Advertisement

Intrathecal Injection of a Neurolytic Solution for the Relief of Intractable Pain

  • J. Rétif
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 4)

Abstract

The concept according to which the different nerve fibers (myelinated and unmyelinated fibers of various diameters) can be affected differently by various blocking or destructive agents has been the rationale for many attempts to relieve pain or spasticity.

Keywords

Nerve Root Fine Fiber Intrathecal Injection Intractable Pain Phenol Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abbott, W. D., 1936: Intraspinal injection of absolute alcohol for intractable pain. Amer. J. Surg. 31, 351–353.CrossRefGoogle Scholar
  2. Adson, A. W., 1937: The value of and indications for intraspinal injections of alcohol in the relief of pain. Minn. Med. 20, 135–140.Google Scholar
  3. Andre-Balisaux, G., Gonsette, R., 1963: Etude anatomo-pathologique des effets de la phénolisation au niveau des cônes terminaux et des racines de la queue de cheval. Acta neurol. belg. 63, 489–498.PubMedGoogle Scholar
  4. Ansbro, F. P., 1950: Intraspinal segmental alcohol block for relief of intractable pain. Amer. J. Surg. 79, 276–281.PubMedCrossRefGoogle Scholar
  5. Baxter, D. W., Schacherl, V., 1962: Experimental studies on the morphological changes produced by intrathecal phenol. Caned. Med. Ass. J. 86/26, 1200–1205.Google Scholar
  6. Berry, K., Olszewski, J., 1963: Pathology of intrathecal phenol injection in man. Neurology 13, 152–154.Google Scholar
  7. Bonica, J. J., 1954: The management of pain. Philadelphia: Lea Febiger.Google Scholar
  8. Bradford, F. K., 1959: The use of a caudal air bubble in the control of alcohol injection to relieve flexion reflexes. J. Neurosurg. 16, 468–470.PubMedCrossRefGoogle Scholar
  9. Brihaye, J., Retif, J., Gregoire, A., 1961: L’injection sous-arachnoïdienne d’alcool dans le traitement de la douleur. Communication au Congrès International d’Anesthésiologie. Namur.Google Scholar
  10. Brihaye, J., Retif, J., Gregoire, A., 1962: Le traitement chirurgical de la douleur. Acta chir. belg., suppl. II–253–476, pp. 296–307.Google Scholar
  11. Brown, A. S., 1958: Treatment of intractable pain by subarachnoid injection of carbolic acid. Lancet 2, 975–978.PubMedCrossRefGoogle Scholar
  12. Coggeshall, R. E., Applebaum, M. L., Fazen, M., Stubbs, T. B., Sykes, M. T., 1975: Unmyelinated axons in human ventral roots, a possible explanation for the failure of dorsal rhizotomy to relieve pain. Brain 98, 157–166.PubMedCrossRefGoogle Scholar
  13. Cooper, I. S., Hirose, T., Matsuoka, S., Roth, D., Waltz, J. M., Ericsson, A. D., 1965: Specific neurotoxic perfusion: a new approach to selected cases of pain and spasticity. Neurology 15, 985–993.PubMedGoogle Scholar
  14. De Bisschop, G., Dumoulin, J., 1967: A propos du garrot ischémique. Electrodiagnostic 4, 75–81.Google Scholar
  15. De Jesus, P. V., Jr., Hausmanowa-Petrusewicz, I., Barchi, R. L., 1973: The effect of cold on nerve conduction of human slow and fast nerve fibers. Neurology 23, 1182–1189.PubMedGoogle Scholar
  16. Derrick, W. S., 1970: Control of pain in the cancer patient by subarachnoid alcohol block. Postgraduate Medicine 48, 232–237.PubMedGoogle Scholar
  17. Dogliotti, A. M., 1931: Traitement des syndromes douloureux de la périphérie par l’alcoolisation sous-arachnoïdienne des racines postérieures à leur émergence de la moelle épinière. Presse Méd. 39, 1249–1252.Google Scholar
  18. Dogliotti, A. M., 1943: Indikationen und Resultate der subarachnoïdalen Alkoholisation der Rückenmarkswurzeln. Wien. Med. Wschr. 18–19, 295–298.Google Scholar
  19. Dogliotti, A. M., 1957: Méthodes chirurgicales périphériques pour le traitement de la douleur chez les cancéreux. Rapports du XVIIe Congrès Soc. Int. Chir. Mexico.Google Scholar
