Clinical and Molecular Neurogenetics in Neurosurgery

  • A. E. Harding
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 20)


This chapter describes the basic principles of molecular genetics, particularly in relation to gene mapping and isolation (positional cloning). The application of this technology is illustrated by progress in elucidating the molecular basis of inherited tumour syndromes, including neurofibromatosis types 1 and 2 and von Hippel-Lindau disease, and molecular studies of tumourigenesis in malignant gliomas.


Acoustic Neuroma Nerve Growth Factor Receptor Plexiform Neurofibroma Lisch Nodule Retinal Angioma 
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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • A. E. Harding
    • 1
  1. 1.Institute of NeurologyLondonUK

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