and A. Churchill.Google Scholar
  27. Hollingsworth, G., and Segal, M. B., 1970: The mechanism of drainage of the cerebrospinal fluid. Brain 93, 665–678.PubMedCrossRefGoogle Scholar
  28. Ducker, T. B., 1968: Increased intracranial pressure and pulmonary edema. Part I: Clinical study of 11 patients. J. Neurosurg. 28, 112–117.PubMedCrossRefGoogle Scholar
  29. Evans, J. P., Espey, F. F., Kristoff, F. V., Kimbell, F. D., and Ryder, H. W., 1951: Experimental and clinical observations on rising intracranial pressure. Arch. Surg. 63, 107–114.Google Scholar
  30. Fitch, W., and McDowall, D. G., 1971: Effect of halothane on intracranial pressure gradients in the presence of intracranial space-occupying lesions. Brit. J. Anaesth. 43, 904–912.PubMedCrossRefGoogle Scholar
  31. Fog, M., 1933: Influence of intracranial hypertension upon the cerebral circulation. Acta psychiat. scand. 8, 191–198.CrossRefGoogle Scholar
  32. Freeman, N.E.,and Jeffers, W.A. 1939–1940: Effects of progressive sympathectomy on hypertension produces by increased intracranial pressure. Amer. J. Physiol. 128, 662–671.Google Scholar
  33. French, L. A., and Galicich, J. H., 1964: The use of steroids for control of cerebral edema. Clin. Neurosurg. 10, 212–223.PubMedGoogle Scholar
  34. Galicich, J. H., and French, L. A., 1961: Use of dexamethasone in the treatment of cerebral edema resulting from brain tumours and brain surgery. Amer. Practit. 12, 169–174.Google Scholar
  35. Galle, P., und Staudacher, M., 1968: Einfluß entwässernder Medikamente auf den Liquordruck beim Schädelhirntrauma. Med. klin. 63, 16–20.PubMedGoogle Scholar
  36. Gänshirt, H., Hirsch, H., Krenkel, W., Schneider, M., und Zylka, W., 1954: Über den Einfluß der Temperatursenkung auf die Erholungsfähigkeit des Warmblütergehirns. Arch. exp. Path. Pharmak. 222, 431–449.Google Scholar
  37. Goluboff, B., Shenkin, H. A., Haft, H., 1964: The effects of mannitol and urea on cerebral hemodynamics and cerebrospinal fluid pressure. Neurology 14, 891–898.PubMedGoogle Scholar
  38. Gordon, E., 1971: Controlled respiration in the management of patients with traumatic brain injuries. Acta anaesth. scand. 15, 193–208.PubMedCrossRefGoogle Scholar
  39. Granholm, L., Lukjanova, L., and Siesjö, B. K., 1969: The effect of marked hyperventilation upon tissue levels of NADH, lactate, pyruvate, phosphocreatine, and adenosine phosphates of rat brain. Acta physiol. scand. 77, 179–190.PubMedCrossRefGoogle Scholar
  40. Greenfield, J. C., and Tindall, G. T., 1965: Effect of acute increase in intracranial pressure on blood flow in the internal carotid artery of man. J. clin. Invest. 44, 1343–1351.PubMedCrossRefGoogle Scholar
  41. Grote, W., und Wüllenweber, R., 1960: Über “Liquordruekkrisen”— spontane Druckschwankungen bei intraeraniellen Liquorpassagestörungen. Acta neurochir. 9, 125–138.CrossRefGoogle Scholar
  42. Guttman, L., 1936: Physiologie und Pathologie der Liquormechanik und Liquor-dynamik. In: Handbuch der Neurologie, O. Bumke und O. Foerster (Eds.), pp. 1–107. Berlin: Springer.Google Scholar
  43. Hawkins, W. E., and Glower, B. R., 1971: Myocardial damage after head trauma and simulated intracranial haemorrhage in mice: the role of the autonomic nervous system. Cardio vase. Res. 5, 524–529.CrossRefGoogle Scholar
  44. Hayakawa, T., Kanai, N., Kuroda, R., Yamada, R., and Mogami, H., 1971: Response of cerebrospinal fluid pressure to hyperbaric oxygenation. J. Neurol. Neurosurg. Psychiat. 34, 580–586.PubMedCrossRefGoogle Scholar
