Psychoneuroimmunology and neuroendocrinology — an integrative view

  • W. P. Kaschka
Part of the Key Topics in Brain Research book series (KEYTOPICS)


A paper with the title “lnfectio psychica” was published as early as 1846 in the Österreichische Medizinische Wochenschrift (Austrian Weekly Medical Journal) (Hofbauer, 1846). Hofbauer speculated that psychiatric illnesses may possibly be transmitted by infection. This hypothesis was also adopted by others in the following decades, e.g. by Baillarger (1857) and Wollenberg (1889). This approach was further pursued by various authors in the 20th century: a virus hypothesis was formulated to explain endogenous psychoses (for review see Kaschka, 1989). Three major strategies of research resulted from this hypothesis:
  1. 1.

    Antibody studies in serum and CSF with a view to detecting local (autochthonous) immunoglobulin synthesis in the central nervous system (CNS).

  2. 2.

    Detectiomn of intact viruses, viral nucleic acid or viral antigens in brain tissue (biopy or autopsy material) or CSF.

  3. 3.

    Investigations on transmission to experimental animals using brain tissue or CSF.



Systemic Lupus Erythematosus Corticotropin releaSing Hormone Viral Nucleic Acid Pokeweed Mitogen Bidirectional Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • W. P. Kaschka
    • 1
  1. 1.Abteilung Psychiatrie IUniversität Ulm, und Zentrum für Psychiatrie WeissenauRavensburg-WeisseauFederal Republic of Germany

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