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From prion diseases to Alzheimer’s disease

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Advances in Research on Neurodegeneration

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Summary

Recent advances in the transgenetics of prion diseases and Alzheimer’s disease have led to a clearer understanding of the relationship between these two diseases and the pathogenic mechanisms underlying the two disorders. Earlier studies of transgenic mice expressing prion protein (PrP) underscored the importance of PrP levels and PrP primary structure on the resultant phenotype. Three major parameters influencing the phenotypes of mice expressing the Alzheimer amyloid precursor protein (APP) have also been identified: 1) APP levels; 2) APP primary structure; and 3) mouse host strain. The effects and implications of these parameters in transgenic mice expressing APP are discussed.

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Author information

Authors and Affiliations

  1. Department of Neurology, University of Minnesota, Box 295 UMHC, 420 Delaware Street, SE, Minneapolis, MN, 55455, USA

    K. K. Hsiao M.D. Ph.D.

Authors
  1. K. K. Hsiao M.D. Ph.D.
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Editor information

Editors and Affiliations

  1. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  2. Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim (Faculty of Medicine) (Faculty of Medicine)

  3. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  4. Clinical Research, Schering AG, Berlin, Federal Republic of Germany

    R. Horowski

  5. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  6. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer

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© 1997 Springer-Verlag/Wien

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Hsiao, K.K. (1997). From prion diseases to Alzheimer’s disease. In: Mizuno, Y., Youdim, M.B.H., Calne, D.B., Horowski, R., Poewe, W., Riederer, P. (eds) Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6844-8_15

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  • DOI: https://doi.org/10.1007/978-3-7091-6844-8_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82934-9

  • Online ISBN: 978-3-7091-6844-8

  • eBook Packages: Springer Book Archive

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