Skip to main content
SpringerLink
Log in

Clinical and pathological characteristics of primary progressive aphasia and frontal dementia

  • Conference paper
New Trends in the Diagnosis and Therapy of Non-Alzheimer’s Dementia

Part of the book series: Journal of Neural Transmission Supplement ((NEURAL SUPPL,volume 47))

Summary

The recently described conditions of primary progressive aphasia and frontal lobe dementia overlap clinically and pathologically to a considerable extent with each other and with clinical and pathological descriptions of Pick’s disease. Our clinical and neuropathological experience is summarized, leading us to the conclusion that the degree of overlap justifies the concept of “Pick complex” to include, in addition to the above, corticobasal ganglionic degeneration and some instances motor neuron disease with dementia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alzheimer A (1907) Über eine eigenartige Erkrankung der Hirntinde. Allg Z Psychiatrie 64: 146–148

    Google Scholar 

  • American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R). American Psychiatric Association, Washington DC

    Google Scholar 

  • Benson DF, Davis RJ, Snyder J (1988) Posterior cortical atrophy. Arch Neurol 45: 789–793

    Article  PubMed  CAS  Google Scholar 

  • Benson DF, Zaias BW (1991) Progressive aphasia: a case with postmortem correlation. Neuropsychiatr Neuropsychol Behav Neurol 4: 115–223

    Google Scholar 

  • Braak H, Braak E (1989) Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia. Neuropathol Appl Neurobiol 15: 13–26

    Article  PubMed  CAS  Google Scholar 

  • Brun A (1987) Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology. Arch Gerontol Geriatr 6: 193–208

    Article  PubMed  CAS  Google Scholar 

  • Caron M (1934) Etude clinique de la maladie Pick. Vigot, Paris

    Google Scholar 

  • Caselli RJ, Windebank AJ, Petersen RC, Komori T, Parisi JE, Okazaki E, Iverson R, Dinapoli RP, Graff-Radford NR, Stein SD (1993) Rapidly progressive aphasic dementia and motor neuron disease. Ann Neurol 33: 200–207

    Article  PubMed  CAS  Google Scholar 

  • Constantinidis J, Richard J, Tissot R (1974) Pick’s disease. Histological and clinical correlations. Eur Neurol 11: 208–217

    Article  PubMed  CAS  Google Scholar 

  • Gustafson L (1987) Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Arch Gerontol Geriatr 6: 209–223

    Article  PubMed  CAS  Google Scholar 

  • Hodges JR, Patterson K, Oxbury S, Funnell E (1992) Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain 115: 1783–1806

    Article  PubMed  Google Scholar 

  • Holland AL, McBurney DH, Moossy J, Reinmuth OM (1985) The dissolution of language in Pick’s disease with neurofibrillary tangles: a case study. Brain Lang 24: 36–58

    Article  PubMed  CAS  Google Scholar 

  • Jagust WJ, Reed BR, Seab JP, Kramer JH, Budinger TF (1989) Clinical-physiologic correlates of Alzheimer’s disease and frontal lobe dementia. Am J Physiol Imag 4: 89–96

    CAS  Google Scholar 

  • Karbe H, Kertesz A, Polk M (1993) Profiles of language impairment in primary progressive aphasia. Arch Neurol 50: 193–201

    Article  PubMed  CAS  Google Scholar 

  • Kertesz A, Appell J, Fisman M (1986) The dissolution of language in Alzheimer’s disease. Can J Neurol Sci 13: 415–418

    PubMed  CAS  Google Scholar 

  • Kertesz A, Davidson W, Fox H (1995) Clinical and behavioral criteria in the diagnosis of frontal lobe dementia. Neurology 45 [Suppl 4]: A273

    Google Scholar 

  • Kertesz A, Hudson L, Mackenzie IRA, Munoz DG (1994) The pathology and nosology of primary progressive aphasia. Neurology 44: 2065–2072

    PubMed  CAS  Google Scholar 

  • Knopman DS, Mastri AR, Frey II WH, Sung JH, Rustan T (1990) Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia. Neurology 40: 251–256

    PubMed  CAS  Google Scholar 

  • Kosaka K, Ikeda K, Kobayashi K, Mehraein P (1991) Striatopallidonigral degeneration in Pick’s disease. J Neurol 238: 151–160

    Article  PubMed  CAS  Google Scholar 

  • Lang AE, Bergeron C, Pollanen MS, et al (1994) Parietal Pick’s disease mimicking corticobasal ganglionic degeneration. Neurology 44: 1436–1440

    PubMed  CAS  Google Scholar 

  • Lippa CF, Cohen R, Smith TW, Drachman DA (1991) Primary progressive aphasia with focal neuronal achromasia. Neurology 41: 882–886

    PubMed  CAS  Google Scholar 

  • Lüers T (1947) Ueber den Verfall der Sprache bei der Pickschen Krankheit (umschniebene Atrophie der Grosshirnrinde). Z Ges Neurol Psychiatrie 179: 94–131

    Article  Google Scholar 

  • Lynch T, Sano M, Marder KS, et al (1994) Clinical characteristics of a family with chromosome 17 linked disinhibition-dementia-parkinsonism-amyotrophy complex. Neurology 44: 1878–1884

    PubMed  CAS  Google Scholar 

  • Mandell AM, Alexander MP, Carpenter S (1989) Creutzfeldt-Jakob disease presenting as isolated aphasia. Neurology 39: 55–58

    PubMed  CAS  Google Scholar 

  • Mesulam MM (1982) Slowly progressive aphasia without dementia. Ann Neurol 11: 592–598

