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Apolipoprotein E gene in Parkinson’s disease, Lewy body dementia and Alzheimer’s disease

  • D. St. Clair
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 51)

Summary

Apolipoprotein E (Apo E) epsilon 4 allele is a risk factor for early and late onset Alzheimer’s disease. This prompted us to examine other neurophyschiatric phenotypes. Epsilon 4 allele was significantly enriched in Lewy body dementia (N = 39) but not in Parkinson’s disease (n = 50) or Schizophrenia (n = 175) compared to aged non-demented controls (n = 47) and the Scottish population (n = 400). We conclude that Lewy body disease should be regarded as a variant of Alzheimer’s but not Parkinson’s disease.

Keywords

Neurofibrillary Tangle Polymerase Chain Reac Lewy Body Disease Lewy Body Dementia Scottish Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • D. St. Clair
    • 1
  1. 1.Department of Mental HealthUniversity of AberdeenAberdeenUK

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