  45. Hedges, T. R., Weinstein, J. D., Kassell, N. F., and Stein, S., 1964: Cerebrovascular responses to increased intracranial pressure. J. Neurosurg. 21, 292–297.PubMedCrossRefGoogle Scholar
  46. Hekmatpanah, J., 1970: Cerebral circulation and perfusion in experimental increased intracranial pressure. J. Neurosurg. 32, 21–29.PubMedCrossRefGoogle Scholar
  47. Henriksen, H. T., and Jorgensen, P. B., 1973: The effect of nitrous oxide on intracranial pressure in patients with intracranial disorders. Brit. J. Anaesth. 45, 486–492.PubMedCrossRefGoogle Scholar
  48. Hodgson, J. S., 1928: Combined ventricular and lumbar puncture in diagnosis of brain tumour; further studies. J. Amer. med. Ass. 90, 1524–1525.Google Scholar
  49. Hoff, H. E., and Breckenridge, C. G., 1954: Intrinsic mechanisms in periodic breathing. Arch. Neurol, and Psychiat. 72, 11–42.Google Scholar
  50. Ingraham, F. C., and Campbell, J. B., 1941: An apparatus for closed drainage of the ventricular system. Ann. Surg. 114, 1096–1098.CrossRefGoogle Scholar
  51. Ingvar, D. H., and Lundberg, N., 1961: Paroxysmal symptoms in intracranial hypertension, studied with ventricular fluid pressure recording and electroencephalography. Brain 84, 446–459.CrossRefGoogle Scholar
  52. Jacobson, I., Harper, A.M., and McDowall, D. G., 1964: The effect of oxygen at 1 and 2 athmospheres on the blood flow and oxygen uptake of cerebral cortex. Surg. Gynec. Obstet. 119, 737–742.PubMedGoogle Scholar
  53. Janny, P., 1950: La pression intracranienne chez l’homme. Thèse: Faculté de Medicine, Paris. Reprinted: Clermont-Reproduetion, Clermont-Ferrand, 1972.Google Scholar
  54. Jouan, J. P., Janny, L., Gourgand, M., and Gueit, U.M., 1972a: A statistical approach to long-term monitoring of intracranial pressure. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 59–64. Berlin-Heidelberg-New York: Springer.Google Scholar
  55. Lapalus, J., Chabannes, J., et Montrieul, B., 1972b: Étude comparative clinique et manométrique des solutions hypertoniques et des corticoïdes dans le traitement de l’hypertension intra-cranienne. Neurochirurgie 18, 121–136.PubMedGoogle Scholar
  56. Javid, M., and Settlage, P., 1956: Effect of urea on cerebrospinal fluid pressure in human subjects. Preliminary report. J. Amer. med. Ass. 160, 943–949.Google Scholar
  57. Javid, M., and Settlage, P., 1957: Clinical use of urea for reduction of intracranial pressure. Trans. Amer. neurol. Ass. 151–153.Google Scholar
  58. Anderson, J., 1958: Observations on the use of urea in rhesus monkeys. Surg. Forum 9, 686–690.PubMedGoogle Scholar
  59. Jefferson, G., and Johnson, R. T., 1950: The cause of loss of consciousness in posterior fossa compressions. Folia psychiat. neerl. 53, 306–319.PubMedGoogle Scholar
  60. Jennett, W. B., and Johnston, I. H., 1972: The uses of intracranial pressure monitoring in clinical management. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 353–356. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  61. Jeppsson, P. G., and Nielsen, K., 1955: The effect of hypothermia on lesions of the blood-brain barrier produced by Umbradil. In: Proc. 2nd int. Congr. Neuropath., London 1955, pp. 411–413. Amsterdam: Excerpta Medica Foundation.Google Scholar
  62. Johnson, R. H., 1972: Cerebrospinal fluid. In: Scientific Foundations of Neurology. M. Critchley, J. L. O’Leary and B. Jennett (Eds.), pp. 281–288. London: WiF. iam Heinemann Medical Books.Google Scholar