    Article  PubMed  CAS  Google Scholar 

  • Mesulam MM (1987) Primary progressive aphasia — differentiation from Alzheimer’s disease. Ann Neurol 22: 533–534

    Article  PubMed  CAS  Google Scholar 

  • Miller BL, Cummings JL, Villanueva-Meyer J, Boone K, Mehringer CM, Lesser IM, Mena I (1991) Frontal lobe degeneration: clinical, neuropsychological, and SPECT characteristics. Neurology 14: 1374–1382

    Google Scholar 

  • Morris JC, Cole M, Banker BQ, Wright D (1984) Hereditary dysphasic dementia and the Pick-Alzheimer spectrum. Ann Neurol 16: 455–466

    Article  PubMed  CAS  Google Scholar 

  • Neary D, Snowden JS, Bowen DM, Sims NR, Mann DMA, Benton JS, Northen B, Yates PO, Davison AN (1986) Neuropsychological syndromes in presenile dementia due to cerebral atrophy. J Neurol Neurosurg Psychiatry 49: 163–174

    Article  PubMed  CAS  Google Scholar 

  • Neary D, Snowden JS, Mann DMA, Northen B, Goulding PJ, MacDermott N (1990) Frontal lobe dementia and motor neurone disease. J Neurol Neurosurg Psychiatry 53: 23–32

    Article  PubMed  CAS  Google Scholar 

  • Neary D, Snowden JS, Shields RA, Burjan AWI, Northen B, MacDermott N, Prescott MC, Testsa HJ (1987) Single photon emission tomography using 99m Tc-AM-PM in the investigation of dementia. J Neurol Neurosurg Psychiatry 50: 1101–1109

    Article  PubMed  CAS  Google Scholar 

  • Pick A (1892) -Ober die Beziehungen der senilen Hirnatrophie zur Aphasie. Prag Med Wochenschr 17: 165–167

    Google Scholar 

  • Pogacar S, Williams RG (1984) Alzheimer’s disease presenting as slowly progressive aphasia. RI Med J 67: 181–185

    CAS  Google Scholar 

  • Rebeiz JJ, Kolodny EH, Richardson EP Jr (1968) Corticodentatonigral degeneration with neuronal achromasia. Arch Neurol 18: 20–33

    Article  PubMed  CAS  Google Scholar 

  • Rice GPA, Paty DW, Ball MJ, Tatham R, Kertesz A (1980) Spongiform encephalopathy of long duration: a family study. Can J Neurol Sci 7: 171–175

    PubMed  CAS  Google Scholar 

  • Riley DE, Lang AE, Lewis A, Resch L, Ashby P, Horneykiewicz O, Black SI (1990) Cortical-basal ganglionic degeneration. Neurology 40: 1203–1212

    PubMed  CAS  Google Scholar 

  • Rinne JO, Lee MS, Thompson PD, et al (1994) Corticobasal degeneration. A clinical study of 36 cases. Brain 117: 1183–1196

    Article  PubMed  Google Scholar 

  • Rosenfeld M (1909) Die partielle Grosshirnatrophie. J Psychol Neurol 14: 115–130

    Google Scholar 

  • Snowden JS, Goulding PJ, Neary D (1989) Semantic dementia: a form of circumscribed cerebral atrophy. Behav Neurol 2: 167–182

    Google Scholar 

  • Starkstein SE, Migliorelli R, Teson A, Sabe L, Vazquez S, Turjanski M, Robinson RG, Leiguarda R (1994) Specificity of changes in cerebral blood flow in patients with frontal lobe dementia. J Neurol Neurosurg Psychiatry 57: 790–796

    Article  PubMed  CAS  Google Scholar 

  • Tariska I (1970) Circumscribed cerebral atrophy in Alzheimer’s disease: a pathological study. In: Wolstenhome GEW, O’Connor M (eds) Alzheimer disease and related conditions. Churchill, London, pp 51–69

    Google Scholar 

  • The Lund and Manchester Groups (1994) Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 57: 416–418

    Article  Google Scholar 

  • Thompson PD, Marsden CD (1992) Corticobasal degeneration. In: Bailliere’s clinical neurology, vol 1. Bailliere-Tindall, London, pp 677–687

    Google Scholar 

  • Tissot R, Constantinidis J, Richard J (1985) Pick’s disease. In: Frederiks JAM (ed) Handbook of clinical neurology, vol 2 (46). Neurobehavioural disorders. Elsevier, Amsterdam, pp 233–246

    Google Scholar 

  • Wechsler AF (1977) Presenile dementia presenting as aphasia. J Neurol Neurosurg Psychiatry 40: 303–305

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Division of Neuropathology, University of Western Ontario, London, Ontario, Canada

    D. Munoz

  2. Department of Clinical Neurological Sciences, St. Joseph’s Health Centre, University of Western Ontario, London, Ontario, N6A 4V2, Canada

    Dr. A. Kertesz

Authors
  1. Dr. A. Kertesz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Munoz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. L. Boltzmann Institute of Clinical Neurobiology, Lainz-Hospital, Vienna, Austria

    Kurt A. Jellinger

  2. EBEWE-Research Initiative, Graz, Austria

    Manfred Windisch

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag

About this paper

Cite this paper

Kertesz, A., Munoz, D. (1996). Clinical and pathological characteristics of primary progressive aphasia and frontal dementia. In: Jellinger, K.A., Windisch, M. (eds) New Trends in the Diagnosis and Therapy of Non-Alzheimer’s Dementia. Journal of Neural Transmission Supplement, vol 47. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6892-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6892-9_8

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82823-6

  • Online ISBN: 978-3-7091-6892-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation