Abstract
Immunological blood serology has been showing a manifold picture of pathological changes in patients suffering from schizophrenic disorders (DeLisi, 1986). The focus of scientific investigation has been set on zytokines and their receptors (Ganguli and Rabin, 1989; Goldstein etal., 1980; Müller etal., 1990; Villemain etal., 1989). The examination of immunoglobulins, especially antibodies against neuronal tissue (Henneberg etal., 1994), is an important part of the question, in how far immunological changes may have a causal relationship to the development of schizophrenic disorders. Another important issue concerns the search for the significance of antinuclear factors (Noy et al., 1994; O’Donnel et al., 1988; Villemain et al., 1989). Altogether the findings are rather heterogenous and there are many schizophrenic patients showing normal serological parameters.
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References
American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn, DSM-IV. APA, Washington DC
DeLisi LE (1986) Neuroimmunology: clinical studies of schizophrenia and other psychiatric disorders. In: Nasrallah HA, Weinberger DK (eds) The neurology of schizophrenia. Elsevier, Amsterdam, pp 377–396 (Handbook of schizophrenia, vol 1 )
Ganguli R, Rabin B (1989) Increased serum interleukin 2 receptor concentration in schizophrenia and brain damaged subjects. Arch Gen Psychiatry 46: 292
Goldstein AL, Rossio J, Kolyaskina GL, Emory LE, Overall JE, Thurman GB, Hatcher I (1980) Immunological components in schizophrenia. In: Baxter C, Menechuk T (eds) Perspectives in schizophrenia research. Raven Press, New York, pp 249 – 262
Henneberg AE, Horter S, Ruffert S (1994) Increased prevalence of antibrain antibod¬ies in the sera from schizophrenic patients. Schizophr Res 14: 1 – 22
Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261 – 276
Müller N, Hofschuster E, Ackenheil M (1990) Zellulares Immunsystem und Psycho- pathologie bei Schizophrenen. In: Kaschka WP, Aschauer HN (eds) Psychoim- munologie. Thieme, Stuttgart, pp 116 – 125
Noy S, Achiron A, Laor N (1994) Schizophrenia and autommunity - a possible etiological mechanism? Neuropsychobiology 30: 157 – 159
O’Donnel M, Silove D, Wakefield D (1988) Current perspectives on immunology and psychiatry. Aust N Z J Psych 22: 366 – 382
Tilz GP (1993) Klinische Immunbiologie und Immunhamatologie. In: Begemann H, Rastetter J (Hrsg) Klinische Hamatologie. Thieme, Stuttgart New York, pp 118 – 163
Villemain F, Chatenoud L, Galinowski A, Homo-Delarche F, Ginstet D, Loo H, Zarifan E (1989) Aberrant T cell-mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production. Am J Psychiatry 146: 609 – 616
Wieselmann G, Fabisch H, Tilz G, Herzog G, Fabisch K, Langs G, Zapotoczky HG (1995) “Chronische Schizophrenic” oder “Organisches Psychosyndrom”? In: Platz T, König P, Schubert H (Hrsg) Betroffen von Schizophrenic. Edition pro mente, Linz, pp 137–143
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Fabisch, H. et al. (1997). Immunological alterations in three types of schizophrenia. In: Wieselmann, G. (eds) Current Update in Psychoimmunology. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6870-7_5
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DOI: https://doi.org/10.1007/978-3-7091-6870-7_5
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