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Advances in Research on Neurodegeneration pp 23–31Cite as

The relationship of Alzheimer-type pathology to dementia in Parkinson’s disease

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Summary

Lewy body degeneration of the subcortical nuclei other than the substantia nigra is common in PD and may represent the substrate for a higher vulnerability to dementia in patients with PD. Cortical pathologies of Alzheimer and Lewy body type seem to be the major determinants of dementia. The prevalence of Alzheimer’s disease is not increased in PD, but “early” cortical Alzheimer lesions (usually sub-clinical in normal controls) are frequently associated with dementia in PD. Furthermore, dementia in PD is heterogeneous and should always prompt the clinician to search for treatable causes.

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Author information

Authors and Affiliations

  1. Department of Neurology, University Clinic Charité, Schumannstrasse 20/21, D-10117, Berlin, Germany

    K. Jendroska M.D.

Authors
  1. K. Jendroska M.D.
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Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  2. Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim (Faculty of Medicine) (Faculty of Medicine)

  3. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  4. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  5. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  6. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

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© 1997 Springer-Verlag/Wien

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Jendroska, K. (1997). The relationship of Alzheimer-type pathology to dementia in Parkinson’s disease. In: Mizuno, Y., Youdim, M.B.H., Calne, D.B., Horowski, R., Poewe, W., Riederer, P. (eds) Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6844-8_3

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  • DOI: https://doi.org/10.1007/978-3-7091-6844-8_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82934-9

  • Online ISBN: 978-3-7091-6844-8

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