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Chemotherapy of Brain Tumours

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Advances and Technical Standards in Neurosurgery

Part of the book series: Advances and Technical Standards in Neurosurgery ((NEUROSURGERY,volume 5))

Abstract

The choice of drugs in antineoplastic chemotherapy remains still largely empirical. A better understanding of some basic phenomena such as metabolism and kinetics of malignant cells is essential for a more rational choice and more efficient routes and schedules of anticancerous drug administration. Equally important, particularly for brain tumours, are pharmacological factors: the passage of drugs across the blood-brain barrier, their liposolubility, state of ionization, diffusion from cerebrospinal fluid (CSF) into the tumours, and their half-life in various compartments of the body.

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References

  • Ariel, I. M., 1961: Intra-arterial chemotherapy for metastatic cancer to the brain. Amer. J. Surg. 102, 647–650.

    Article  PubMed  CAS  Google Scholar 

  • Aronson, H. A., Flanigan, S., Mark, J. B. D., 1963: Chemotherapy of malignant brain tumors using regional perfusion. I. Technic and patient selection. Ann. Surg. 157, 394–399.

    Article  PubMed  CAS  Google Scholar 

  • Ausman, J. I., Shapiro, W. R., Rall, D. P., 1970: Studies on the chemotherapy of experimental brain tumors: Development G experimental model. Cancer Res. 30, 2394–2400.

    PubMed  CAS  Google Scholar 

  • Ausman, J. I., Levin, V. A., Brown, W. E., Rall, D. P., Fenstermacher, J. D., 1977: Brain-tumor chemotherapy. Pharmacological principles derived from a monkey brain-tumor model. J. Neurosurg. 46, 155–164.

    Article  PubMed  CAS  Google Scholar 

  • Band, P. R., Weir, B. K. A., Urtasun, R. C., Blain, G., McLeon, D., Wilson, F., Mielke, B., Grace, M., 1974: Radiotherapy and CCNU in grade III and IV astrocytoma. ASCO abstracts 25, 161.

    Google Scholar 

  • Barker, M., Hoshino, T., Gurcay, O., Wilson, C. B., Nielsen, S. L., Downie, R., Eliason, J., 1973: Development of an animal brain tumor. Model and its response to therapy with 1,3-BIS(2-Chloroethyl)-1-introsourea. Cancer Res. 33,976–986.

    PubMed  CAS  Google Scholar 

  • Bellman, S., Hugosson, R., Johansson, B., Sjögren, S. E., 1964: Chemotherapy of five supratentorial malignant gliomas with intra-arterial infusion of methotrexate. Acta Chir. Scand. 127,569–574.

    PubMed  CAS  Google Scholar 

  • Bleyer, W. A., Drake, J. C., Chabner, B. A., 1973: Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia. IV. Engl. J. Med. 289, 770–773.

    CAS  Google Scholar 

  • Brihaye, J., Gueuning, Ch., Huysman, E., 1971: Les tumeurs cérébrales. In: chimiothérapie et chirurgie. Acta Chir. Belg., suppl. 1, 42–59.

    Google Scholar 

  • Brisman, R., Houseplan, E. M., Chang, C., Duffy, P., Balis, E., 1976: Adjuvant nitrosourea therapy for glioblastoma. Arch. Neurol. 33, 745–750.

    PubMed  CAS  Google Scholar 

  • Brouty-Boye, G., Constans, J. P., 1976: Action comparative in vitro de divers agents antimitotiques sur des lignées cellulaires établies à partir de tumeurs cérébrales humaines. Neurochirurgie 22,69–76.

    PubMed  CAS  Google Scholar 

  • Burgess, E. A., Sylven, D., 1962: Glucose, lactate and lactic dehydrogenase activity in normal interstitial fluid and that of mouse tumours. Cancer Res. 22,581–587.

    PubMed  CAS  Google Scholar 

  • Chassard, J. L., Dutou, L., Gerard, J. P., Papillon, J., 1975: La radiothérapie postopératoire des gliomes hémisphériques de l’adulte. A propos d’une statistique de 134 observations. Neurochirurgie 21,377–390.

    PubMed  CAS  Google Scholar 

  • Chen, T. T., Meahey, J., Jr., 1973: Effect of corticosteroid on protein and nucleic acid synthetics in human glial tumor cells. Cancer Res. 33, 1721–1723.

    PubMed  CAS  Google Scholar 

  • Cuatico, W., Cho, J. R., Spiegelman, S., 1973: Particles with RNA of high molecular weight and RNA-directed DNA polymerose in human brain tumors. Puec. Nat. Acad. Sci. 70,2789–2793.

    Article  CAS  Google Scholar 

  • Davis, P. L., Shumway, M. H., Siu, B., 1958: Triethylenethiophosphoramide in treatment of metastatic cerebral malignancy. JAMA 167, 726–727.

    CAS  Google Scholar 

  • Davis, P. L., Shumway, M. H., 1961: Thiotepa in treatment of metastatic cerebral malignancy. JAMA 175, 714–715.

    PubMed  CAS  Google Scholar 

  • Denlinger, R. H., Koestner, A., Swenberg, J. A., 1973: An experimental model for selective production of neoplasms of the peripheral nervous system. Acta Neuropathol. 23, 219–229.

    CAS  Google Scholar 

  • Eckman, W. W., Patlak, C. S., Fenstermacher, J. D., 1974: A critical evaluation of the principles governing the advantages of intra-arterial infusions. J. Pharmacokinet. Biopharm. 2, 257–285.

    Article  PubMed  CAS  Google Scholar 

  • Edland, R. W., Javid, M., Ansfield, F. J., 1971: Glioblastoma multiforme. An analysis of the results of post operative radiotherapy alone versus radiotherapy and concomitant s’fluorouracil. Amer. J. Roentg. 3, 337–342.

    Google Scholar 

  • Engelhardt, P., 1976: Intrathecal cystostatic therapy of meningeal carcinomatosis. Autoradiographie investigations of the CSF cells. J. Neurol. 213, 309–315.

    Article  PubMed  CAS  Google Scholar 

  • EORTC Brain Tumor Group, 1976: Effect of CCNU on survival, rate of objective remission and duration of free interval in patients in the malignant brain gliomafirst evaluation. Eur. J. Cancer 12,41–45.

    Article  Google Scholar 

  • Fewer, D., Wilson, C. B., Boldrey, E. B., Enot, J. K., 1972: Phase II study of CCNUNSC 79037 in the treatment of brain tumours. Cancer Chemother. Rep. 56, 421–427.

    CAS  Google Scholar 

  • Fewer, D., Powell, M. R., 1972: The chemotherapy of brain tumours. Clinical experience in the carmustine (BCNU) and vincristine. JAMA 222, 549–552.

    Article  PubMed  CAS  Google Scholar 

  • Frankel, S. A., German, W. J., 1958: Glioblastoma multiforme. Review of 219 cases with regard to natural history, pathology, diagnostic methods and treatment. J. Neurosurg. 15,489–503.

    Article  PubMed  CAS  Google Scholar 

  • French, J. D., West, P. M., Amerongen, F. K. von, Magoun, H. W., 1952: Effects of intracarotid administration of nitrogen mustard on normal brain and brain tumors. J. Neurosurg. 9, 378–389.

    Article  PubMed  CAS  Google Scholar 

  • Fumagalli, R., Grossi-Paoletti, E., Paoletti, P., Paoletti, R., 1964: Studies on lipids in brain donors. I occurence and signification of sterol precursors of cholesterol in human brain tumors. J. Neurosurg. 2, 561–565.

    Google Scholar 

  • Garfield, J., Dayan, A. D., 1973: Postoperative intracavity chemotherapy of malignant gliomas. A preliminary study using methotrexate. J. Neurosurg. 39, 315–322.

    Article  PubMed  CAS  Google Scholar 

  • Garfield, J., Dayan, A. D., Weller, R. O., 1975: Postoperative intracavity chemotherapy of malignant supratentorial astrocytomas using BCNU. Clinical Oncology 1, 213–222.

    PubMed  CAS  Google Scholar 

  • Geran, R. I., Congleton, G. F., Dudeck, L. E., Abbott, B. J. de, Gargus, J. L., 1974: A mouse ependymoblastoma as an experimental model for screening potential antimoplastic drugs. Cancer Chemother. Rep. 4, 53–87.

    CAS  Google Scholar 

  • Grasso, R. J., 1976: Transient inhibition of cell proliferation by glucocorticoids in rat glioma monolayer cultures. Abstracts Am. Ass. Cancer Res., p. 82.

    Google Scholar 

  • Greenhouse, A. H., Neubuerger, K. T., Bowerman, D. L., 1964: Brain damage after intracarotid infusion of methotrexate. Arch. Neurol. 11, 618–625.

    PubMed  CAS  Google Scholar 

  • Gurcay, O., Wilson, C. B., Barker, M., Eliason, J., 1971: Corticoid effects on transplantable rat glioma. Arch. Neurol. 24, 266–269.

    PubMed  CAS  Google Scholar 

  • Gutin, Ph., Weiss, H. D., Wiernik, P. H., Walker, M. D., 1976: Intrathecal N, N’, N“-Triethylenethiophosphamide [Thio-Tepa (NSC 6396)] in the treatment of malignant meningeal disease. Phase I-CII study. Cancer 38, 1471–1475.

    CAS  Google Scholar 

  • Hayakawa, T., Yamada, R., Kanai, N., Kuroda, R., Ushio, Y., Higashi, H., Mogami, H., 1970: Intrathecal chemotherapy. Selection of cytostatic agents. Brit. J. Cancer 24, 489–497.

