Stereotactic Radiosurgery in Intracranial Tumours and Vascular Malformations

  • E.-O. Backlund
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 6)


In spite of the recent advances in brain surgery, the operative treatment of many intracranial conditions still offers great technical difficulties. The use of the operating microscope, especially in dextrous hands, considerably increases the possibility of achieving gratifying clinical results, but nevertheless the removal of some brain tumours, even benign, is still attended by considerable risks. Furthermore, arteriovenous malformations may if deep-seated be practically inaccessible to conventional techniques. These technical problems, inherent in traditional operations lend a sense of urgency to the development of new therapeutic methods.


Vascular Malformation Intracranial Tumour Stereotactic Radiosurgery Sella Turcica Radiosurgical Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arndt, J., Backlund, E.-O., Dahlin, H., Ekström, P., 1975: A computer controlled dose planning system for irradiation of small volumes of the brain with a multi cobalt unit. Proc. 3rd Congr. Soc. Radiol. Europ., Edinburgh.Google Scholar
  2. Backlund, E.-O., 1969: Stereotaxic treatment of craniopharyngiomas. In Nobel Symposium 10: Disorders of the skull base region. pp. 237–244. Eds. Hamberger, C.-A., Wersä. 11, J. Stockholm: Almgvist & Wiksell.Google Scholar
  3. Backlund, E.-O., 1973: Studies on craniopharyngiomas. III: Stereotaxic treatment with intracystic yttrium-90. Acta Chir. Seand. 139, 237–247.Google Scholar
  4. Backlund, E.-O., 1977: Treatment of craniopharyngiomas—a 10 year material, 1966–1975. Proc. 6th Int. Congr. Neurol. Surg., Sao Paulo.Google Scholar
  5. Backlund, E.-O., Rähn, T., Sarby, B., de Schryver, A., Wennerstrand, J., 1972 a: Closed stereotaxic hypophysectomy by means of 60Co gamma radiation. Acta Radiol. (Ther. Phys. Biol.) 11, 545–555.Google Scholar
  6. Backlund, E.-O., Johansson, L., Sarby, B., 1972 b: Studies on craniopharyngiomas. II: Treatment by stereotaxis and radiosurgery. Acta Chir. Scand. 138, 749–759.PubMedGoogle Scholar
  7. Backlund, E.-O., Rähn, T., Sarby, B., 1974: Treatment of pinealomas by stereotaxic radiation surgery. Acta Radiol. (Ther. Phys. Biol.) 13, 368–376.Google Scholar
  8. Backlund, E.-O., Arndt, J., Dahlin, H., Greitz, T., Leksell, L., Steiner, L., 1977: Radiosurgery in intracranial arteriovenous malformations. I: Technique. In Neurological Surgery, pp. 162–167. Eds. Carrera, R., Le Vay, D. Amsterdam-Oxford: Excerpta Medica.Google Scholar
  9. Bergström, J., Greitz, T., 1976: Stereotaxic computed tomography. Amer. J. Roentgenol. 127, 167–170.Google Scholar
  10. Brismar, J., 1974: Orbital Phlebography. A method for examination of the intra-orbital veins and the basal sinuses of the skull. Technique and normal anatomy. Acta Radiolog. (Diagn.), Stockholm 15 (4), 369–382.Google Scholar
  11. Brismar, K., Bajraktari, X., Goulatia, R., Efendié, S., 1978: The empty sella syndrome — intrasellar cisternal herniation — in “normal” patients with communicating hydrocephalus and intracranial tumours. Neuroradiology 17, 35–43.PubMedCrossRefGoogle Scholar
  12. Dahlin, H., Rossander, K., Svedberg, J., 1970: On the selection of dose distributions in clinical cerebral radiosurgery. Proc. 9th Symposium Neuroradiologicum, Gothenburg.Google Scholar
  13. Greitz, T., Backlund, E.-O., Bergstrom, M., Boëthius, J., Norén, G., Sundman, R., 1975: Stereotaktisk lokalisation av intrakraniella turnörer med datortomografi. Sv. Fören. f. Neuroradiol., Stockholm.Google Scholar
  14. Hardy, J., Vezina, J. L., 1976: Transsphenoidal neurosurgery of intracranial neoplasm. Adv. Neurol. 15, 261–273.PubMedGoogle Scholar
  15. Johnson, R. T., 1969: Surgery of intracerebral haemorrhage. In Recent advances in neurology and neuropsychiatry, pp. 102–128. London: Churchill.Google Scholar
  16. Jorgensen, L., 1973: Vessel wall and thrombogenesis: Vascular injury, atherosclerosis. Thrombos. Diathes. Haemorrh. ( Stuttgart ). Suppl. 54, 309–316.Google Scholar