  63. Johnston, I. H., Paterson, A., Harper, A. M., and Jennett, W. B., 1972: The effect of mannitol on intracranial pressure and cerebral blood flow. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 176–180. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  64. Key, A., und Retzius, G., 1875: Anatomie des Nervensystems und des Bindegewebes, Vol. I. Stockholm: P. A. Nordstedt and Söner.Google Scholar
  65. Kjällquist, Å., Lundberg, N., and Pontén, U, 1964: Respiratory and cardiovascular changes during rapid spontaneous variations of ventricular fluid pressure in patients with intracranial hypertension. Acta neurol. scand. 40, 291–317.Google Scholar
  66. Klatzo, I., 1972: Pathophysiological aspects of brain edema. In: Steroids and Brain Edema, H. J. Reulen and K. Schürmann (Eds.), pp. 1–7. Berlin-Heidelberg- New York: Springer.Google Scholar
  67. Wisniewski, H., Steinwall, O., and Streicher, E., 1967: Dynamics of cold injury edema. In: Brain Edema, I. Klatzo and F. Seitelberger (Eds.), pp. 554–563. Berlin-Heidelberg-New York: Springer.Google Scholar
  68. Kofman, S., Garvin, J. S., and Nagamani, D., 1957: Treatment of cerebral metastases from breast carcinoma with prednisolone. J. Amer. med. Ass. 163, 1473–1476.Google Scholar
  69. Kullberg, G., 1972: A method for statistical analysis of intracranial pressure recordings. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 65–69. Berlin - Heidelberg-New York: Springer.CrossRefGoogle Scholar
  70. West, K. A., 1965: Influence of corticosteroids on the ventricular fluid pressure. Acta neurol. scand. 41, Suppl. 13 /11, 445–452.Google Scholar
  71. Sundbärg, G., 1970: A method for the automatic statistical analysis of intracranial pressure recordings. Proceedings of Scand. Neurosurg. Soc. 22nd Ann. Meeting, Stockholm, 1970. Acta neurol. scand. 46, 631.Google Scholar
  72. Kusske, J. A., Turner, P. T., Ojemann, G. A., and Harris, A. B., 1973: Ventriculostomy for the treatment of acute hydrocephalus following subarachnoid hemorrhage. J. Neurosurg. 38, 591–595.PubMedCrossRefGoogle Scholar
  73. Laborit, H., et Huguenard, P., 1951: L’hibernation artifieielle par moyens pharmaco- dynamiques et physiques. Presse med. 59, 1329.PubMedGoogle Scholar
  74. Langfitt, T. W., 1973: Increased intracranial pressure. In: Neurological Surgery, Vol. I, J. R. Youmans (Ed.), pp. 443–495. Philadelphia-London-Toronto: W. B. Saunders Company.Google Scholar
  75. Weinstein, J. D., Kassel, N. F., and Simeone, F. A., 1964: Transmission of increased intracranial pressure. I. Within the craniospinal axis. J. Neurosurg. 21, 989–997.PubMedCrossRefGoogle Scholar
  76. Weinstein, J. D., Kassel, N. F., and Simeone, F. A., 1965: Cerebral vasomotor paralysis produced by intracranial hypertension. Neurology (Minneap.) 15, 622–641.Google Scholar
  77. Weinstein, J. D., Kassel, N. F., and Simeone, F. A., 1966: Vascular factors in head injury. In: Head Injury, Conference Proceedings, W. F. Caveness, and A. E. Walker (Eds.), pp. 172–194. Philadelphia- Toronto: J. B. Lippincott Company.Google Scholar
  78. Jackson, J. L. F., 1967: Contributions of trauma, anoxia, and arterial hypertension to experimental acute brain swelling. Trans. Amer. Neurol. Ass. 92, 257–259.PubMedGoogle Scholar
  79. Lassen, N. A., 1964: Autoregulation of cerebral blood flow. Circulat. Res. Vols. 14 and 15, 1: 201–204.Google Scholar
  80. Lassen, N. A., 1966: The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localized within the brain. Lancet 2, 1113.PubMedCrossRefGoogle Scholar
