Skip to main content
SpringerLink
Log in

Biologische Befunde zur Differentialdiagnose von Demenz und Depression

  • Conference paper
Aktuelle Perspektiven der Biologischen Psychiatrie

  • 76 Accesses

Zusammenfassung

Aufgrund der derzeitigen demographischen Veränderungen mit einem zunehmenden Anteil älterer Menschen an der Gesamtbevölkerung zeigen altersassoziierte Erkrankungen, wie z. B. kardiovaskuläre Erkrankungen und Neoplasien, aber auch psychiatrische Erkrankungen wie Demenzen und Depressionen, dramatisch steigende Prävalenzraten. Im Jahre 1990 gehörten 85.1% der Bevölkerung zu der Gruppe der 0 bis 65-jährigen, 11.1% zu den 65 bis 80-jährigen und 3.8% zu den > 80-jährigen. Im Jahre 2030 wird sich laut bevölkerungsstatistischen Vorausberechnungen eine beachtliche Verlagerung auf Anteile von 73.4%, 20.3% und 6.3% vollziehen (Beske et al. 1994) und somit zu einer weiteren Erhöhung des prozentualen Anteils der älteren Menschen in der Bevölkerung führen und damit auch zu einer weiteren Erhöhung der Häufigkeit der genannten Erkrankungen. Mittlerweile liegt ausreichendes Datenmaterial zu den Häufigkeiten von psychiatrischen Erkrankungen im höheren Lebensalter vor. Eine longitudinale Studie, die in englischen Gemeinden durchgeführt wurde, zeigte altersstandardisierte Prävalenzraten für organische Störungen mit 4.7%, depressive Störungen mit 10.0% und Neurosen mit 2.5% (Saunders et al. 1993). Obwohl die amerikanische „Epidemiologic Catchment Area Study“ einen Abfall der Prävalenzraten für Major Depression im höheren Lebensalter belegte (Regier et al. 1988), gibt es einige Hinweise dafür, daß leichtere Depressionen (Minor Depression), larvierte Depressionen, reaktive Depressionen im Zusammenhang mit somatischen Erkrankungen sowie organische Depressionen höhere Prävalenzraten bei älteren im Vergleich zu jüngeren Bevölkerungsgruppen aufweisen (Angst und Ernst 1993).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 74.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alexopoulos GS, Young RC, Lieberman KW, Shamoian CA (1987) Platelet MAO activity in geriatric patients with depression and dementia. Am J Psychiatry 144 (11): 1480–1483

    PubMed  CAS  Google Scholar 

  • Angst J, Ernst C (1993) Prevalence of affective disorder among the elderly. Proceedings, Lundbeck Symposium, Berlin, September 7, 1993 within the 6th Congress of the International Psychogeriatric Association, pp 5–6

    Google Scholar 

  • Aylward EH, Roberts-Twillie JV, Barta PE, et al (1994) Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry 151 (5): 687–693

    PubMed  CAS  Google Scholar 

  • Beyreuther K, Pollwein P, Multhaup G, Mönning U, König G, Dyrks T, Schubert W, Master CL (1993) Regulation and expression of the Alzheimer’s ß/A4 amyloid protein precursor in health, disease and Down’s sydrome. Ann NY Acad Sci 695: 91–102

    Article  PubMed  CAS  Google Scholar 

  • Braak H, Braak E ( 1991 ) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82 (4): 239–259

    Article  PubMed  CAS  Google Scholar 

  • Beske F (1994) Arbeitskreis Gesundheit im Alter: Kosten-Nutzen-Analysen. Vortrag VI Bonner Symposium, 6/6/94

    Google Scholar 

  • Briley MS, Langer SZ, Raisman R, Sechter D, Zarifian E (1980) Trtiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209: 303–305

    Article  PubMed  CAS  Google Scholar 

  • Chance B, Zhuang Z, Unah C, Alter C, Lipton L (1993) Cognition-activated low frequency modulation of light absorption in human brain. Proc Natl Acad Sci USA 90 (8): 3770–3774

    Article  PubMed  CAS  Google Scholar 

  • Cummings JL (1993) The neuroanatomy of depression. J Clin Psychiatry 54 [Suppl 11]: 14–20

    PubMed  Google Scholar 

  • Emery OV, Oxman TE (1992) Update on the dementia spectrum of depression. Am J Psychiatry 149 (3): 305–317

    PubMed  CAS  Google Scholar 

  • George SM, Ketter RA, Post RM (1993) SPECT and PET imaging in mood disorders. J Clin Psychiatry 54 [Suppl 11]: 6–13

    PubMed  Google Scholar 

  • Ghanbari HA, Miller BE, Chong JK, Haigier H, Whetsell WO (1991) Alzheimer’s disease associated protein (s) in human brain tissue: detection, measurement, specificity and distribution. In: Iqbal K, McLachlan DRC, Winblad B, Wisniewski HM (eds) Alzheimer’s disease: basic mechanisms, diagnosis and treatment. Wiley, New York, pp 568–576