    Article  CAS  Google Scholar 

  • Hayakawa, T., Ushio, Y., Morimoto, K., Hasegawa, H., Mogami, H., Horibata, K., 1976: Uptake of bleomycin by human brain tumours. J. Neurol. Neurosurg. Psych. 39, 341–349.

    Article  CAS  Google Scholar 

  • Heppner, F., Diemath, H. E., 1963: Lokale Chemotherapie der Hirntumoren. Acta Neurochir. (Wien) 11, 287–293.

    Article  CAS  Google Scholar 

  • Hildebrand, J., Levin, S., 1973: Enzymatic activities in cerebrospinal fluid in patients with neurological diseases. Acta Neurol. Belg. 73, 229–240.

    PubMed  CAS  Google Scholar 

  • Hildebrand, J., Brihaye, J., Wagenknecht, L., Michel, J., Kenis, Y., 1975: Combination therapy with CCNU, vincristine and methotrexate in primary and metastatic brain tumors. Eur. J. Cancer 11, 585–587.

    Article  PubMed  CAS  Google Scholar 

  • Hoshino, T., Barker, M., Wilson, C. B., Boldrey, E. B., Fewer, D., 1972: Cell kinetics of human gliomas. J. Neurosurg. 37, 15–26.

    Article  PubMed  CAS  Google Scholar 

  • Hoshino, T., Barker, M., Wilson, C. B., 1975: The kinetics of cultured human glioma cells. Acta Neuropathol. 32, 235–244.

    Article  PubMed  CAS  Google Scholar 

  • Hoshino, T., Wilson, C. B., Rosenblum, M. L., Barker, M., 1975: Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas. J. Neurosurg. 43, 127–135.

    Article  PubMed  CAS  Google Scholar 

  • Introzzi, G., Paoletti, P., Pezzotta, S., Robustelli della Cuna, G., Rodriguezy Baena, R., 1975: The use of BCNLT in chemotherapy of tumors of the central nervous system. J. Neurosurg. Sei. 19, 223–225.

    CAS  Google Scholar 

  • Jelsma, R., Bucy, P. C., 1967: The treatment of glioblastoma multiforme of the brain. J. Neurosurg. 27, 388–400.

    Article  PubMed  CAS  Google Scholar 

  • Jelsma, R., Bucy, P. C., 1969: Glioblastoma multiforme. Its treatment and some factors. Effecting survival. Arch. Neurol. 20, 161–171.

    PubMed  CAS  Google Scholar 

  • Kennedy, B. J., Brown, J. H., Yarbo, J. W., 1965: Mithramycin (NSC-24559) therapy for primary glioblastomas. Cancer Chemother. Rep. 48, 59–63.

    PubMed  CAS  Google Scholar 

  • Kennedy, B. J., Yarbo, J. W., Kickertz, V., Sandberg-Wollheim, M., 1968: Effects of mithramycin on a mouse glioma. Cancer Res. 28, 91–97.

    PubMed  CAS  Google Scholar 

  • Khanna, H. L., Bailey, I. C., Taylor, A. R., Grebbell, F. S., 1969: Epodyl in the management of cerebral glioma. Neurology 19, 570–573.

    PubMed  CAS  Google Scholar 

  • Koestner, A., Swenberg, J. A., Wechsler, W., 1972: Experimental tumors of the nervous system induced by resorptive N-nitrosourea compounds. In: Progress in Experimental Tumor Research 17, 9–30. Editor G. Bingham Basel: S. Karger.

    Google Scholar 

  • Kontras, S. B., Newton, W. A., Sayers, M. P., 1962: Preliminary report on the use of intrathecal methotrexate in brain tumors of childhood. Proc. Amer. Ass. Cancer Res. 3, 151.

    Google Scholar 

  • Koo, A. H., Fewer, D., Wilson, C. B., Newton, T. H., 1972: Lack of correlation between clinical and angiographie findings in patients with brain tumours under BCNU chemotherapy. J. Neurosurg. 37, 9–14.

    Article  PubMed  CAS  Google Scholar 

  • Kumar, A. R. V., Renaudin, J., Wilson, C. B., Boldrey, E. B., Enot, K. J., Levin, V. A., 1974: Procarbazine hydrochloride in the treatment of brain tumors. Phase 2 study. J. Neurosurg. 40,365–371.

    Article  Google Scholar 

  • Kun-Yu Wu, K., Jacobsen, C. D., Hoak, J. C., 1973: Plasminogen in normal and abnormal human cerebrospinal fluid. Arch. Neurol. 28, 64–66.

    Google Scholar 

  • Lassman, L. P., Pearce, G. W., Gang, J., 1965: Sensitivity of intracranial gliomas to vincristine sulphate. Lancet, no. 7380, 296–297.

    Article  Google Scholar 

  • Laurent, G., Atassi, G., Hildebrand, J., 1976: Potentiation of 1-(2-chloroethyl)3-cyclohexyl-1-nitrosourea (CCNU) by amphoterican B (AMB) in marine ependymoblastoma. Cancer Res. 36, 4069–4073.

    PubMed  CAS  Google Scholar 

  • Levin, V. A., Shapiro, W. R., Clancy, T. P., Oliverio, V. T., 1970: The uptake, distribution, and antitumor activity of 1-(2-chloroethyl)-3-cyclohexyl-3-nitrosourea in the murin glioma. Cancer Res. 30,2451–2455.

    PubMed  CAS  Google Scholar 

  • Levin, V. A., Kabra, P., 1975: Brain and tumor pharmacokinetics of BCNU and CCNU following I.V. and intracarotid artery (I.C.A.) administration. Proc. Amer. Ass. Cancer Res. 16,19.

    Google Scholar 

  • Levine, M. A., Walker, M. D., Weiss, H. D., 1974: Intravenous methyl-CCNU in the treatment of malignant glioma. ASCO Abstracts, p. 167.

    Google Scholar 

  • Long, J. M., 1970: Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J. Neurosurg. 32,127–144.

    Article  PubMed  CAS  Google Scholar 

  • Luyendijk, W., Beusekom, G. Th. van, 1966: Chemotherapy of cerebral gliomas with intracarotid methotrexate-infusion. Acta Neurochir. (Wien) 15,234–248.

    Article  CAS  Google Scholar 

  • Matricali, B., 1974: Chemotherapie van het maligne gliomaa cerebri. Nederland. Tijdschr. Geneesk. (in press).

    Google Scholar 

  • Maker, H. S., Lehrer, G. M., Silides, D. J., Weiss, C., 1969: Circulatory factors in the carbohydrate metabolism of an experimental glial neoplasm. Ann. N.Y. Acad. Sei. 195,461–471.

    Article  Google Scholar 

  • Marne, L., Nouet, J. P., Robert, J., Chai, N., Houdart, R., 1973: Use of radioactive bleomycin to detect malignant intracranial tumors. J. Neurosurg. 39,735–741.

    Article  Google Scholar 

  • Mark, V. H., Kjellberg, R. N., Ojemann, R. G., Soloway, A. H., 1960: Treatment of malignant brain tumors with alkylating agents. (Thiotepa triethylene thiophosphoramide): Its differential concentration and toxicity after arterial infusion. Neurology 10, 772–776.

    PubMed  CAS  Google Scholar 

  • Mathe, G., Kenis, Y., 1975: La chimiothérapie des cancers. Paris: Expansion scientifique française. 1975.

    Google Scholar 

  • Morton, L. J., Heby, O., Levin, V. A., Lubich, W. P., Crafts, D. C., Wilson, C. B., 1976: The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors. Cancer Res. 36, 973–977.

    Google Scholar 

  • Newton, K. A., 1962: Intermittent intra-arterial injection and continuous intravenous infusion in the treatment of advanced cancer. Proc. Roy. Soc. Med. 55, 646–649.

    PubMed  CAS  Google Scholar 

  • Newton, W. A., Jr., Sayers, H. P., 1965: Intrathecal methotrexate therapy of brain tumors of childhood. Proc. Amer. Ass. Cancer Res. 4,190.

    Google Scholar 

  • Newton, W. A., Sayers, M. P., Samuels, L. D., 1968: Intrathecal methotrexate therapy NSC-740 for brain tumors in children. Cancer Chemother. Rep. 52, 257–261.

    PubMed  Google Scholar 

  • Norrel, H., Wilson, C. B., 1967: Brain tumor chemotherapy with methotrexate given intrathecally. JAMA 201, 93–95.

    Article  Google Scholar 

  • Ommaya, A. K., Rubin, R. C., Henderson, E. S., Rall, D. P., Gieseke, F. G., Bering, E. A., Bagan, M., 1965: A new approach to the treatment of inoperable brain tumors. Med. Ann. DC. 34, 455–458.

    CAS  Google Scholar 

  • Perese, D. M., Day, C. E., Chardack, W. M., 1962: Chemotherapy of brain tumors by intra-arterial infusion. J. Neurosurg. 19, 215–219.

    Article  PubMed  CAS  Google Scholar 

  • Pons, A., Armand, J. P., Combes, P. F., Nadal, P., 1975: Survie des malades atteints de tumeurs cérébrales sus-tentorielle primitives, en fonction des associations thérapeutiques. Neurochirurgie 21,408–410.

    PubMed  CAS  Google Scholar 

  • Price, L. A., Goldie, J. H., Hill, B. T., 1975: Methodichlorophen as anti-tumor drug. Brit. Med. J. 2, 20–21.

    Article  PubMed  CAS  Google Scholar 

  • Pouillart, P., Schwarzenberg, L., Ameil, J. L., Mathe, G., Huguenin, P., Morin, P., Baron, A., Laparre, Ch., Parrot, R., 1975: Combinaisons chimiothérapiques de drogues se potentialisant. III. Application aux tumeurs primitives du système nerveux central. Nouv. Presse Méd. 4, 713–721.