  81. Lazorthes, G., and Campan, L., 1958: Hypothermia in the treatment of craniocerebral traumatism. J. Neurosurg. 15, 162–167.PubMedCrossRefGoogle Scholar
  82. Löfgren, J., 1973: Pressure-volume relationships of the cerebrospinal fluid system. An experimental analysis in dogs. Thesis. Göteborg: Elanders Boktryckeri AB.Google Scholar
  83. Lorenzo, A. V., Page, L. K., and Watters, G. V., 1970: Relationship between cerebrospinal fluid formation, absorption and pressure in human hydrocephalus. Brain 93, 679–692.PubMedCrossRefGoogle Scholar
  84. Lundberg, N. 1960: Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta psychiat. scand. 36, Suppl. 149Google Scholar
  85. Lundberg, N., 1969: Results of total and subtotal removal of acoustic neuromas. In: Disorders of the skull base region. Nobel Symposium 10, C.-A. Hamberger, and J. Wersäll (Eds.), pp. 113–119. Stockholm: Almqvist and Wiksell.Google Scholar
  86. Lundberg, N., 1972: Monitoring of the intracranial pressure. In: Scientific foundations of neurology, M. Critchley, J. L. O’Leary, and B. Jennett (Eds.), pp. 356– 371. London: William Heinemann Medical Books Ltd.Google Scholar
  87. Lundberg, N., Nielsen, K. C., and Nilsson, E., 1956: Deep hypothermia in intracranial surgery. J. Neurosurg. 13, 235–247.PubMedCrossRefGoogle Scholar
  88. Lundberg, N., Kjällquist, Å., and Bien, C., 1959: Reduction of increased intracranial pressure by hyperventilation. A therapeutic aid in neurological surgery. Acta psychiat. scand. 34, Suppl. 139.Google Scholar
  89. Nielsen, K. C., 1959: Hypothermia in the treatment of cerebral tumours. In: First international congress of neurological surgery, Brussels 1957, pp. 52–60. London: Pergamon Press.Google Scholar
  90. Pontén, U, 1963: Some observations on postoperative ventricular fluid pressure. Acta neurol. scand. 39, 264–265.Google Scholar
  91. Troupp, H., and Lorin, H., 1965: Continuous recording of the ventricular-fluid pressure in patients with severe acute traumatic brain injury: a preliminary report. J. Neurosurg. 22, 581–590.PubMedCrossRefGoogle Scholar
  92. West, K. A., 1965: Leakage as a source of error in measurement of the cerebrospinal fluid pressure by lumbar puncture. Acta neurol. scand. 41, Suppl. 13, 115–121.Google Scholar
  93. Cronqvist, S., and Kjällquist, Å., 1968: Clinical investigations on interrelations between intracranial pressure and intracranial hemodynamics. In: Cerebral circulation. Progress in brain research, Vol. 30, W. Luyendijk (Ed.), pp. 70–75. Amsterdam: Elsevier.Google Scholar
  94. McDowall, D. G., Barker, J., and Jennett, W. B., 1966: Cerebrospinal fluid pressure measurements during anaesthesia. Anaesthesia 21, 189–201.PubMedCrossRefGoogle Scholar
  95. Wüllenweber, R., 1972: Comments to session 9. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 326–327. Berlin-Heidelberg-New York: Springer.Google Scholar
  96. Marshall, W. J. S., Jackson, J. L. F., and Langfitt, T. W., 1969: Brain swelling caused by trauma and arterial hypertension. Arch. Neurol. (Chic.) 21, 545–553.Google Scholar
  97. Martins, A. N., Wiley, J. K., and Myers, P. W., 1972: Dynamics of the cerebrospinal fluid and the spinal dura mater. J. Neurol. Neurosurg. Psychiat. 35, 468–473.PubMedCrossRefGoogle Scholar
  98. Marx, G. F., Andrews, C., and Orkin, L. R., 1962: Cerebrospinal fluid pressure during halothane anaesthesia. Canad. Anaesth. Soc. J. 9, 239–245.PubMedCrossRefGoogle Scholar
