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Central nervous system cytokines and their relevance for neurotoxicity and apoptosis

  • J. Licinio

Summary

Cytokines are molecules that are synthesized not only by the immune system, but also by cells in the central nervous system, including neurons, glia, and brain vascular cells. In the brain, cytokines can be neuroprotective or they can contribute to neurodegeneration. The role of cytokines in the regulation of normal and abnormal brain function represents a rapidly growing frontier in neuroscience. Cytokines are pleiotropic and redundant, and they can modulate the effects of neurotransmitters and neuropeptides; thus, in order to understand the effects of brain cytokines on apoptosis and toxicity, it is necessary to study the temporal and spatial expression of complex networks of cytokines, growth factors, neuropeptides, and neurotransmitters. This effort is currently in progress in many centers. Modulation of cytokine function in the central nervous system represents a new therapeutic strategy for neurodegeneration.

Keywords

Middle Cerebral Artery Occlusion Neuronal Cell Death Polyglutamine Tract Ischemic Cortex Nerve Growth Factor mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • J. Licinio
    • 1
  1. 1.CNE, NIMHNIHBethesdaUSA

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