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Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias

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Advances in Research on Neurodegeneration

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Summary

During the past decade, converging lines of evidence have linked the abnormal release or leak of excitatory amino acids to the neurodegeneration associated with a wide range of pathologies including cerebral ischemias, Huntington’s disease, and AIDS dementia (Coyle and Robinson, 1987; Lipton, 1994; Meldrum, 1994). Pharmacological studies indicate that activation of both ionotropic and metabotropic glutamate receptors can substantially contribute to excitotoxic cell damage (Choi, 1992; Pizzi et al, 1993; Sheardown et al., 1993; Xue et al., 1994). Based on these findings, therapeutic strategies based on blunting or blocking glutamatergic transmission may be useful in treating a variety of neurodegenerative disorders.

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Author information

Author notes

  1. Dr. P. Skolnick

    Present address: Laboratory of Neuroscience, NIH, NIDDK/LN, Building 8, Room 111, Bethesda, MD, 20892, USA

Authors and Affiliations

  1. Laboratory of Neuroscience, NIH, NIDDK/LN, Building 8, Room 111, Bethesda, MD, 20892, USA

    L. H. Fossom

Authors
  1. L. H. Fossom
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  2. Dr. P. Skolnick
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Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  2. Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim (Faculty of Medicine) (Faculty of Medicine)

  3. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  4. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  5. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  6. Department of Psychiatry, University of WĂĽrzburg, Federal Republic of Germany

    P. Riederer

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© 1997 Springer-Verlag/Wien

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Fossom, L.H., Skolnick, P. (1997). Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias. In: Mizuno, Y., Youdim, M.B.H., Calne, D.B., Horowski, R., Poewe, W., Riederer, P. (eds) Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6844-8_24

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  • DOI: https://doi.org/10.1007/978-3-7091-6844-8_24

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82934-9

  • Online ISBN: 978-3-7091-6844-8

  • eBook Packages: Springer Book Archive

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