Structural Investigations of Natural Products by Newer Methods of NMR Spectroscopy

  • R. J. Highet
  • E. A. Sokoloski
Part of the Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products book series (FORTCHEMIE (closed), volume 32)


When the use of nuclear magnetic resonance spectroscopy in natural product studies was reviewed in an earlier volume of this series (1), the technique was already established as a primary tool of structural investigation. Straight-forward nmr techniques suitable for simple analytical instruments and mass spectroscopy remain the natural product chemist’s first tools in the examination of natural materials. Often these methods together suffice either to demonstrate the structure of a compound, or to indicate the need for prompt recourse to the most definitive tool of structural investigation, x-ray crystallography. In recent years, methods have been developed to extend nmr methods to samples not previously amenable to this technique and to extract further structural information from the spectrum.


Nuclear Magnetic Resonance Chemical Shift Natural Product Structural Investigation Phosphonic Acid 
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© Springer-Verlag/Wien 1975

Authors and Affiliations

  • R. J. Highet
    • 1
  • E. A. Sokoloski
    • 1
  1. 1.Department of Health, Education, and Welfare, Public Health ServiceNational Institutes of Health, National Heart and Lung InstituteBethesdaUSA

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