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rCBF SPECT in Parkinson’s disease patients with mental dysfunction

  • Conference paper
Book cover Advances in Research on Neurodegeneration

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 50))

Summary

Functional imaging of the brain using SPECT provides information correlative to the alterations of regional blood flow. In this paper we review the literature pertaining to SPECT in Parkinson’s disease with and without dementia and depression. Parkinson’s disease itself is not associated with a consistent pattern of cerebral blood flow alterations in the basal ganglia, but reduced parietal blood flow is more often reported. The heterogeneity of blood flow changes possibly reflects the multifactorial pathophysiology of the disease. In demented Parkinson’s disease patients frontal hypoperfusion is often found or bilateral temporoparietal deficits, probably indicative of concommitant Alzheimer’s disease. The SPECT studies undertaken in depressed patients with and without Parkinsons’s disease show highly conflicting and inconsistent results, probably due to methodological and diagnostic flaws (especially the inclusion of demented Parkinson patients). Several lines of reasoning point to a prefrontal dysfunction and future SPECT studies are planned to study this region in non-demented Parkinson’s disease patients with and without major depression.

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Author notes

  1. Dr. S. Bissessur

    Present address: Department of Neurology, Academisch Ziekenhuis VU Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands

Authors and Affiliations

  1. Department of Neurology, Academisch Ziekenhuis VU Amsterdam, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands

    G. Tissingh, E. Ch. Wolters & Ph. Scheltens

Authors
  1. Dr. S. Bissessur
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  2. G. Tissingh
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  3. E. Ch. Wolters
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  4. Ph. Scheltens
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Würzburg, Germany

    P. Riederer

  2. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  3. Clinical Research, Schering AG, Berlin, Germany

    R. Horowski

  4. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  5. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  6. Faculty of Medicine, Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim

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© 1997 Springer-Verlag Wien

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Bissessur, S., Tissingh, G., Wolters, E.C., Scheltens, P. (1997). rCBF SPECT in Parkinson’s disease patients with mental dysfunction. In: Riederer, P., Calne, D.B., Horowski, R., Mizuno, Y., Poewe, W., Youdim, M.B.H. (eds) Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementa, vol 50. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6842-4_3

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  • DOI: https://doi.org/10.1007/978-3-7091-6842-4_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82898-4

  • Online ISBN: 978-3-7091-6842-4

  • eBook Packages: Springer Book Archive

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