Cytokine abnormalities in schizophrenia: a review of their pathogenic significance, with particular reference to the autoimmune hypothesis
Over the past 65 years, a variety of immunologic abnormalities have been reported in association with schizophrenia. These abnormalities have included alterations in lymphocyte subpopulations, alterations in immunoglobulin production both quantitatively and qualitatively, and altered cytokine physiology (for a review see Ganguli etal., 1994). Of these immunologic findings reported in association with schizophrenia, changes in cytokine physiology appear to be the most consistent and uncontroversial. This chapter will focus primarily on the evidence of cytokine abnormalities in a subgroup of patients, and will place these findings in the framework of the hypothesis that, for this subgroup of patients, an autoimmune process may play a pathogenetic role in their disorder. First, however, since this area of research remains mired in controversy and skepticism (DeLisi, 1996), some methodologic issues will be addressed, which pertain to the theoretical and practical aspects of study design and interpretation of results.
KeywordsSchizophrenic Patient Newcastle Disease Virus Immunologic Abnormality Bioi Psychiatry Cytokine Abnormality
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