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Platelet Antibodies In Mental Disorder

  • K. Schott
  • M. Schnaidt
  • A. Batra
  • M. Bartels
  • G. Buchkremer
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Abstract

Platelets are a model for monoamine containing neurons in the CNS (Sneddon, 1973; Pletcher etal., 1984). Serotonin and dopamine uptake mechanisms are well established in this model (Lingjaerde, 1977; Gordon and Overman, 1978; Omenn and Smith, 1978; Lingjaerde and Kildemo, 1981). Shinitzky and co-workers (1991) first demonstrated platelet associated antibodies (PAA) in schizophrenia and dementia which crossreacted with brain tissue from rats. Kessler and Shinitzky (1993) showed that PAA from schizophrenic patients specifically inhibited the uptake of dopamine by platelets and interfered with the dopamine receptor ligands [3H]-dopamine and [3H]-spiperone at rat brain P2m membranes. The authors suggested that blood platelets may function as a peripheral epitope for the formation of PAA, which, when reaching the brain, may react with the dopamine receptor and elicit mental disorder. In this context alterations of the immune status with occurrence of autoantibodies in schizophrenia are known for decades (Brauchitsch, 1972; DeLisi et al., 1985; Stein etal., 1987). In this study we investigated the formation of anti platelet antibodies in patients with various mental disorders.

Keywords

Schizophrenic Patient Autoimmune Process Paranoid Schizophrenia Dopamine Uptake Platelet Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • K. Schott
    • 1
  • M. Schnaidt
    • 2
  • A. Batra
    • 1
  • M. Bartels
    • 1
  • G. Buchkremer
    • 1
  1. 1.Universitätsklinik für Psychiatric und PsychotherapieTübingenFederal Republic of Germany
  2. 2.Abteilung fur TransfusionsmedizinTübingenFederal Republic of Germany

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