  20. Dunphy, J. E., Alt, R. E., 1936: The. relief of pain by the subarachnoid injection of alcohol. The New England J. Med. 214, 472–477.Google Scholar
  21. Evans, R. J., Mackay, I. M., 1972: Subarachnoid phenol nerve blocks for relief of pain in advanced malignancy. Canad. J. Surg. 15, 50–53.PubMedGoogle Scholar
  22. Flanigan, S., Boop, W. C., 1974: Spinal intrathecal injection procedures in the management of pain. Clin. Neurosurg. 21, 229–238.PubMedGoogle Scholar
  23. Gallager, H. S., Yonezawa, T., Hay, R. C., Derrick, W., 1961: Subarachnoid alcohol block. II. Histologic changes in the central nervous system. Amer. J. Path. 38, 679–693.PubMedGoogle Scholar
  24. Gasser, H. S., Erlanger, J., 1929: The role of fiber size in the establishment of a nerve block by pressure of cocaine. Amer. J. Physiol. 88, 581–591.Google Scholar
  25. Gillman, J., 1972: Pain relief and other effects following barbotage. Lancet 1, 746.CrossRefGoogle Scholar
  26. Goff, C. W., 1936: Sciatic neuralgia controlled by intraspinal (subarachnoid) injections of ethyl alcohol. Amer. J. Surg. 32, 37.CrossRefGoogle Scholar
  27. Groff, R. A., 1939: Alcoholic injections for the relief of intractable pain. Surg. Clin. N. Amer. 19, 1569–1581.Google Scholar
  28. Lewy, F. H., 1941: Dangers of subarachnoid injection of alcohol for relief of pain. Arch. Neurol. Psych. 45, 533–535.Google Scholar
  29. Grant, F. C., 1941: Surgical methods for the relief of pain. J. A. M. A. 116, 567–571.Google Scholar
  30. Greenhill, J. P., Schmitz, H. E., 1935: Intraspinal (subarachnoid) injection of alcohol for pain associated with malignant conditions of the female genitalia. J. A. M. A. 105, 406–409.Google Scholar
  31. Guttman, S. A., Pardee, I., 1944: Spinal cord level syndrome following intrathecal ammonium sulfate and procaine hydrochloride. A case report with autopsy findings. Anesthesiology 5, 347–353.CrossRefGoogle Scholar
  32. Hand, L. V., 1944: Subarachnoid ammonium sulfate therapy for intractable pain. Anesthesiology 5, 354–358.CrossRefGoogle Scholar
  33. Hansebout, R. R., Cosgrove, J. B. R., 1966: Effects of intrathecal phenol in man. Neurology 16, 277–282.PubMedGoogle Scholar
  34. Hariga, J., 1966: Influences sur la motricité de la suppression des effeßteurs gamma par alcoolisation des nerfs périphériques. Etude expérimentale chez le chat décérébré. Résultats thérapeutiques dans l’infirmité motrice cérébrale. Acta Neurol. Psych. Belg. 66, 607–711.Google Scholar
  35. Hariga, J., Tardieu, G., Tardieu, C., Gagnard, L., 1966: Effets de l’application d’alcool dilué sur le nerf. Partie 1: confrontation de l’étude dynamographique et de l’étude histologique chez le chat décérébré. J. Neurol. Sei. 3, 284–299.CrossRefGoogle Scholar
  36. Hay, R. C., Yonezawa, T., Derrick, W. S., 1959: Control of intractable pain in advanced cancer by subarachnoid alcohol block. J. A. M. A. 169, 1315–1320.Google Scholar
  37. Hitchcock, E., 1969: Osmolytic neurolysis for intractable facial pain. Lancet 1, 434–436.PubMedCrossRefGoogle Scholar
  38. Hughes, J. T., 1966: Pathological findings following the intrathecal injection of ethyl alcohol in man. Paraplegia 4, 167–175.CrossRefGoogle Scholar
  39. Hughes, J. T., 1970: Thrombosis of the posterior spinal arteries: a complication of an intrathecal injection of phenol. Neurology 20, 659–664.PubMedGoogle Scholar
  40. Iggo, A., Walsh, E. G., 1960: Selective block of small fibres in the spinal roots by phenol. Brain 83, 701–708.PubMedCrossRefGoogle Scholar
  41. Kennedy, W. F., Akamatsu, T., 1963: Subarachnoid block with phenol-glycerine for the relief of intractable pain. Anesthesiology 24, 584–585.CrossRefGoogle Scholar
  42. Knott, L. W., Katz, J., Rubinstein, L. J., 1969: Separate and combined effects of phenol, hyaluronidase and dimethyl sulfoxide on the sciatic nerve of the rat. II. Chronic studies. Neurology 19, 946–953.PubMedGoogle Scholar
