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Immunological alterations in three types of schizophrenia

  • H. Fabisch
  • K. Fabisch
  • H. G. Zapotoczky
  • G. P. Tilz
  • G. Langs
  • U. Demel
  • G. Wieselmann
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Abstract

Immunological blood serology has been showing a manifold picture of pathological changes in patients suffering from schizophrenic disorders (DeLisi, 1986). The focus of scientific investigation has been set on zytokines and their receptors (Ganguli and Rabin, 1989; Goldstein etal., 1980; Müller etal., 1990; Villemain etal., 1989). The examination of immunoglobulins, especially antibodies against neuronal tissue (Henneberg etal., 1994), is an important part of the question, in how far immunological changes may have a causal relationship to the development of schizophrenic disorders. Another important issue concerns the search for the significance of antinuclear factors (Noy et al., 1994; O’Donnel et al., 1988; Villemain et al., 1989). Altogether the findings are rather heterogenous and there are many schizophrenic patients showing normal serological parameters.

Keywords

Schizophrenic Patient Immune Parameter Undifferentiated Type Organic Brain Syndrome Immunological Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn, DSM-IV. APA, Washington DCGoogle Scholar
  2. DeLisi LE (1986) Neuroimmunology: clinical studies of schizophrenia and other psychiatric disorders. In: Nasrallah HA, Weinberger DK (eds) The neurology of schizophrenia. Elsevier, Amsterdam, pp 377–396 (Handbook of schizophrenia, vol 1 )Google Scholar
  3. Ganguli R, Rabin B (1989) Increased serum interleukin 2 receptor concentration in schizophrenia and brain damaged subjects. Arch Gen Psychiatry 46: 292PubMedGoogle Scholar
  4. Goldstein AL, Rossio J, Kolyaskina GL, Emory LE, Overall JE, Thurman GB, Hatcher I (1980) Immunological components in schizophrenia. In: Baxter C, Menechuk T (eds) Perspectives in schizophrenia research. Raven Press, New York, pp 249 – 262Google Scholar
  5. Henneberg AE, Horter S, Ruffert S (1994) Increased prevalence of antibrain antibod¬ies in the sera from schizophrenic patients. Schizophr Res 14: 1 – 22CrossRefGoogle Scholar
  6. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261 – 276PubMedGoogle Scholar
  7. Müller N, Hofschuster E, Ackenheil M (1990) Zellulares Immunsystem und Psycho- pathologie bei Schizophrenen. In: Kaschka WP, Aschauer HN (eds) Psychoim- munologie. Thieme, Stuttgart, pp 116 – 125Google Scholar
  8. Noy S, Achiron A, Laor N (1994) Schizophrenia and autommunity - a possible etiological mechanism? Neuropsychobiology 30: 157 – 159PubMedCrossRefGoogle Scholar
  9. O’Donnel M, Silove D, Wakefield D (1988) Current perspectives on immunology and psychiatry. Aust N Z J Psych 22: 366 – 382CrossRefGoogle Scholar
  10. Tilz GP (1993) Klinische Immunbiologie und Immunhamatologie. In: Begemann H, Rastetter J (Hrsg) Klinische Hamatologie. Thieme, Stuttgart New York, pp 118 – 163Google Scholar
  11. Villemain F, Chatenoud L, Galinowski A, Homo-Delarche F, Ginstet D, Loo H, Zarifan E (1989) Aberrant T cell-mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production. Am J Psychiatry 146: 609 – 616PubMedGoogle Scholar
  12. Wieselmann G, Fabisch H, Tilz G, Herzog G, Fabisch K, Langs G, Zapotoczky HG (1995) “Chronische Schizophrenic” oder “Organisches Psychosyndrom”? In: Platz T, König P, Schubert H (Hrsg) Betroffen von Schizophrenic. Edition pro mente, Linz, pp 137–143Google Scholar

Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • H. Fabisch
    • 1
  • K. Fabisch
    • 1
  • H. G. Zapotoczky
    • 1
  • G. P. Tilz
    • 1
  • G. Langs
    • 1
  • U. Demel
    • 2
  • G. Wieselmann
    • 1
  1. 1.Department of PsychiatryUniversity of GrazAustria
  2. 2.Department of Clinical ImmunologyUniversity of GrazAustria

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