    CAS  Google Scholar 

  • Ransohoff, J., Martin, B. F., Medrek, T. J., Harris, M. N., Golomb, F. M., Wright, J. C., 1965: Preliminary clinical study of mithramycin (NSC-24559) in primary tumors of the central nervous system. Cancer Chemother. Rep. 49,51–57.

    PubMed  CAS  Google Scholar 

  • Reagan, T. J., Bisel, H. F., Childs, D. S., Layton, D. D., Rhoton, A. L., Taylor, W. F., 1976: Controlled study of CCNU and radiation therapy in malignant astrocytoma. J. Neurosurg. 44, 186–190.

    Article  PubMed  CAS  Google Scholar 

  • Renaudin, J., Fewer, D., Wilson, C. B., Boldrey, E. B., Calogero, J., Enot, K. J., 1973: Dose dependency of Decadron in patients with partially excised brain tumors. J. Neurosurg. 39,302–305.

    Article  PubMed  CAS  Google Scholar 

  • Rieselbach, R. E., Dichiro, G., Freireich, E. J., Rail, D. P., 1962: Subarachnoid distribution of drugs after lumbar injection. New Engl. J. Med. 267,1273–1278.

    Article  PubMed  CAS  Google Scholar 

  • Ringkjeb, R., 1968: Treatment of intracranial gliomas and metastatic carcinomas by local application of cytostatic agents. Acta Neurol. Scand. 44, 318–322.

    Article  Google Scholar 

  • Rosen, J. M., Rosen, F., Milholland, R. J., Nichol, C. H., 1970: Effects of cortisol on DNA metabolism in the sensitive and resistant lines of mouse lymphoma. Cancer Res. 30,1129–1136.

    PubMed  CAS  Google Scholar 

  • Rosenblum, M. L., Bowie, D. L., Walker, M. D., 1973: Diffusion in vitro and in vivo of 1- (2-chloroethyl)-3- (trans-4-methylcyclohexyl)-1-introsourea from silicone rubber capsules, a potentially new mode of chemotherapy administration. Cancer Res. 33, 906–914.

    PubMed  CAS  Google Scholar 

  • Rosenblum, M. L., Reynolds, A. F., Smith, K. A., Rumach, B. H., Walker, M. D., 1973: Chloroethylcycloethyl-introsourea (CCNU) in the treatment of malignant brain tumours. J. Neurosurg. 39, 306–314.

    Article  PubMed  CAS  Google Scholar 

  • Rosenblum, M. L., Wheeler, K. T., Wilson, C. B., Barker, M., Knebel, K. D., 1975: In vitro evaluation of in vivo Brain tumor chemotherapy with 1,3-BIS- (2-chloroethyl)-1-introsourea. Cancer Res. 35, 1387–1391.

    PubMed  CAS  Google Scholar 

  • Rosenblum, M. L., Knebel, K. D., Vasquez, D. A., Wilson, C. B., 1977: Brain-tumor therapy. Quantitative analysis using a model system. J. Neurosurg. 46,145–154.

    Article  PubMed  CAS  Google Scholar 

  • Rosenstock, J. G., Evans, A. E., Schut, L., 1976: Response to vincristine of recurrent brain tumors in children. J. Neurosurg. 45, 135–140.

    Article  PubMed  CAS  Google Scholar 

  • Roth, J. G., Elvidge, A. R., 1960: Glioblastoma multiforme: a clinical survey. J. Neurosurg. 172,736–750.

    Google Scholar 

  • Rubin, R. C., Ommaya, A. K., Henderson, E. S., Bering, E. A., Rall, D. P., 1966: Cerebrospinal fluid perfusion for central nervous system neoplasms. Neurology 16, 680–692.

    PubMed  CAS  Google Scholar 

  • Rubin, R. C., Larson, R., Rall, D. P., 1966: 8-Azaguanine (NSC-749). I. Preclinical toxicity studies and a preliminary report on intrathecal perfusion therapy for patients. Cancer Chemother. Rep. 50,283–286.

    PubMed  CAS  Google Scholar 

  • Rubin, R., Owens, E., Rall, D., 1968: Transport of methotrexate by the choroid plexus. Cancer Res. 13,689–694.

    Google Scholar 

  • Ruderman, N. B., Hall, T. C., 1965: Use of glucocorticoids in paliative treatment of metastatic brain tumors. Cancer 18, 298–306.

    Article  PubMed  CAS  Google Scholar 

  • Serez, R. J., Campbell, R. J., Laws, E. R., Jr., 1977: Chemotherapeutic trials on human malignant astrocytomas in organ culture. J. Neurosurg. 46,320–327.

    Article  Google Scholar 

  • Sano, K., Hoshino, T., Nagai, M., 1968: Radiosensitization of brain tumor cells with a thymidine analogue (Bromouridine). J. Neurosurg. 28,530–538.

    Article  PubMed  CAS  Google Scholar 

  • Sano, K., Hoshino, T., Nagai, M., Tsuchida, T., Sato, F., 1966: Studies on a radiosensitizer (5-Bromo-2Deoxyuridine) in the treatment of malignant brain tumours. Neurol. med. chir. 8,227–231.

    Article  Google Scholar 

  • Sartorelli, A. C., Johns, D. G., 1974: Antineoplastic and Immunosuppressive Agents. Berlin-Heidelberg-New York: Springer. 1974.

    Google Scholar 

  • Schochet, S. S., Lampert, P. W., Earle, K. M., 1968: Neuronal changes induced by intrathecal vincristine sulfate. J. Neuropath. Exp. Neurol. 27, 654–658.

    Article  Google Scholar 

  • Schochet, S. S., Lampert, P. W., Earle, K. M., 1969: Oligodendroglial changes induced by intrathecal vincristine sulfate. Exp. Neurol. 1969, 23, 113–119.

    Article  PubMed  Google Scholar 

  • Seil, F. J., Lampert, P. W., 1968: Neurofibrillary tangles induced by vincristine and vinblastine sulfate in central and peripheral neurons in vitro. Exp. Neurol. 21,219–230.

    Article  PubMed  CAS  Google Scholar 

  • Shapiro, W. R., 1972: Effect of 1-(2-Chloriethyl)-3-cyclohexyl-1-nitrosourea CCNU (NSC-79037) in sesame oil administrated intramuscularly in the treatment of experimental brain tumors. Cancer Chemother. Rep. 56, 457–463.

    PubMed  CAS  Google Scholar 

  • Shapiro, W. R., Ausman, J. I., 1969: The Chemotherapy of Brain Tumors: A Clinical and Experimental Review. In: Recent Advances in Neurology, Chap. IV, 150–235. Edited by F. Plum. Philadelphia: F. A. Davis Company.

    Google Scholar 

  • Shapiro, W. R., Ausman, J. I., Rall, D. P., 1970: Studies on the chemotherapy of experimental brain tumors. Evaluation of 1,3-Bis-(2-Chloriethyl)-1-introsourea, cyclophosphanide, mithramycine, and methotrexate. Cancer Res. 30,2401–2413.

    PubMed  CAS  Google Scholar 

  • Shapiro, W. R., 1971: Studies on the chemotherapy of experimental brain tumors: Evaluation of 1-(2-chloroethyl)-3-cyclotrexyl-1-introsourea, Vincristine and 5-Fluoroceracil. J. Nath. Cancer Inst. 46, 359–368.

    CAS  Google Scholar 

  • Shapiro, W. R.,Chernik, N. L., Posner, J. B., 1973: Necrotizing encephalopathy following intra-ventricular instillation of methotrexate. Arch. Neurol. 28, 96–102.

    PubMed  CAS  Google Scholar 

  • Shapiro, W. R., 1974: The chemotherapy of intracerebral and subcutaneous murine gliomas. Arch. Neurol. 30, 222–226.

    PubMed  CAS  Google Scholar 

  • Shapiro, W. R., Young, D. F., Metha, B. M., 1975: Methotrexate: distribution in cerebrospinal fluid after intravenous ventricular and lumbar injections. N. Engl. J. Med. 293,161–166.

    Article  PubMed  CAS  Google Scholar 

  • Smith, B., 1975: Brain damage after intrathecal metotrexate. J. Neurol. Neurosurg. Psyehiat. 38,810–815.

    Article  CAS  Google Scholar 

  • Stähelin, H., 1970: 4’-Demethyl-epipodopnyllotoxin thenylidene glucoside (VNI26) a podophyllum compound with a new mechanism of action. Europ. J. Cancer 6, 303–311.

    Article  Google Scholar 

  • Sugiura, K., 1967: Effect of 1,3-Bis-(2-chloroethyl)-1-introsourea (NSC 409962) and two related compounds on a spectrum of tumors. Cancer Res. 27, 179–189.

    PubMed  CAS  Google Scholar 

  • Sullivan, R. D., 1962: Continuous arterial infusion. Cancer chemotherapy. Surg. Clin. North Am. 1–32.

    Google Scholar 

  • Tator, C. H., 1971: Uptake of tritiated methotrexate by an experimental glioma. Cancer Res. 31,1600–1605.

    PubMed  CAS  Google Scholar 

  • Tator, C. H., 1972: Chemotherapy of brain tumors. Uptake of tritiated methotrexate by a transplantable intracerebral ependymoblastome in mice. J. Neurosurg. 37, 1–8.

    Article  PubMed  CAS  Google Scholar 

  • Tator, C. H., Wassenaar, W., Day, A., Wei Sum So, 1977: Therapy of an experimental glioma with systemic or intraneoplastic methotrexate or radiation. J. Neurosurg. 46, 175–184.

    Article  PubMed  CAS  Google Scholar 

  • Tator, C. H., Wassenaar, W., 1977: Intraneoplastic injection of methotrexate for experimental brain-tumor chemotherapy. J. Neurosurg. 46, 165–174.

    Article  PubMed  CAS  Google Scholar 

  • Tator, C. H., 1977: Intraneoplastic injection of CCNU for experimental brain tumor chemotherapy. Surg. Neurol. 7, 73–77.

    PubMed  CAS  Google Scholar 

  • Taveras, J. M., Thompson, H. G., Pool, J. L., 1962: Should we treat glioblastoma multiforme? A study of survival in 425 cases. Amer. J. Roentgenol. Radium Ther. Nucl. Med. 87,473–479.

    CAS  Google Scholar 

  • Trabucchi, M., Cerri, C., Spano, P. F., Kumakuua, K., 1977: Guanosine 3’-5’-monophosphate in the CSF of neurological patients. Arch. Neurol. 34,12–13.

    PubMed  CAS  Google Scholar 

  • Ushio, Y., Hayakawa, T., Mogami, H., 1974: Uptake of triated methotrexate by mouse brain tumors after intravenous or intrathecal administration. J. Neurosurg. 40, 706–716.

    Article  PubMed  CAS  Google Scholar 

  • Putten, L. M. van, Keizer, H. J., Mulder, J. H., 1976: Synchronization in tumour chemotherapy. Europ. J. Cancer 12,79–85.

    Google Scholar 

  • Walker, M. D., Hurwitz, B. S., 1970: BCNU (1,3-Bis-(2-Chloroethyl)-1-Nitrosourea; NSC-409962) in the treatment of malignant brain tumor—a preliminary report. Cancer Chemother. Rep. 54,263–271.

    PubMed  CAS  Google Scholar 

  • Walker, M. D., Alexander, E., Jr., Hunt, W. E., Leventhal, L. M., Mahaley, M. S., Jr., Mealey, J., Norrell, H. A., Owens, G., Ransohoff, J., Wilson, C. B., Gehan, E. A., 1976: Evaluation of mithramycin in the treatment of anaplastic gliomas. J. Neurosurg. 44, 655–667.

    Article  PubMed  CAS  Google Scholar 

  • Walker, M. D., Gehan, E. A., 1972: An evaluation of BCNU and irradiation alone and in combination for the treatment of malignant gliomas. Proc. Am. Ass. Cancer Res. 13, 67.

    Google Scholar 

  • Walker, M. D., 1975: Chemotherapy: Adjuvant to surgery and radiation therapy. Seminars in Oncology 2,69–72.

    PubMed  CAS  Google Scholar 

  • Walker, M. D., Strike, T. A., 1976: An evaluation of methyl CCNU, BCNU and radiotherapy in treatment of malignant glioma. Proc. AACR, p. 163.

    Google Scholar 

  • Wassenaar, W., Tator, C. H., Wei Sum So, 1973: The development of an intracerebral glioma model for brain tumor chemotherapy. J. Neurosurg. 39,293–301.

    Article  PubMed  CAS  Google Scholar 

  • Weir, B., Band, P., Urtasun, R., Blain, G., McLean, D., Wilson, F., Mielke, B., Grace, M., 1976: Radiotherapy and CCNU in the treatment of supratentorial astrocytomas. J. Neurosurg. 45, 129–134.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, J. F., Cravioto, H., Bennet, K., Weiss, E. C., Ransohoff, J., 1976: Desmosterol in human and experimental brain tumors in tissue culture. Arch. Neurol. 33, 180–182.

    PubMed  CAS  Google Scholar 

  • Whiteside, J. A., Philips, F. S., Dargeon, H. W., Burcenal, J. H., 1958: Intrathecal amethosterin in neurological manifestations of leukemia. Arch. Intern. Med. 101,279–285.

    CAS  Google Scholar 

  • Willson, N., Duffy, P. E., 1974: Morphologic changes associated with combined BCNU and radiation therapy in glioblastoma multiforme. Neurology 10, 465–471.

    Google Scholar 

  • Wilson, C. B., Weilbaecher, R., McGarry, P., 1963: Characteristics of human brain tumors in tissue cultures and animal host. Surgical Forum 14, 430–431.

    PubMed  CAS  Google Scholar 

  • Wilson, C. B.,1964: Chemotherapy of brain tumors by continuous arterial infusion. Surgery 55, 640–653.

    PubMed  CAS  Google Scholar 

  • Wilson, C. B., Barker, M., 1965: Sensitivity of cell cultures of neural tumors to vinblastine sulfate (NSC-49842). Cancer Chemother. Rep. 44,9–13.

    PubMed  CAS  Google Scholar 

  • Wilson, C. B., Norrell, H., Jr., Barker, M., 1967: Intrathecal injection of methotrexate (NSC-740) in transplanted brain tumors. Cancer Chemother. Rep. 51, 1–5.

    PubMed  CAS  Google Scholar 

  • Wilson, C. B., Hoshino, T., 1969: Current trends in the chemotherapy of brain tumors with special reference to glioblastomas. J. Neurosurg. 31, 589–603.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, C. B., 1969: Current trends in the chemotherapy of brain tumors with special reference to glioblastomas. J. Neurosurg. 31,589–603.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, C. B., Boldrey, E. B., Enot, J. K., 1970: 1,3-Bis-(2-chloroethyl)-1-nitrosourea (N.S.C. 409962) in the treatment of brain tumours. Cancer Chemother. Rep. 54, 273–281.

    PubMed  CAS  Google Scholar 

  • Wilson, C. B., 1976: Chemotherapy of Brain Tumors. In: Advances in Neurology, Vol. 15, p. 361–368. Edited by Thompson, R. A., Green, J. R. Berlin-Heidelberg-New York: Springer.

    Google Scholar 

  • Wilson, C. B., Gutin, P., Boldrey, E. B., Crafts, D., Levin, V. A., Enot, K. J., 1976: Single-agent chemotherapy of brain tumors. Arch. Neurol. 33, 739–744.

    PubMed  CAS  Google Scholar 

  • Wilson, C. B., Yorke, Ch., Jr., Levin, V. A., 1977: Intracranial Malignant Growth, Primary and Metastatic. In: Current Problems in Cancer. Editor Hickey, R. C., Year Book Medical publishers.

    Google Scholar 

  • Wodinsky, I., Kensler, C. J., Rail, D. P., 1969: The induction and transplantation of brain tumors in neonate beagles. Abstracts Am. Assoc. Cancer Res., p. 99.

    Google Scholar 

  • Woodhall, B., Hall, K., Mahaley, S., Jackson, J., 1959: Chemotherapy of brain cancer: experimental and clinical studies in localized hypothermic cerebral perfusion. Ann. Surg. 150,640–652.

    Article  PubMed  CAS  Google Scholar 

  • Woodhall, B., 1960: Brain perfusion. Cancer Chemother. Rep. 10,11–13.

    PubMed  CAS  Google Scholar 

  • Woodhall, B., 1960: Results of perfusion¡ªneural tumors. Cancer Chemother. Rep. 10,93–98.

    PubMed  CAS  Google Scholar 

  • Woodhall, B., Pickrell, K. L., Georgiade, N. G., Mahaley, M. S., Jr., Dukes, H. T., 1960: Effect of hypothermia upon cancer chemotherapy. Application to external cancers of head and face structure. Ann. Surg. 151, 750–759.

    Article  PubMed  CAS  Google Scholar 

  • Wright, R. L., Soloway, A. H., 1961: The efficacy of intracarotid injections. Neurology 11, 922–924.

    Google Scholar 

  • Yohn, D. S., 1972: Oncogenic Viruses: Expectations and Applications in Neuropathology. Progress in Experimental Tumor Research, Vol. 17, p. 74–92. Editor: G. Bingham. Basel: S. Karger.

    Google Scholar 

  • Young, H. F., Sakalas, R., Kaplan, A. M. Ph., 1976: Inhibition of cell-mediated immunity in patients with brain tumors. Surg. Neurol. 5, 19–22.

    PubMed  CAS  Google Scholar 

  • Zagler, R. F., Frisby, S. A., Oliverio, V. T., 1973: The effects of antibiotics and cancer chemotherapic agents on the cellular transport and antitumor activity of methotrexate in LIZIO mur nie leukemia. Cancer Res. 33, 1670–1676.

    Google Scholar 

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Authors and Affiliations

  1. Departments of Internal Medicine and Neurosurgery, Institut Bordet, University of Brussels, Belgium

    J. Hildebrand & J. Brihaye

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  1. J. Hildebrand
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Editors and Affiliations

  1. Zürich, Switzerland

    H. Krayenbühl  & M. G. Yaşargil  & 

  2. Institut Jules Bordet, Centre des Tumeurs de l’Université Libre de Bruxelles, Rue Héger-Bordet, 1, B-1000, Bruxelles, Belgium

    J. Brihaye

  3. Neurochirurgische Universitätsklinik, D-6650, Homburg/Saar, Germany

    F. Loew

  4. London, UK

    V. Logue  & L. Symon  & 

  5. Istituto di Neurochirurgia, Università degli Studi di Padova, Via Giustiniani, 5, I-35100, Padova, Italy

    S. Mingrino

  6. Groupe Hospitalier Pitié-Salpêtrière, Clinique Neuro-Chirurgicale, Université de Paris, 83, Boulevard de l’Hôpital, F-75, Paris 13e, France

    B. Pertuiset

  7. Helsinki, Finland

    H. Troupp

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Hildebrand, J., Brihaye, J. (1978). Chemotherapy of Brain Tumours. In: Krayenbühl, H., et al. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 5. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7062-5_2

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  • DOI: https://doi.org/10.1007/978-3-7091-7062-5_2

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