  43. Kuzucu, E. Y., Derrick, W. S., Wilber, S. A., 1966: Control of intractable pain with subarachnoid alcohol block. J. A. M. A. 195, 541–544.PubMedCrossRefGoogle Scholar
  44. Lourie, H., Vanasupa, P., 1963: Comments on the use of intraspinal phenolpantopaque for relief of pain and spasticity. J. Neurosurg. 20, 60–63.PubMedCrossRefGoogle Scholar
  45. Lucas, J. T., Ducker, T. B., Perot, P. L., Jr., 1975: Adverse reactions to intrathecal saline injection for control of pain. J. Neurosurg. 42, 557–561.PubMedCrossRefGoogle Scholar
  46. Maher, R. M., 1955. Relief of pain in incurable cancer. Lancet 1, 18–20.CrossRefGoogle Scholar
  47. Maher, R. M., 1957: Neurone selection in relief of pain. Further experiences with intrathecal injections. The Lancet 1, 16–19.CrossRefGoogle Scholar
  48. Maher, R. M., 1960: Further experiences with intrathecal and subdural phenol. Observations on two forms of pain. The Lancet, 895–899.Google Scholar
  49. Maher, R. M., 1963: Intrathecal chlorocresol in the treatment of pain in cancer. The Lancet 1, 965–967.CrossRefGoogle Scholar
  50. Mark, V. H., White, J. C., Zervas, N. T., Ervin, F. R., Richardson, E. P., 1963: Intrathecal use of phenol for the relief of chronic severe pain. New Engl. J. Med. 267, 589–593.Google Scholar
  51. Nathan, P. W., 1959: Intrathecal phenol to relieve spasticity in paraplegia. The Lancet II, 1099–1102.CrossRefGoogle Scholar
  52. Nathan, P. W., Scott, T. G., 1958: Intrathecal phenol for intractable pain: safety and dangers of method. Lancet 1, 76–80.PubMedCrossRefGoogle Scholar
  53. Nathan, P. W., Sears, T. A., 1960: Effects of phenol on nervous conduction. J. Physiol. 150, 565–580.PubMedGoogle Scholar
  54. Nathan, P. W., Sears, T. A., Smith, M.C., 1965: Effects of phenol solutions on the nerve roots of the cat: an electrophysiological and histological study. J. Neurol. Sei. 2, 7–29.CrossRefGoogle Scholar
  55. Olmsted, J. M. D., Hodgson, P., 1931: An explanation of the results of the “alcohol block”. Amer. J. Physiol. 97, 597–601.Google Scholar
  56. Ottley, C., 1938: Intrathecal alcohol injection for relief of pain: a review. Brit. Med. J. 510–512.Google Scholar
  57. Papo, I., Visca, A., Caruselli, G., 1968: Indications et limites de la radicotomie chimique par le phénol sous-arachnoïdien dans le traitement des algies cancéreuses. Neurochirurgie 14, 617–626.PubMedGoogle Scholar
  58. Papo, I., Pellegrini, G., Scarlato, G., 1967: La radicotomie chimique par substances phénoliques. Acta Neurol. Psychiat. Belg. 67, 125–132.Google Scholar
  59. Papo, I., Visca, A., 1973: Intrathecal phenol in the treatment of cancer pain. J. Neurosurg. Sei. 17, 146–156.Google Scholar
  60. Pedersen, E., Reske-Nielsen, E., 1965: Neuropathology of subarachnoid phenol-glycerin. Acta Neuropathol. 5, 112–116.PubMedCrossRefGoogle Scholar
  61. Peyton, W. T., Semansky, E. J., Baker, A. B., 1937: Subarachnoid injection of alcohol for relief of intractable pain with discussion of cord changes found at autopsy. Amer. J. Cancer 30, 709–717.Google Scholar
  62. Pitts, W., Browder, J., 1939: Spinal subarachnoid injection of absolute alcohol for the relief of intractable pain. Ann. Surg. 109, 33–42.PubMedCrossRefGoogle Scholar
  63. Poppen, J. L., 1936: The relief of pain by the use of subarachnoid alcohol injection. Indications, contra-indications, technics and results in 82 patients. Surg. Clin. N. Amer. 16, 1663–1668.Google Scholar
  64. Rasminsky, M., 1973: The effects of temperature on conduction in demyelinated single nerve fibers. Arch. Neural. 28, 287–292.Google Scholar
  65. Russell, W. R., 1936: Intraspinal injection of alcohol for intractable pain. Lancet 1, 595–599.CrossRefGoogle Scholar
  66. Saltzstein, H. C., 1934: Intraspinal (subarachnoid) injection of absolute alcohol: for the control of pain in far advanced malignant growths. J. A. M. A. 103, 242–243.Google Scholar
