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Drugs of Abuse Craving in Free-Choice Experimental Conditions

  • M. Sala
  • D. Braida
  • M. Colombo
  • M. P. Leone
  • E. Gori

Summary

Given that the techniques used to test drug abuse liability are not free from criticism, a series of oral free-choice experimental procedures was adopted. Firstly, to rats water-deprived for 23h, a choice between pure and fentanyl citrate (5µg/ml) or buprenorphine (25 µg/m1) or etonitazene HC1 (5µg/ml), a very potent µ-opiate, containing aspartame solution, adopted as very potent sweetener, was daily offered. Even if behavioural effects were evident and exhibited tolerance and dependence, no preference was shown. In a second procedure, when the same free-choice was allowed for 24h, no evident behavioural effects and no preference for etonitazene or a stimulant drug, cocaine HCL (300 µg/ml), were detected. However, it was possible to select a group of etonitazene preferring rats. When etonitazene was offered in a free-choice only 1 day over 3, rats exhibited preference versus etonitazene even if evident behavioural effects were absent. Finally, when a gustatory marker (100 µg/ml) was introduced into one of the two solutions, using 1 or 24h schedule, and adopting etonitazene or morphine (500 µg/ml), preference was always shown for the less bitter solution.

Keywords

Withdrawal Syndrome Fentanyl Citrate Drinking Session Morphine Dependence Precipitate Withdrawal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • M. Sala
    • 1
  • D. Braida
    • 1
  • M. Colombo
    • 1
  • M. P. Leone
    • 1
  • E. Gori
    • 1
  1. 1.Institute of Pharmacology, Faculty of Mathematical, Physical and Natural SciencesUniversity of MilanItaly

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