The relationship of Alzheimer-type pathology to dementia in Parkinson’s disease

  • K. Jendroska
Conference paper


Lewy body degeneration of the subcortical nuclei other than the substantia nigra is common in PD and may represent the substrate for a higher vulnerability to dementia in patients with PD. Cortical pathologies of Alzheimer and Lewy body type seem to be the major determinants of dementia. The prevalence of Alzheimer’s disease is not increased in PD, but “early” cortical Alzheimer lesions (usually sub-clinical in normal controls) are frequently associated with dementia in PD. Furthermore, dementia in PD is heterogeneous and should always prompt the clinician to search for treatable causes.


Multiple System Atrophy Lewy Body Alzheimer Pathology Normal Pressure Hydrocephalus Subcortical Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • K. Jendroska
    • 1
  1. 1.Department of NeurologyUniversity Clinic CharitéBerlinGermany

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