Profound Arterial Hypotension (MAP ≤50 mm Hg) Induced with Neuroleptanalgesia and Sodium Nitroprusside (Series of 531 Cases). Reference to Vascular Autoregulation Mechanism and Surgery of Vascular Malformations of the Brain

  • B. Pertuiset
  • D. Ancri
  • A. Lienhart
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 8)


The concept of the use of arterial hypotension as an adjuvant in neuro-surgery was first proposed by Cushing in 1917: he observed that in the locally anaesthetized patient haemorrhage during operation was followed by arterial vasoconstriction and subsequently a dry operating field. This observation was radically different from that of Bayliss (1902) who had noticed that arterial hypotension in animals under general anaesthesia was followed by dilatation of the arteries of the brain.


Cerebral Blood Flow Mean Arterial Pressure Sodium Nitroprusside Arteriovenous Malformation Cerebral Blood Volume 
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Copyright information

© Springer-Verlag/Wien 1981

Authors and Affiliations

  • B. Pertuiset
    • 1
  • D. Ancri
    • 1
  • A. Lienhart
    • 1
  1. 1.Clinique Neuro-Chirurgicale, Laboratoire de Médecine Nucléaire, Service d’Anesthésie-Réanimation, Hôpital de la PitiéUniversité ParisParisFrance

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