Skip to main content

Part of the book series: Journal of Neural Transmission Supplement ((NEURAL SUPPL,volume 47))

Summary

Depressive disorder causes cognitive symptoms. In the case of severe cognitive symptoms or when psychometric procedures measure cognitive decline in the range of dementia, depressed patients may be diagnosed as Depressive Pseudo-Dementia (DPD). There is no data that depressive disorder can cause dementia without coexisting depressive symptoms. The latter symptoms are frequently overseen because cognitive symptoms are equated with organic brain disease. There are typical neuropsychological features of cognitive decline in depressive disorders, like psychomotor retardation and the slow-start phenomenon.

Most patients referred to as DPD, suffer from depression-induced cognitive symptoms outside the range of dementia, but complain of memory disturbance and inability to think or concentrate. The diagnosis of DPD draws attention to a problem in the diagnosis of psychiatric disorders in the elderly: Old people suffering from depression are at particular risk of beeing labelled as demented. The most important step to diagnose depression causing dementia is the search for signs and symtoms of affective disorder even after having found cognitive symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alexopoulos GS, Meyers BS, Young RC, Mattis S, Kakuma T (1993) The course of geriatric depression with “reversible dementia”: a controlled study. Am J Psychiatry 150: 1693–1699

    PubMed  CAS  Google Scholar 

  • American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn. APA, Washington DC

    Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. APA, Washington DC

    Google Scholar 

  • Arie T (1983) Pseudodementia. Br Med J 286: 1301–1302

    Article  CAS  Google Scholar 

  • Austin MP, Ross M, Murray C, O’Carroll RE, Ebmeier KP, Goodwin GM (1992) Cognitive function in major depression. J Affect Disord 25: 21–30

    Article  PubMed  CAS  Google Scholar 

  • Bendefeldt F, Miller LL, Ludwig AM (1976) Cognitive performance in conversion hysteria. Arch Gen Psychiatry 33: 1250–1254

    Article  PubMed  CAS  Google Scholar 

  • Blau E, Ober BA (1988) The effect of depression on verbal memory in older adults. J Clin Exp Neuropsychol 10: 81

    Google Scholar 

  • Bleuler E (1916) Lehrbuch der Psychiatrie. Springer, Berlin

    Google Scholar 

  • Brand AN, Jolles J, Gispen-de-Wied C (1992) Recall and recognition memory deficits in depression. J Affect Disord 25: 77–86

    Article  PubMed  CAS  Google Scholar 

  • Bulbena A, Berrios GE (1986) Pseudodementia: facts and figures. Br J Psychiatry 148: 87–94

    Article  PubMed  CAS  Google Scholar 

  • DeRenzi E, Vignolo LA (1962) The Token test: a sensitive test to detect receptive disturbances in aphasics. Brain 85: 665–678

    Article  CAS  Google Scholar 

  • Emery VO, Oxman TE (1992) Update on the dementia spectrum of depression. Am J Psychiatry 149: 305–317

    PubMed  CAS  Google Scholar 

  • Fischer P, Simanyi M, Danielczyk W (1990) Depression in dementia of Alzheimer type and multi-infarct dementia. Am J Psychiatry 147: 1484–1487

    PubMed  CAS  Google Scholar 

  • Folstein MF, Folstein SE, McHugh PR (1975) “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198

    Article  PubMed  CAS  Google Scholar 

  • Fuld PA (1980) Guaranteed stimulus-processing in the evaluation of memory and learning. Cortex 16: 255–271

    PubMed  CAS  Google Scholar 

  • Förstl H (1991) Das Demenzsyndrom der Depression. Neuropsychiatrie 5: 23–25

    Google Scholar 

  • Good MI (1981) Pseudodementia and physical findings masking significant psychopathology. Am J Psychiatry 136: 811–814

    Google Scholar 

  • Huber W, Poeck K, Weninger D, Wilimes K (1982) Aachener Aphasie Test. Hogrefe, Göttingen

    Google Scholar 

  • Kahn RL, Zarit SH, Hilbert NM, Niederehe G (1975) Memory complaint and impairment in the aged. The effect of depression and altered brain function. Arch Gen Psychiatry 32: 1569–1573

    Article  PubMed  CAS  Google Scholar 

  • Kiloh LG (1961) Pseudo-dementia. Acta Psychiatr Scand 37: 336–351

    CAS  Google Scholar 

  • Kraepelin E (1896) Lehrbuch der Psychiatrie. Barth, Leipzig

    Google Scholar 

  • Kral VA (1982) Depressive Pseudodemenz and senile Demenz vom Alzheimertyp. Nervenarzt 53: 284–286

    CAS  Google Scholar 

  • McAllister TW, Price TRP (1982) Severe depressive pseudodementia with and without dementia. Am J Psychiatry 139: 626–629

    CAS  Google Scholar 

  • McAllister TW (1983) Overview: pseudodementia. Am J Psychiatry 140: 528–533

    PubMed  CAS  Google Scholar 

  • McEvoy JP, Wells CE (1979) Case studies in neuropsychiatry II. Conversion pseudodementia. J Clin Psychiatry 40: 447–449

    PubMed  CAS  Google Scholar 

  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34: 939–944

    PubMed  CAS  Google Scholar 

  • Nott PN, Fleminger JJ (1975) Presenile dementia: the difficulties of early diagnosis. Acta Psychiatr Scand 51: 210–217

    Article  PubMed  CAS  Google Scholar 

  • Pearlson GD, Rabins PV, Kim WS, Speedie LJ, Moberg PJ, Burns A, Bascom MJ (1989) Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (“pseudodementia”). Psychol Med 19: 573–584

    Article  PubMed  CAS  Google Scholar 

  • Pettinati HM, Brown M, Mathisen KS (1985) Memory complaints in depressed geriatric inpatients. Ann NY Acad Sci 444: 528–530

    Article  PubMed  CAS  Google Scholar 

  • Pinel P (1798) Nosographie philosophique. Salpêtrière, Paris

    Google Scholar 

  • Rabins PV, Merchant A, Nestadt G (1984) Criteria for diagnosing reversible dementia caused by depression: validation by 2-year follow-up. Br J Psychiatry 144: 488–492

    Article  PubMed  CAS  Google Scholar 

  • Rabins PV (1988) Does reversible dementia exist and is it reversible? Arch Intern Med 148: 1905

    Article  PubMed  CAS  Google Scholar 

  • Reding M, Haycox J, Blass J (1985) Depression in patients referred to a dementia clinic. A three-year prospective study. Arch Neurol 4: 894–896

    Article  Google Scholar 

  • Reifler BV (1982) Arguments for abandoning the term pseudodementia. J Am Geriatr Soc 30: 665–668

    PubMed  CAS  Google Scholar 

  • Reifler BV, Larson E, Hanley R (1982) Coexistence of cognitive impairment and depression in geriatric outpatients. Am J Psychiatry 139: 623–626

    PubMed  CAS  Google Scholar 

  • Richards PM, Ruff RM (1989) Motivational effects on neuropsychological functioning: comparison of depressed versus nondepressed individuals. J Consult Clin Psychol 57: 396–402

    Article  PubMed  CAS  Google Scholar 

  • Sachdev PS, Smith JS, Angus-Lepan H, Rodriguez P (1990) Pseudodementia twelve years on. Neurol Neurosurg Psychiatry 53: 254–259

    Article  CAS  Google Scholar 

  • Shraberg D (1978) The myth of pseudodementia: depression and the aging brain. Am J Psychiatry 135: 601–603

    PubMed  CAS  Google Scholar 

  • Wells CE (1979) Pseudodementia. Am J Psychiatry 136: 895–900

    CAS  Google Scholar 

  • Zimmer R, Lauter H (1984) Zum Problem der depressiven Pseudodemenz. Z Gerontol 17: 109–112

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag

About this paper

Cite this paper

Fischer, P. (1996). The spectrum of depressive pseudo-dementia. In: Jellinger, K.A., Windisch, M. (eds) New Trends in the Diagnosis and Therapy of Non-Alzheimer’s Dementia. Journal of Neural Transmission Supplement, vol 47. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6892-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6892-9_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82823-6

  • Online ISBN: 978-3-7091-6892-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics