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Apoptosis in neurodegenerative disorders: potential for therapy by modifying gene transcription

  • Conference paper
Advances in Research on Neurodegeneration

Summary

Apoptotic, rather than necrotic, nerve cell death now appears as likely to underlie a number of common neurological conditions including stroke, Alzheimer’s disease, Parkinson’s disease, hereditary retinal dystrophies and Amyotrophic Lateral Sclerosis. Apoptotic neuronal death is a delayed, multistep process and therefore offers a therapeutic opportunity if one or more of these steps can be interrupted or reversed. Research is beginning to show how specific macromolecules play a role in determining the apoptotic death process. We are particularly interested in the critical nature of gradual mitochondrial failure in the apoptotic process and propose that a maintenance of mitochondrial function through the pharmacological modulation of gene expression offers an opportunity for the effective treatment of some types of neurological dysfunction.

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  1. Dr. W. G. Tatton

    Present address: The Institute for Neuroscience, Dalhousie University, B3H4H7, Halifax, Nova Scotia, Canada

Authors and Affiliations

  1. Department of Physiology/Biophysics, Dalhousie University, B3H4H7, Halifax, Nova Scotia, Canada

    Dr. W. G. Tatton, R. M. E. Chalmers-Redman, W. Y. H. Ju & J. Wadia

  2. Department of Psychology, Dalhousie University, B3H4H7, Halifax, Nova Scotia, Canada

    Dr. W. G. Tatton

  3. Department of Pharmacology, Dalhousie University, B3H4H7, Halifax, Nova Scotia, Canada

    N. A. Tatton

  4. The Institute for Neuroscience, Dalhousie University, B3H4H7, Halifax, Nova Scotia, Canada

    R. M. E. Chalmers-Redman & N. A. Tatton

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  3. W. Y. H. Ju
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Editors and Affiliations

  1. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  2. Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim (Faculty of Medicine) (Faculty of Medicine)

  3. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  4. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  5. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  6. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

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© 1997 Springer-Verlag/Wien

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Tatton, W.G., Chalmers-Redman, R.M.E., Ju, W.Y.H., Wadia, J., Tatton, N.A. (1997). Apoptosis in neurodegenerative disorders: potential for therapy by modifying gene transcription. In: Mizuno, Y., Youdim, M.B.H., Calne, D.B., Horowski, R., Poewe, W., Riederer, P. (eds) Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6844-8_25

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  • DOI: https://doi.org/10.1007/978-3-7091-6844-8_25

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82934-9

  • Online ISBN: 978-3-7091-6844-8

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