  99. Mason, M.S., and Raaf, J., 1961: Physiological alterations and clinical effects of urea-induced diuresis. J. Neurosurg. 18, 645–653.PubMedCrossRefGoogle Scholar
  100. Maxwell, R. E., Long, D. M., and French, L. A., 1972: The clinical effects of a synthetic gluco-corticoid used for brain edema in the practice of neurosurgery. In: Steroids and brain edema, H. J. Reulen and K. Schürmann (Eds.), pp. 219–232. Berlin- Heidelberg-New York: Springer.Google Scholar
  101. Meyer, J. S., and Hunter, J., 1957: Effects of hypothermia on local blood flow and metabolism during cerebral ischemia and hypoxia. J. Neurosurg. 14, 210–227.PubMedCrossRefGoogle Scholar
  102. Miller, J. D., Ledingham, I. McA., and Jennett, W. B., 1970: Effects of hyperbaric oxygen on intracranial pressure and cerebral blood flow in experimental cerebral oedema. J. Neurol. Neurosurg. Psychiat. 33, 745–755.PubMedCrossRefGoogle Scholar
  103. Ledingham, I. McA., 1971: Reduction of increased intracranial pressure. Comparison between hyperbaric oxygen and hyperventilation. Arch. Neurol. (Chic.) 24, 210–216.Google Scholar
  104. Garibi, J., 1972: Intracranial volume/pressure relationships during continuous monitoring of ventricular fluid pressure. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 270–274. Berlin-Heidelberg-New York: Springer.Google Scholar
  105. Nielsen, K. C., Nordström, L., and Silfvenius, H., 1962: Hypothermia with air cooling in neurosurgical operations under ether anaesthesia. Acta anaesth. scand. Suppl. 12, 53–54.Google Scholar
  106. Noell, W., und Schneider, M., 1944: Über die Durchblutung und die Sauerstoffversorgung des Gehirns. IV. Die Rolle der Kohlensäure. Pflügers Arch. 247, 514–527.CrossRefGoogle Scholar
  107. Noell, W., und Schneider, M., 1948: Zur Hämodynamik der Gehirndurchblutung bei Liquordrucksteigerung. Arch. Psychiat. Nervenkr. 118–180, 713–730.CrossRefGoogle Scholar
  108. Nornes, H., 1973a: Pressure transducer with disposable measuring head for ventricular fluid pressure monitoring. Acta neurol. scand. 49, 252–265.Google Scholar
  109. Nornes, H., 1973b: The role of intracranial pressure in the arrest of hemorrhage in patients with ruptured intracranial aneurysm. J. Neurosurg. 39, 226–234.PubMedCrossRefGoogle Scholar
  110. Magnaes, B., 1971: Supratentorial epidural pressure recorded during posterior fossa surgery. J. Neurosurg. 35, 541–549.PubMedCrossRefGoogle Scholar
  111. North, J. B., and Jennett, S., 1972: Impedance pneumography for the detection of abnormal breathing patterns associated with brain damage. Lancet 2, 212–213.PubMedCrossRefGoogle Scholar
  112. Olivecrona, H., 1940: Chirurgische Behandlung der Geschwülste. In: Die Spezielle Chirurgie der Gehirnkrankheiten, Vol. 3, F. Krause (Ed.), pp. 193–265. Stuttgart: F. Enke.Google Scholar
  113. Pappius, H. M., and Dayes, L. A., 1965: Hypertonie urea. Arch. Neurol. (Chic.) 13, 395–402.Google Scholar
  114. Paul, R. L., Polanco, O., Turney, S. Z., McAslan, T. C., and Cowley, A., 1972: Intracranial pressure response to alterations in arterial carbon dioxide pressure in patients with head injuries. J. Neurosurg. 36, 714–720.PubMedCrossRefGoogle Scholar
  115. Plum, F., and Posner, J. B., 1972: The diagnosis of stupor and coma. Second edition. Philadelphia: F. A. Davis Company.Google Scholar
  116. Pontén, IL, Kjällquist, Å., Lundberg, N., and Nilsson, L., 1968: Monitoring of the cerebral “perfusion pressure” in patients with intracranial hypertension. A preliminary report. Proceedings of Scand. Neurosurg. Soc. 20th Ann. Meeting, Uppsala, 1967. Acta neurol. scand. 44, 251.Google Scholar
  117. Kågström, E., and Sundbärg, G., 1973: Ventricular fluid drainage after subarachnoid hemorrhage. In: 5th international congress of neurological surgery, Congress series, No. 293. R. Carrea, S. Ishii, and D. Le Vay (Eds.), p. 49. Amsterdam: Exerpta Medica.Google Scholar
  118. Pool, J. H., and Potts, D. Y., 1965: Aneurysms and arteriovenous anomalies of the brain. Diagnosis and treatment, p. 201. New York: Harper and Row.Google Scholar
  119. Poppen, J. L., 1943: Ventricular drainage as a valuable procedure in neurosurgery. Arch. Neurol. Psychiat. (Chic.) 50, 587–589.Google Scholar
  120. Prados, M., Strowger, B., and Feindel, W., 1945: Studies on cerebral edema. Arch. Neurol. Psychiat. (Chic.) 54, 290–300.Google Scholar
  121. Ransohoff, J., 1972: The effects of steroids on brain edema in man. In: Steroids and brain edema, H. J. Reulen and K. Schürmann (Eds.), pp. 211–217. Berlin- Heidelberg-New York: Springer.Google Scholar
  122. Reed, D. J., and Woodbury, D. M., 1962a: Effect of hypertonic urea on cerebrospinal fluid pressure and brain volume. J. Physiol. (Lond.) 164, 252–264.Google Scholar
  123. Reed, D. J., and Woodbury, D. M.,1962b: Effect of urea and acetazolamide on brain volume and cerebrospinal fluid pressure. J. Physiol. (Lond.) 164, 265–273.Google Scholar
  124. Reivich, M., Dickson, J., Clark, J., Hedden, M., and Lambertsen, C. J., 1968: Role of hypoxia in cerebral circulatory and metabolic changes during hypocarbia in man: studies in hyperbaric milieu. Scand. J. clin. Lab. Invest. Suppl. 102, IV: B.Google Scholar
  125. Reulen, H. J., and Schürmann, K., 1972: Steroids and brain edema. Berlin-Heidelberg- New York: Springer.Google Scholar
  126. Risberg, J., Lundberg, N., and Ingvar, D. H., 1969: Regional cerebral blood volume during acute transient rises of the intracranial pressure (plateau waves). J. Neurosurg. 31, 303–310.PubMedCrossRefGoogle Scholar
  127. Rosomoff, H. L., 1959: Experimental brain injury during hypothermia. J. Neurosurg. 16, 177–187.PubMedCrossRefGoogle Scholar
  128. Rosomoff, H. L., 1962: Distribution of intracranial contents after hypertonic urea. J. Neurosurg. 19, 859–864.PubMedCrossRefGoogle Scholar
  129. Holaday, D. A., 1954: Cerebral blood flow and cerebral oxygen consumption during hypothermia. Amer. J. Physiol. 179, 85–88.PubMedGoogle Scholar
  130. Clasen, R. A., Hartstock, R., and Bebin, J., 1965: Brain reaction to experimental injury after hypothermia. Arch. Neurol. (Chic.) 13, 337–345.Google Scholar
  131. Rossanda, M., 1968: Prolonged hyperventilation in treatment of unconscious patients with severe brain injuries. Scand. J. clin. Lab. Invest. Suppl. 102, XIII: E.Google Scholar
  132. di Giugno, G., Corona, S., Bettinazzi, N., and Mangione, G., 1966: Oxygen supply to the brain and respirator treatment in severe comatose states. Acta anaesth. scand. Suppl. 23, 766.Google Scholar
  133. Rowan, J. O., Johnston, I. H., Harper, A. M., and Jennett, W. B., 1972: Perfusion pressure in intracranial hypertension. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 165–170. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  134. Roy, C. S., and Sherrington, C. S., 1890: On the regulation of the blood-supply of the brain. J. Physiol. 11, 85–108.PubMedGoogle Scholar
  135. Ryder, H. W., Espey, F. F., Kimbell, F. D., Penka, E. J., Rosenauer, A., Podolsky, B., and Evans, J. P., 1952: Influence of changes in cerebral blood flow on the cerebrospinal fluid pressure. Arch. Neurol. Psychiat. 68, 165–169.Google Scholar
  136. Ryder, H. W., Espey, F. F., Kimbell, F. D., Penka, E. J., Rosenauer, A., Podolsky, B., and Evans, J. P., 1953: The mechanism of the change in cerebrospinal fluid pressure following an induced change in the volume of the fluid space. J. Lab. clin. Med. 41, 428–435.PubMedGoogle Scholar
  137. Schettini, A., Cook, A. W., and Owre, E. S., 1967: Hyperventilation in craniotomy for brain tumour. Anesthesiology 28, 363–371.PubMedCrossRefGoogle Scholar
  138. Schoolar, J. C., Barlow, C. F., and Roth, L. J., 1960: The penetration of carbon-14 urea into cerebrospinal fluid and various areas of the cat brain. J. Neuropath, exp. Neurol. 19, 216–227.CrossRefGoogle Scholar
  139. Schutta, H. S., Kassell, N. F., and Langfitt, T. W., 1968: Brain swelling produced by injury and aggravated by arterial hypertension. A light and electron microscopic study. Brain 91, 281–294.PubMedCrossRefGoogle Scholar
  140. Sedzimir, C. R., 1959: Therapeutic hypothermia in cases of head injury. J. Neuro- surg. 16, 407–414.Google Scholar
  141. Shapiro, H. M., Wyte, S. R., Harris, A. B., and Galindo, A., 1972: Disposable system for intraventricular pressure measurement and CSF drainage. Technical note. J. Neurosurg. 36, 798–801.PubMedCrossRefGoogle Scholar
  142. Loeser, J., 1974: Barbiturateaugmented hypothermia for reduction of persistent intracranial hypertension. J. Neurosurg. 40, 90–100.PubMedCrossRefGoogle Scholar
  143. Shenkin, H. A., Goluboff, B., and Haft, H., 1962: The use of mannitol for the reduction of intracranial pressure in intracranial surgery. J. Neurosurg. 19, 897–901.PubMedCrossRefGoogle Scholar
  144. Shulman, K., and Rosomoff, H. L., 1959: Effect of hypothermia on mortality in experimental injury to the brain. Amer. J. Surg. 98, 704–705.PubMedCrossRefGoogle Scholar
  145. Sisson, W. B., and Oldendorf, W. H., 1971: Brain distribution spaces of mannitol-3H, inulin-14C, dextran-14C in the rat. Amer. J. Physiol. 221, 214–217.PubMedGoogle Scholar
  146. Smyth, G. E., and Henderson, W. R., 1938: Observations on the cerebrospinal fluid pressure on simultaneous ventricular and lumbar punctures. J. Neurol. Psychiat. 1, 226–237.CrossRefGoogle Scholar
  147. Sondergaard, W., 1961: Intracranial pressure during general anaesthesia. Dan. med. Bull. 8, 18.Google Scholar
  148. Strang, F. A., 1971: Relationship of central respiratory disturbances to sleep and disorders of consciousness. Proc. roy. Soc. Med. 64, 484–489.Google Scholar
  149. Sundbärg, G., Kjällquist, Ä., Lundberg, N., and Ponten, U., 1972: Complications due to prolonged ventricular fluid pressure recording in clinical practice. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 348–352. Berlin- Heidelberg-New York: Springer.Google Scholar
  150. Symon, L., Dorsch, N. W. C., and Stephens, R. J., 1972: Long term measurement of extradural pressure in “low pressure” hydrocephalus. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 280–285. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  151. Tindali, G. T., McGraw, C. P., Vanderveer, R. W., and Iwata, K., 1972: Cardiorespiratory changes associated with plateau waves in patients with head injury. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 227–231. Berlin-Heidelberg-New York: Springer.CrossRefGoogle Scholar
