Outside of and apart from their host cells poliovirions behave like stable inert ribonucleoprotein particles. They appear as if there is no metabolism, none of the dynamic activities that are associated with and are often taken to define living matter. Poliovirus particles can be crystallized and may remain in this stable state almost indefinitely. Only when a virus particle encounters a susceptible host cell, does it “come to life”. With a successful virus-host cell encounter, a dramatic reorganization of the host cell activities begins. Within minutes the virus “takes over command” of the vital host cell metabolic pathways.
KeywordsHeLa Cell Host Cell Tissue Culture Cell Productive Infection Viral Protein Synthesis
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