    Google Scholar 

  • Hatzinger M, Brun A, Hemmeter U, Seifritz E, Baumann F, Holsboer-Trachsler E, Heuser IJ (1995) Hypothalamic-pituitary-adrenal system function in patients with Alzheimer’s disease. Neurobiol Aging 16 (2): 205–209

    Article  PubMed  CAS  Google Scholar 

  • Have G, Kolbeinsson H, Petursson H (1991) Dementia and depression in old age: psychophysiological aspects. Acta Psychiatr Scand 83: 329–333

    Article  PubMed  CAS  Google Scholar 

  • Heiss WD, Pawlik G, Holthoff V, Kessler J, Szelies B (1992) PET correlates of normal and impaired memory functions. Cerebrovasc Brain Metab Rev 4: 1–27

    PubMed  CAS  Google Scholar 

  • Heuser I, Yassouridis A, Holsboer F (1994) The combined dexamethasone-/CRH-test: a refined laboratory test for psychiatric disorders. J Psychiat Res 28 (4): 341–356

    Article  PubMed  CAS  Google Scholar 

  • Hock C, Müller-Spahn F, Klages U, Modell S, Bartke I, Naujoks K, Naser W (1993) Quantifizierung des Amyloid-Vorläuferproteins im Liquor von Patienten mit einer Demenz vom Alzheimer Typ. In: Baumann P (Hrsg) Biologische Psychiatrie der Gegenwart. Springer, Wien New York, S 410–416

    Google Scholar 

  • Hock C, Müller-Spahn F, Schuh-Hofer S, Ghidau A, Hofmann M, Dirnagl U, Villringer A (1995a) Age-dependency of changes in cerebral hemoglobin oxygenation during brain activation: a near infrared spectroscopy study. J Cereb Blood Flow Metab 15: 1103–1108

    Article  PubMed  CAS  Google Scholar 

  • Hock C, Golombowksi S, Naser W, Müller-Spahn F (1995b) Increased levels of tau-protein in cerebrospinal fluid of patients with Alzheimer’s disease — correlation with degree of cognitive impairment. Ann Neurol 37 (3): 414–415

    Article  PubMed  CAS  Google Scholar 

  • Hock C, Villringer K, Müller-Spahn F, Hofmann M, Schuh-Hofer S, Heekeren H, Wenzel R, Dirnagl U, Villringer A (1996) Near infrared spectroscopy in the diagnosis of Alzheimer’s disease. Ann NY Acad Sci 777: 22–30

    Article  PubMed  CAS  Google Scholar 

  • Hoshi Y, Tamura M (1993) Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man. Neurosci Lett 150: 5–8

    Article  PubMed  CAS  Google Scholar 

  • Iqbal K, Wang GP, Grundke-Iqbal I, Wisniewski HM (1989) Laboratory diagnostic test for Alzheimer’s disease. Prog Clin Biol Res 371: 679–687

    Google Scholar 

  • Jack CR, Petersen RC, O’Brien PC, Tangalos EG (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42: 183–188

    PubMed  Google Scholar 

  • Kato T, Kamei A, Takshima S, Ozaki T (1993) Human visual cortical functionduring photic stimulation monitoring by means of near-infrared spectroscopy. J Cereb Blood Flow Metab 13: 516–520

    Article  PubMed  CAS  Google Scholar 

  • Krishnan, KRR (1993) Neuroanatomic substrates of depression in the elderly. J Geriatr Psychiatry Neurol 6: 39–58

    PubMed  CAS  Google Scholar 

  • Kumar A (1993) Functional brain imaging in late-life depression and dementia. J Clin Psychiatry 54 [Suppl 11]: 21–25

    PubMed  Google Scholar 

  • Mandelkow EM, Mandelkow E (1993) Tau as marker for Alzheimer’s disease. Trends Biol Sci 18: 480–483

    Article  CAS  Google Scholar 

  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34 (7): 939–944

    PubMed  CAS  Google Scholar 

  • Meller I, Fichter M, Schröppel H, Beck-Eichinger M (1993) Mental and somatic health andneed für care in Octo-and nonagenerians. Eur Arch Psychiatry Clin Neurosci 242: 286–292

    Article  PubMed  CAS  Google Scholar 

  • Meltzer H, Arora R, Baber R, Tricou BJ (1981) Serotonin uptake in blood platelets of psychiatric patients. Arch Gen Psychiatry 38: 1322–1326

    Article  PubMed  CAS  Google Scholar 

  • Moe KE, Larsen LH, Prinz PN, Vitiello (1993) Major unipolar depression and mild Alzheimer’s disease: differentiation by quantitative tonic REM EEG. EEG Clin Neurophysiol 86: 238–246

    Article  CAS  Google Scholar 

  • Regier DA, Boyd JH, Burke JD, et al (1988) One-month prevalence of mental disorders in the United States: based on five Epidemiologic Catchment Area sites. Arch Gen Psychiatry 45: 977–986