  152. Tolksdorf, S., 1959: Laboratory evaluation of anti-inflammatory steroids. Ann. N.Y. Acad. Sei. 82, 829–835.CrossRefGoogle Scholar
  153. Tourtellotte, W. W., Reinglass, J. L., and Newkirk, T. A., 1972: Cerebral dehydration action of glycerol. I. Historical aspects with emphasis on the toxicity and intravenous administration. Clin. Pharmacol. Ther. 13, 159–171.Google Scholar
  154. Troupp, H., 1967: Intraventricular pressure in patients with severe brain injuries. J. Trauma 7, 875–883.PubMedCrossRefGoogle Scholar
  155. Kuurne, T., Kaste, M., Yapalahti, M., and Yaltonen, S., 1972: Intraventricular pressure after severe brain injuries: prognostic value and correlation with blood pressure and jugular venous oxygen tension. In: Intracranial Pressure, M. Brock and H. Dietz (Eds.), pp. 222–226. Berlin-Heidelberg-New York: Springer.Google Scholar
  156. Yirno, M., Chiavarelli, S., et Cantore, G. P., 1961: Azione del glicerolo sull’edema cerebrale nel coniglio dopo eraniectomia. Gazz. int. Med. Chir. 66, 3509–3515.Google Scholar
  157. Weed, L. H., 1914: The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J. med. Res. 31, 51–91.PubMedGoogle Scholar
  158. Weed, L. H., 1935: Certain anatomical and physiological aspects of the meninges and cerebrospinal fluid. Brain 58, 383–397.CrossRefGoogle Scholar
  159. McKibben, P. S., 1919: Pressure changes in cerebrospinal fluid following intravenous injection of solutions of various concentrations. Amer. J. Physiol. 48, 512–530.Google Scholar
  160. Welch, K., and Friedman, V., 1960: The cerebrospinal fluid valves. Brain 83, 454.PubMedCrossRefGoogle Scholar
  161. White, R. J., Dakters, J. G., Yashon, D., and Albin, M. S., 1969: Temporary control of cerebrospinal fluid volume and pressure by means of an externalized valve- drainage system. J. Neurosurg. 30, 264–269.PubMedCrossRefGoogle Scholar
  162. Wise, B. L., and Chater, N., 1961: Effect of mannitol on cerebrospinal fluid pressure. Arch. Neurol. (Chic.) 4, 96–98.Google Scholar
  163. Wise, B. L., and Chater, N., 1962: The value of hypertonic mannitol solution in decreasing brain mass and lowering cerebrospinal fluid pressure. J. Neurosurg. 19, 1038–1043.PubMedCrossRefGoogle Scholar
  164. Wolff, H. G., and Forbes, H. S., 1929: The cerebral circulation. Observations of the pial circulation during changes in intracranial pressure. In: The intracranial pressure in health and disease, J. Browder, A. M. Rabiner, and F. A. Mettler (Eds.), pp. 91–103. Baltimore: Williams and Wilkins Company.Google Scholar
  165. Wright, R. D., 1938: Experimental observations on increased intracranial pressure. Aust. N. Z. J. Surg. 7–8, 215–235.CrossRefGoogle Scholar
  166. Wyler, A. R., and Kelly, W. A., 1972: Use of antibiotics with external ventriculostomies. J. Neurosurg. 37, 185–187.PubMedCrossRefGoogle Scholar
  167. Zwetnow, N. N., 1968: CBF autoregulation to blood pressure and intracranial pressure variations. Scand. J. clin. Lab. Invest. Suppl. 102, V: A.Google Scholar
  168. Zwetnow, N. N., 1970: Effects of increased cerebrospinal fluid pressure on the blood flow and on the energy metabolism of the brain. Thesis. Acta physiol. scand. Suppl. 339. Lund: StudentlitteraturGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1974

Authors and Affiliations

  • N. Lundberg
    • 1
  • Å. Kjällquist
    • 1
  • G. Kullberg
    • 1
  • U. Pontén
    • 1
  • G. Sundbärg
    • 1
  1. 1.Department of NeurosurgeryUniversity HospitalLundSweden

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