  17. Kjellberg, R. N., Kliman, B., 1973: A system for therapy of pituitary tumours. In: Diagnosis and treatment of pituitary tumours, pp. 234–252. Eds. Kohler, P.O., Ross, G. T. Amsterdam: Excerpta Medica.Google Scholar
  18. Kramer, S., Southard, M. Mansfield, C. M., 1968: Radiotherapy in the management of craniopharyngiomas. Amer. J. Roentgenol. 103, 44–52.PubMedGoogle Scholar
  19. Landolt, A. M., 1974: Can craniopharyngiomas be treated by radiotherapy? In: Progr. in pediatric neurosurgery, pp. 232–236. Eds. Bushe, K. A., Spoerri, O., Shaw, J. Stuttgart: Hippokrates.Google Scholar
  20. Larsson, B., Leksell, L., Rexed, B., Sourander, P., Mair, W., Andersson, B., 1958: The high-energy proton beam as a neurosurgical tool. Nature 182, 1222.PubMedCrossRefGoogle Scholar
  21. Lawrence, J. H., Tobias, C. A., Linfoot, J. A., Born, J. L., Chong, C. Y., 1976: Heavy particle therapy in acromegaly and Cushing’s disease. J. A. M. A. 235, 2307–2310.PubMedCrossRefGoogle Scholar
  22. Leksell, L., 1951: The stereotaxic method and radiosurgery of the brain. Acta Chir. Scand. 102, 316–319.PubMedGoogle Scholar
  23. Leksell, L., 1971: Stereotaxis and radiosurgery—an operative system. Springfield, Ill.: Ch. C Thomas.Google Scholar
  24. Leksell, L., 1971: A note on the treatment of acoustic tumours. Acta Chir. Scand. 137, 763–765.PubMedGoogle Scholar
  25. Leksell, L.. Herner, T., Lide’n, K., 1955: Stereotaxic radiosurgery of the brain. Report of a case. Kungl. Fysiogr. Sällsk. Lund Förhandl. 25, 1–10.Google Scholar
  26. Minakova, Y. I., 1977: Personal communication.Google Scholar
  27. Nilsson, A., Wennerstrand, J., Leksell, D., Backlund, E.-O., 1978: Stereotactic gamma irradiation of basilar artery in cat. A pilot study. Acta Radiol. (Oncology) 17, 150–160.Google Scholar
  28. Norén, G., Backlund, E.-O., Grepe, A., Leksell, L., 1979: Stereotactic radiosurgery in acoustic neurinomas. To be published.Google Scholar
  29. Norén, G., Backlund, E.-O., 1977: Treatment of acoustic tumours by stereotactic radiosurgery. Proc. 6th Congr. Neurol. Surg., Sao Paulo.Google Scholar
  30. Rubin, P., Casarett, G. W., 1968: Clinical radiation pathology, Vol. I—II. Philadelphia: W. B. Saunders.Google Scholar
  31. Rähn, T., Thorén, M., Hall, K., Backlund, E.-O., 1979: Acute and short-term effects on pituitary hormone secretion after radiosurgery in patients with pituitary dependent Cushing’s syndrome. To be published.Google Scholar
  32. Sarby, B., Larsson, B., 1965: Fysikaliska experiment rörande förutsättningar for användning av smala gammasträlar vid cerebral strälkirurgi. Report from the Gustaf Werner Institute, Uppsala, Sweden.Google Scholar
  33. Steiner, L., Leksell, L., Greitz, T., Forster, D. M. C., Backlund, E.-O., 1972: Stereotaxic radiosurgery for cerebral arteriovenous malformations. Report of a case. Acta Chir. Scand. 138, 459–464.Google Scholar
  34. Steiner, L., Leksell, L., Forster, D. M. C., Greitz, T., Backlund, E.-O., 1974: Stereo-tactic radiosurgery in intracranial arteriovenous malformations. Acta Neurochir. (Wien), Suppl. 21, 195–209.Google Scholar
  35. Steiner, L., Greitz, T., Leksell, L., Norén, G., Rähn, T., Backlund, E.-O., 1977: Radiosurgery in intracranial arteriovenous malformations. II: A follow-up study. In Neurological Surgery, pp. 168–180. Eds. Carrea, R., Le Vay, D. Amsterdam-Oxford: Excerpta Medica.Google Scholar
  36. Svien, H. J., Peserico, J., 1960: Regression in size of arteriovenous anomaly. J. Neurosurg. 17, 493–496.PubMedCrossRefGoogle Scholar
  37. Thorén, M., Rähn, T., Hall, K., Backlund, E.-O., 1978: Treatment of pituitary dependent Cushing’s syndrome with closed stereotactic radiosurgery by means of 60Co gamma radiation. Acta Endocrinol. 88, 7–17.PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1979

Authors and Affiliations

  • E.-O. Backlund
    • 1
  1. 1.Department of NeurosurgeryKarolinska HospitalStockholmSweden

Personalised recommendations