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Regeneration in the Central Nervous System: Concepts and Facts

  • L. F. Agnati
  • I. Zini
  • M. Zoli
  • K. Fuxe
  • E. Merlo Pich
  • R. Grimaldi
  • G. Toffano
  • M. Goldstein
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 16)

Abstract

In many years, based on Cajal’s statement “… nerve paths are fixed, ended, immutable. Everything may die, nothing may be regenerated…” (Ramon y Cajal 1928) it has been assumed that the central nervous system (CNS) is unable to regenerate a lesioned pathway. Current opinion is in many instances the opposite (Liu and Chambers 1958; Fuxe et al. 1974; Cotman 1978; Björklund and Stenevi 1979). There is now a general belief in possible regeneration in the CNS, even if clearcut results remain scarce (Finger and Almli 1985; Berry 1985). In fact, in some cases, functional recovery after a CNS lesion has been observed and correlated with a morphological readjustment of the neural circuitry. However, a cause-effect link between morphological and functional recovery has not yet been provided, at least not beyond any doubt (Finger and Almli 1985). Since, as a general rule, for both invertebrates and vertebrates, there is little or no further generation of nerve cells in the mature brain, the morphological recovery observed after a lesion must rely on the ability of neurons to form new processes and new contacts (Raisman and Field 1973; Goldberg 1980; Veraa and Grafstein 1981). In fact, neuronal connections are in a dynamic state (morphological plasticity), since also in physiological conditions in the mature brain they are subjected to continuous remodelling (Björklund and Stenevi 1979; Cotman et al. 1981; Cotman and Nieto-Sampedro 1984).

Keywords

Nerve Growth Factor Functional Recovery Nigrostriatal Pathway Nerve Growth Factor mRNA Striatal Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1988

Authors and Affiliations

  • L. F. Agnati
    • 5
  • I. Zini
    • 1
  • M. Zoli
    • 1
  • K. Fuxe
    • 2
  • E. Merlo Pich
    • 1
  • R. Grimaldi
    • 1
  • G. Toffano
    • 3
  • M. Goldstein
    • 4
  1. 1.Department of Human PhysiologyUniversity of ModenaItaly
  2. 2.Department of HistologyKarolinska InstituteStockholmSweden
  3. 3.Fidia Research LaboratoriesAbano TermeItaly
  4. 4.Department of PsychiatryNew York University School of MedicineUSA
  5. 5.Istituto di Fisiologia UmanaUniversitá di ModenaModenaItaly

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