Clinical Relevance of Cerebral Blood Flow Measurements

  • N. A. Lassen
  • D. H. Ingvar
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 4)


In 1945 Kety in collaboration with Schmidt developed the nitrous oxide method for measuring the average cerebral blood flow (CBF) and the average cerebral metabolic rate of oxygen (CMRO2) in man1. The method has given us a solid basis for understanding the overall blood flow and energy metabolism of the brain in health and disease2. Since then, several other methods have been devised including methods allowing measurement of flow in fairly small regions of the brain (rCBF) using radioisotopes. And now the cerebral circulation is probably better understood than that of any other organ of the body. It is then pertinent to ask, whether the rather massive clinical and experimental research on CBF has yielded a practical fall-out? This is the topic of the present paper.


Cerebral Blood Flow Internal Carotid Artery Regional Cerebral Blood Flow Occlude Internal Carotid Artery Epileptogenic Focus 
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Copyright information

© Springer-Verlag/Wien 1977

Authors and Affiliations

  • N. A. Lassen
    • 1
    • 2
  • D. H. Ingvar
    • 1
    • 2
  1. 1.Department of Clinical PhysiologyBispebjerg HospitalCopenhagenDenmark
  2. 2.Department of Clinical NeurophysiologyUniversity HospitalLundSweden

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