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Adrenal Medullary Transplants as a Treatment for Advanced Parkinson’s Disease

  • A. Lieberman
  • P. R. Cooper
  • J. Ransohoff
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 17)

Abstract

It is no coincidence that human neural transplantation currently focuse on Parkinson’s Disease. In PD, of all the neurodegenerative disorders, there is the clearest relationship between the pathology [the loss of catecholamine containing pigmented neurons in the substantia nigra pars compacta (SNpc)], the neurochemistry [the loss of striatal dopamine (DA)] the pathophysiology (the disinhibition of the striatum), and the clinical symptoms. Moreover, the loss of tissue in PD is small and restricted to the SNpc. It was reasonable to expect that if a transplant could substitute for the lost SNpc neurons in patients with PD, then symptoms might improve.

Keywords

Tyrosine Hydroxylase Caudate Nucleus Neuroleptic Malignant Syndrome Vocal Cord Paralysis Adrenal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lieberman A (1974) Parkinson disease: a clinical review. Am J Med Sci 267: 66 – 80PubMedCrossRefGoogle Scholar
  2. 2.
    Lieberman A (1987) Update on Parkinson disease. NY State J Med 87: 147 – 153Google Scholar
  3. 3.
    Bjorklund A, Schmidt RH, Stenevi U (1980) Functional reinnervation of the neostriatum in the adult rat by use of intraparenchymal grafting of dissociated cell suspensions from the substantia nigra. Cell Tissue Res 212: 39 – 45PubMedCrossRefGoogle Scholar
  4. 4.
    Bjorklund A, Dunnett SB, Stenevi U (1980) Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res 199: 307 – 333PubMedCrossRefGoogle Scholar
  5. 5.
    Olson L, Blacklund EO, Gerhardt G (1986) Nigral and adrenal grafts in parkinsonism. Recent basis and clinical studies. Adv Neurol 454: 85 – 94Google Scholar
  6. 6.
    Freed WJ, Perlow MJ, Karoum F (1980) Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: Long term behavioural, biochemical and histochemical studies. Ann Neurol 8: 510 – 519PubMedCrossRefGoogle Scholar
  7. 7.
    Stromberg I, Bygdeman M, Goldstein M (1986) Human fetal substantia nigra grafted to the dopamine denervated striatum of immunosuppressed rats. Evidence for function reinnervation. Neurosci Lett 71: 271 – 276PubMedCrossRefGoogle Scholar
  8. 8.
    Freed WJ, Morihisa JM, Spoor E (1981) Transplanted adrenal chromaffin cells in rat brain reduce lesion induced rotational behaviour. Nature 2292: 350 – 351Google Scholar
  9. 9.
    Backlund ED, Granberg PO, Hamberger B (1985) Transplantation of adrenal medullary tissue to striatum in parkinsonism. J Neurosurg 62: 169 – 173PubMedCrossRefGoogle Scholar
  10. 10.
    Lindvall O, Backlund ED, Farde L (1987) Transplantation in Parkinson’s disease: two cases of adrenal medullary grafts to the putamen. Ann Neurol 22: 457 – 468PubMedCrossRefGoogle Scholar
  11. 11.
    Madrazo I, Drucker-Colin R, Diaz V (1987) Open microsurgical autograft of adrenal medulla to the right caudate nucleus in patients with intractable Parkinson’s disease. N Engl J Med 316: 831 – 834PubMedCrossRefGoogle Scholar
  12. 12.
    Goetz CG, Olanow CW, Koller WC (1989) Multicenter study of autologous adrenal medullary transplantation to the corpus striatum in patients with advance Parkinson’s disease. N Engl J Med 320: 337 – 341PubMedCrossRefGoogle Scholar
  13. 13.
    Fahn S, Elton RL (1988) Unified Parkinson’s disease rating scale. In: Fahn S, Marsden CD, Calne D, Goldstein M (eds) Recent development in Parkinson’s disease. Macmillan, New York, pp 153 – 163Google Scholar
  14. 14.
    Goldstein M, Lieberman A, Helmer E (1988) Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Ann Neurol 24: 685 – 688PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • A. Lieberman
    • 1
  • P. R. Cooper
    • 1
  • J. Ransohoff
    • 1
  1. 1.New York University Medical CenterNew YorkUSA

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