  67. Savitz, M. H., Malis, L. I., 1973: Intractable pain treated with intrathecal isotonic iced saline. J. Neurol. Neurosurg. Psychiat. 36, 417–420.PubMedCrossRefGoogle Scholar
  68. Schaumburg, H., Byck, R., Herman, R., Rosengart, C., 1967: Peripheral nerve damage by cold. Arch. Neurol. 16, 103–109.PubMedGoogle Scholar
  69. Schaumburg, H. H., Byck, R., Weller, R. O., 1970: The effect of phenol on peripheral nerve; an histological and electrophysiological study. J. Neuropath. Exp. Neurol. 29, 615–630.PubMedCrossRefGoogle Scholar
  70. Sindou, M., Fischer, G., Goutelle, A., Mansuy, L., 1974: La radicellotomie postérieure sélective. Premiers résultats dans la chirurgie de la douleur. Neurochirurgie 20, 391–408.PubMedGoogle Scholar
  71. Sloane, P., 1935: Syndrome referable to the cauda equina following the intraspinal injection of alcohol for relief from pain. Arch. Neurol. Psych. 34, 1120–1123.Google Scholar
  72. Smith, M. C., 1964: Histological findings following intrathecal injections of phenol solutions for relief of pain. Brit. J. Anaesth. 36, 387–406.PubMedCrossRefGoogle Scholar
  73. Stern, E. L., 1934: Relief of intractable pain by the intraspinal (subarachnoid) injection of alcohol. Amer. J. Surg. 25, 211–227.CrossRefGoogle Scholar
  74. Stern, E. L., 1936: The intraspinal injection of alcohol for the relief of pain and for sympathetic nervous system disorders. Med. Rec. 143, 327–331.Google Scholar
  75. Stewart, W. A., Lourie, H., 1963: An experimental evaluation of the effects of sub-arachnoid injection of phenol pantopaque in Cats. J. Neurosurg. 20, 64–72.PubMedCrossRefGoogle Scholar
  76. Stovner, J., Endresen, R., 1972: Intrathecal phenol for cancer pain. Acta anaesth. Scand. 16, 17–21.Google Scholar
  77. Superville-Sovak, B., Rasminsky, M., Finlayson, M. H., 1975: Complications of phenol neurolysis. Arch. Neurol. 32, 226–228.PubMedGoogle Scholar
  78. Tank, T. M., Dohn, D. F., Gardner, W. J., 1963: Intrathecal injections of alcohol or phenol for relief of intractable pain. Cleveland Clin. Quart. 30, 111–117.Google Scholar
  79. Tardieu, G., Hariga, J., Tardieu, C., Gagnard, L., Velin, J., 1964: Traitement de la spasticité par infiltration d’alcool dilué au point moteur ou par injection épidurale. Rev. Neurol. 110, 563–565.Google Scholar
  80. Tardieu, G., Tardieu, C., Hariga, J., 1971: Infiltrations par alcool à 45° des points moteurs, des racines par voie épidurale, ou du nerf postérieur. Leurs indications et contre-indications dans les divers modes de „spasticité“ (expérience de 10 ans). Rev. Neurol. 125, 63–69.PubMedGoogle Scholar
  81. Todd, T. F., 1939: Relief of intractable pain in carcinoma of the cervix uteri. Lancet 2, 1305–1308.CrossRefGoogle Scholar
  82. Truelsen, F., 1943: Subarachnoid alcohol injection for the relief of intractable pain. Acta Chir. Scand. 88, 17–32.Google Scholar
  83. Uematsu, S., Udvarhelyi, G. B., Benson, D. W., Siebens, A. A., 1974: Percutaneous radiofrequency rhizotomy. Sur. Neurol. 2, 319–325.Google Scholar
  84. Vlahovitch, B., Fuentes, J. M., 1975: Résultats de la radicellotomie sélective postérieure à l’étage lombaire et cervical. Neurochirurgie 21, 29–42.PubMedGoogle Scholar
  85. White, J. C., Sweet, W. H., 1969: Pain and Neurosurgeon. Subarachnoid block with Phenol, pp. 160–167. Springfield, Ill.: Ch. C Thomas.Google Scholar
  86. White, J. C., 1965: Relief of pain in terminal cancer. Surg. Gyn. Obstet. 120, 115–116.Google Scholar
  87. Zuzucu, E. Y., Derrick, W. S., Wilber, S. A., 1966: Control of intractable pain with subarachnoid alcohol block. J. A. M. A. 195, 541–544.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1977

Authors and Affiliations

  • J. Rétif
    • 1
  1. 1.Department of NeurosurgeryUniversity of BrusselsBelgium

Personalised recommendations