Chemotherapy of Brain Tumours

  • J. Hildebrand
  • J. Brihaye
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 5)


The choice of drugs in antineoplastic chemotherapy remains still largely empirical. A better understanding of some basic phenomena such as metabolism and kinetics of malignant cells is essential for a more rational choice and more efficient routes and schedules of anticancerous drug administration. Equally important, particularly for brain tumours, are pharmacological factors: the passage of drugs across the blood-brain barrier, their liposolubility, state of ionization, diffusion from cerebrospinal fluid (CSF) into the tumours, and their half-life in various compartments of the body.


Brain Tumour Malignant Glioma Glioblastoma Multiforme Malignant Brain Tumour Antineoplastic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 1978

Authors and Affiliations

  • J. Hildebrand
    • 1
  • J. Brihaye
    • 1
  1. 1.Departments of Internal Medicine and Neurosurgery, Institut BordetUniversity of BrusselsBelgium

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