Abstract
The mechanisms of corrin and of coenzyme B12 dependent enzymatic reactions are complex and have been the subject of intense experimental effort, discussion and controversy. The difficulties preventing the understanding of the enzymatic function of corrinoid coenzymes were initially caused by the lack of information on the inorganic and organometallic reactions of cobalt in tetradentate, strong-field complexes. Since the discovery and study of vitamin B12 model compounds a wealth of experimental and theoretical data on the chemistry of cobalt in complexes related to vitamin B12 became available, which is now recognized to be relevant to the chemistry of vitamin B12 itself. Indeed, most of the known reactions of vitamin B12 have been duplicated with simpler model complexes, and vice versa. The detailed investigation of the nonenzymatic reactions of vitamin B12 and of vitamin B12 model compounds subsequently led to the formulation of mechanisms of some of the known corrin dependent enzymatic reactions and to a number of surprising qualitative and quantitative experimental correlations between nonenzymatic and enzymatic data.
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References
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Schrauzer, G. N., J. A. Seck, and T. M. Beckham: Reductive Co-C bond cleavage of alkylcorrins and of vitamin B12 model compounds by alkaline CO, S2O —4 and stannite. Bioinorganic Chemistry 2, 211 (1973).
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Schrauzer, G. N., and E. M. Rubin: Formation of Methylcobalamin from dimethylmercury and vitamin B12s. Unpublished results, 1972.
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Schrauzer, G.N. (1974). Mechanisms of Corrin Dependent Enzymatic Reactions. In: Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 31. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7094-6_10
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