IBZM- and CIT-SPECT of the dopaminergic system in parkinsonism
Parkinsonism is most of the time caused by idiopathic Parkinson’s disease (IPD). Considering the differences in therapeutic response and prognosis, in vivo discrimination between IPD and “parkinsonism-plus” syndromes is important. Recently, ligands have become available for imaging the pre- and postsynaptic dopaminergic system by Single Photon Emission Computed Tomography (SPECT). Visualization of postsynaptic D2 dopamine receptors using 123I-iodobenzamide (123I-IBZM) may contribute to the differential diagnosis between IPD and “parkinsonism-plus” syndromes as IPD is a pure presynaptic disease. Imaging of the presynaptic dopamine transporters using [123I]β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) may be used as a diagnostic technique. Early disease detection in subjects suspected to be at risk for developing IPD has become possible using [123I]β-CIT or other ligands for the dopamine transporter. Furthermore, with SPECT one is probably able to monitor in an objective way the efficacy of new pharmacological therapies.
KeywordsSingle Photon Emission Compute Tomography Multiple System Atrophy Single Photon Emission Compute Tomography Imaging Progressive Supranuclear Palsy Single Photon Emission Compute Tomography Study
Unable to display preview. Download preview PDF.
- Booij J, Vermeiden RJ, Tissingh G, et al (1995) Visualization of the dopamine transporter in Parkinson’s disease and multiple system atrophy: a [123–1]ß-CIT study. Acta Neurol Belg 95 [Suppl]: 35Google Scholar
- Brooks DJ, Salmon EP, Mathias CJ, et al (1990b) The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson’s disease, studied with PET. Brain 113: 1539–1552PubMedCrossRefGoogle Scholar
- Brücke T, Wenger S, Asenbaum S, et al (1993) Dopamine D2 receptor imaging and measurement with SPECT. In: Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y (eds) Advances in Neurology, vol 60. Raven Press, New YorkGoogle Scholar
- Neumeyer JL, Wang S, Gao Y, et al (1994) N-3-fluoroalkyl analogs of (lR)-2ß-carbomethoxy-3ß-(4-iodophenyl)-tropane (ß-CIT) radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters. J Med Chem 37: 1558–1561PubMedCrossRefGoogle Scholar
- Oertel WH, Schwarz J, Tatsch K, Arnold G, Gasser T, Kirsch C-M (1993) IBZM-SPECT as predictor for dopamimetic responsiveness of patients with de novo parkinsonian syndrome. In: Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y (eds) Advances in neurology, vol 60. Raven Press, New YorkGoogle Scholar
- Quinn N (1989) Multiple system atrophy — the nature of the beast. J Neurol Neurosurg Psychiatry [spec Suppl] 78–89Google Scholar
- Van Royen E, Verhoeff NFLG, Speelman JD, Wolters EC, Kuiper MA, Janssen AGM (1993) Multiple system atrophy and progressive supranuclear palsy. Diminished striatal D2 dopamine receptor activity demonstrated by 123I-IBZM single photon emission computed tomography. Arch Neurol 50: 513–516PubMedCrossRefGoogle Scholar
- Verhoeff NPLG, Buell U, Costa DC, et al (1992) Basics and recommendations for brain SPECT. Nuklearmedizin 31: 114–131Google Scholar