    Article  PubMed  CAS  Google Scholar 

  • Reynolds CF, Kupfer DJ, Houck PR, Hoch CC, Stack JA, Berman SR, Zimmer B (1988) Reliable discrimination of elderly depressed and demented patients by electroencephalographic sleep data. Arch Gen Psychiatry 45: 258–264

    Article  PubMed  Google Scholar 

  • Reynolds, CF, Lebowitz BD, Schneider LS (1993) Diagnosis and treatment of depression in late life. Psychopharmacol Bull 29 (1): 83–85

    PubMed  Google Scholar 

  • Reynolds CF, Kupfer DJ, Taska LS, Hock CC, Spiker DG, Sewitch DE, Zimmer B, Marin RS, Nelson JP, Martin D, Morycz R (1995) EEG sleep in elderly depressed, demented, and healthy subjects. Biol Psychiatry 20: 431–442

    Article  Google Scholar 

  • Roth M, Tomlinson B, Blessed G (1967) The relationship between quantitative measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects. Proc R Soc Med 60: 14–20

    Google Scholar 

  • Saunders PA, Copeland JRM, Dewey ME, Gilmore D, Larkin BA, Phaterpekar H, Scott A (1993a) The prevalence of dementia, depression and neurosis in later life: the Liverpool MRC-ALPHA study. Int J Epidemiol 22 (5): 838–847

    Article  PubMed  CAS  Google Scholar 

  • Saunders AM, Strittmatter WJ, Schmechel D, et al (1993b) Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 43: 1467–1472

    PubMed  CAS  Google Scholar 

  • Schenk DB (1995) Therapeutic approaches related to amyloid formation and toxicity. In: Growdon JH, Nitsch RM, Corkin S, Wurtman J (eds) The neurobiology of Alzheimer’s disease. Proceedings, 8th Meeting of the International Study Group on the Pharmacology of Memory Disorders associated with Aging, February 17–19, Zurich, Switzerland, pp 211–214

    Google Scholar 

  • Selkoe DJ (1990) Deciphering Alzheimer’s disease: the amyloid precursor protein yields new clues. Science 248:1058–1060

    Article  PubMed  CAS  Google Scholar 

  • Takeda S, Matsuzawa T (1984) Brain atrophy during aging. J Am Geriatr Soc 32: 520–524

    PubMed  CAS  Google Scholar 

  • Van Nostrand WE, et al (1992) Decreased levels of suluble amyloid β-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci USA 89: 2551–2555

    Article  PubMed  Google Scholar 

  • Vandermeeren M, Mercken M, Vanmechelen E, Six J, Van de Voorde A, Martin JJ, Cras P (1993) Detection of Tau proteins in normal and Alzheimer’s disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. J Neurochem 61 (5): 1828–1834

    Article  PubMed  CAS  Google Scholar 

  • Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U (1993) Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults. Neurosci Lett 154 (1–2): 101–104

    Article  PubMed  CAS  Google Scholar 

  • Wragg RE, Jeste DV (1989) Overview of depression and psychosis in Alzheimer’s disease. Am J Psychiatry 146 (5): 577–587

    PubMed  CAS  Google Scholar 

  • Wyatt JS, Cope M, Delpy DT, Wray S, Reynolds EO (1986) Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry. Lancet 2 (8515): 1063–1066

    Article  PubMed  CAS  Google Scholar 

  • Yamamura, et al (1980) Brain atrophy during aging: a quantitative study with computed tomography. J Gerontol 35: 492–498

    Google Scholar 

  • Zubenko GS (1992) Biological correlates of clinical heterogeneity in primary dementia. Neuropsychopharmacol 6 (2): 77–93

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Psychiatrische Universitätsklinik, Basel, Schweiz

    Prof. Dr. F. Müller-Spahn, M. Hofmann, S. Golombowski & C. Hock

  2. Psychiatrische Klinik, Universität München, Bundesrepublik Deutschland

    U. Hock & H. Hampel

Authors
  1. Prof. Dr. F. Müller-Spahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Hock
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Hofmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Golombowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Hampel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Hock
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrische Klinik, Ludwig-Maximilians-Universität München, Nußbaumstraße 7, D-80336, München, Bundesrepublik Deutschland

    H.-J. Möller

  2. Psychiatrische Klinik, Universität Basel, Wilhelm-Klein-Straße 27, CH-4025, Basel, Schweiz

    F. Müller-Spahn

  3. Bezirkskrankenhaus Augsburg, Dr. Mack Straße 1, D-86156, Augsburg, Bundesrepublik Deutschland

    G. Kurtz

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag/Wien

About this paper

Cite this paper

Müller-Spahn, F., Hock, U., Hofmann, M., Golombowski, S., Hampel, H., Hock, C. (1996). Biologische Befunde zur Differentialdiagnose von Demenz und Depression. In: Möller, HJ., Müller-Spahn, F., Kurtz, G. (eds) Aktuelle Perspektiven der Biologischen Psychiatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6889-9_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6889-9_7

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7425-8

  • Online ISBN: 978-3-7091-6889-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation