The first complete virus particles that can be detected within the infected cell by electron microscopy or biological assay appear near the midpoint of the replication cycle: At 2 1/2 to 4 hours post infection, depending on the multiplicity of infection and on the nutritional state of the cell (Kallmann et al., 1958; Dales et al., 1965; Eremenko et al., 1972 a, b). The appearance of the first complete virus particles thus correlates with the time of maximal rates of viral protein and RNA synthesis (Darnell and Levintow, 1960; Darnell et al., 1961) (see Table 32, p. 209).
KeywordsCapsid Protein Empty Shell Assembly Intermediate Smooth Membrane Empty Capsid
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