Advertisement

The Use of GHB in Anticraving Therapy. Preliminary Experimental Data of its Use in Alcohol and Heroin Dependence

  • O. Zolesi
  • L. Daini
  • M. R. Capone
  • M. Aglietti
  • F. Raimondi
  • I. Maremmani
Conference paper

Summary

GHB seems to be an effective anti-craving agent not only in alcoholic patients, as already demonstrated, but also in other drug addiction pathologies. Open studies, carried out at the Dependence-Psychiatry Unit of the Psychiatric Clinic of University of Pisa, showed its effectiveness and lack of side effects when associated with anti-depressants and mood stabilizers, in 20 depressed alcoholic subjects resistant to anti-depressant therapy. The anti-craving effect was also observed in 2 heroin drug addicts, who were abusing alcohol and benzodiazepines during methadone maintenance treatment, and in 4 subjects treated with naltrexone, who were still “craving” heroin. The average observation period was 31 days, the average dosage was 35 ml/die, min 15 max 60; no significant side effects were observed.

Keywords

Alcohol Intake Mood Stabilizer Methadone Maintenance Treatment Opioid Antagonist Global Improvement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gallimberti L, Fern M, Ferrara S D, Fadda F, Gessa G L. Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double-blind study. Alcohol Clin Exp Res 16:673–676, 1992.PubMedCrossRefGoogle Scholar
  2. 2.
    Fadda F, Argiolas A, Melis M R, et al.. Differential effect of acute and chronic ethanol on dopamine metabolism in frontal cortex, caudate nucleus and substantia nigra. Life Sci 27:979–986, 1980.PubMedCrossRefGoogle Scholar
  3. 3.
    Gessa G L. Nascita di un farmaco per l’alcoolismo: l’acido gamma-idrossibutirrico. In: Il GHB nel trattamento della dipendenza alcoolica, edited by Gallimberti L, Ferrarra SD, Gessa GL. Addiction Research Foundation of Italy, Padova, 1992, pp 3–4.Google Scholar

Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • O. Zolesi
    • 1
    • 2
  • L. Daini
    • 1
    • 2
  • M. R. Capone
    • 1
  • M. Aglietti
    • 1
  • F. Raimondi
    • 1
  • I. Maremmani
    • 1
  1. 1.Dependence-Psychiatry Unit, Psychiatric InstituteUniversity of PisaItaly
  2. 2.Ph.D. Research Program SienaPisa & Cagliari UniversitiesItaly

Personalised recommendations