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Update on management and genetics of multiple sclerosis

  • A. Dessa Sadovnick
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 50)

Summary

Although the exact etiology of multiple sclerosis (MS) remains uncertain, there is an increasing body of evidence to support the role of genetic factors in MS susceptibility in general and the familial aggregation of MS in particular.

MS management continues to be largely symptom-specific. MS relapses are now frequently treated with IV-methylprednisone. In recent years, MS treatment trials are being conducted throughout the world. Interferon beta-lb has been approved as the first ongoing therapy for relapsing/remitting MS, although some issues/concerns remain to be addressed.

In summary, while much research is still needed, important progress is being made in unravelling the etiology of MS and in developing management protocols which are not symptom- or relapse-specific.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Familial Aggregation Multiple Sclerosis Relapse Multiple Sclerosis Society 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bulman DE, Sadovnick AD, Ebers GC (1991) Age of onset in siblings concordant for multiple sclerosis. Brain 114: 937–950PubMedCrossRefGoogle Scholar
  2. Carswell R (1838) Pathological anatomy: illustrations of the elementary forms of disease. Longman, LondonGoogle Scholar
  3. Cruveilhier J (1835) Anatomie pathologique du corps humain. JB Balliere, ParisGoogle Scholar
  4. Dejong RN (1970) Multiple sclerosis: history, definition and general considerations. In: Vinken GW, Bryun PJ (eds) Handbook of clinical neurology. Elsevier, New York, pp 49Google Scholar
  5. Detels R, Visscher BR, Malmgren RM, Coulson AH, Lucia MV, Dudley JP (1977) Evidence for lower susceptibility to multiple sclerosis in Japanese Americans. Am J Epid 105: 303–310Google Scholar
  6. Duquette P, Pleines J, Girard M, Charest L, Senecal-Quevillon M, Masse C (1992) The increased susceptibility of women to multiple sclerosis. Can J Neurol Sci 19: 466–471PubMedGoogle Scholar
  7. Ebers GC, Bulman DE, Sadovnick AD, et al (1986) A population-based twin study in multiple sclerosis. N Engl J Med 315: 1638–1642PubMedCrossRefGoogle Scholar
  8. Ebers GC, Sadovnick AD (1994) Genetics of multiple sclerosis: a critical overview. J Neuroimmunology 54: 117–122CrossRefGoogle Scholar
  9. Ebers GC, Sadovnick AD, Risch NJ, the Canadian Collaborative Study Group (1995) Familial aggregation in multiple sclerosis is genetic. Nature 377: 150–151PubMedCrossRefGoogle Scholar
  10. Eichhorst H (1913) Multiple Sklerose und spastische Spinalparalyse. Med Klin 9: 1617–1619Google Scholar
  11. Finelli PF (1991) Conjugal multiple sclerosis: a clinical and laboratory study. Neurol 41: 1320–1321Google Scholar
  12. Firth D (1948) The case of Augustus d’Este. Cambridge University Press, LondonGoogle Scholar
  13. Gaudet JPC, Hashimoto L, Sadovnick AD, Ebers GC (1995) A study of birth order and multiple sclerosis in multiplex families. Neuroepidemiology 14: 188–192PubMedCrossRefGoogle Scholar
  14. Gronning M, Mellgren SI (1985) Multiple sclerosis in the two northernmost counties of Norway. Acta Neurologica Scandinavica 72: 321–327PubMedCrossRefGoogle Scholar
  15. Hader WJ, Feasby TE, Noseworthy JH, Rice GPA, Ebers GC (1985) Multiple sclerosis in Canadian native people. Neurol 35 [Suppl 1]: 300Google Scholar
  16. Hammond SR, McLeod JG, Millingen KS, et al (1988) The epidemiology of multiple sclerosis in three Australian cities: Perth, Newcastle and Hobart. Brain 111: 1–25PubMedCrossRefGoogle Scholar
  17. IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group (1995) Interferon beta-lb in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurol 45: 1277–1285CrossRefGoogle Scholar
  18. Jersild C, Svejgaard A, Fog T (1972) HLA antigens and multiple sclerosis. Lancet 1: 1240–1241PubMedCrossRefGoogle Scholar
  19. Kaufman MD (1992) Conjugal multiple sclerosis. Neurol 42: 1644–1645Google Scholar
  20. Marsden CD, Fowler TJ (1989) Demyelinating diseases of the central nervous system. In: Clinical neurology. Raven Press, New York, Chapter 16Google Scholar
  21. Noseworthy J, Paty DW, Wonnacott T, et al (1983) Multiple sclerosis after age 50. Neurol 33: 1537–1544CrossRefGoogle Scholar
  22. Popov VS (1983) Clinical picture and epidemiology of disseminated sclerosis. Zh Nevro- patol Psikhiatr 83: 1330–1334Google Scholar
  23. Poser CM, Paty DW, Scheinberg L, et al (1983) New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann Neurol 13: 227–231PubMedCrossRefGoogle Scholar
  24. Sadovnick AD, Baird PA, Ward RH (1988) Multiple sclerosis: updated risks for relatives. Am J Med Genet 29: 533–541PubMedCrossRefGoogle Scholar
  25. Sadovnick AD, Ebers GC (1993) Epidemiology of multiple sclerosis: a critical overview. Can J Neurol Sci 20: 17–29PubMedGoogle Scholar
  26. Sadovnick AD, Armstrong H, Rice GPA, et al (1993) A population-based twin study of multiple sclerosis in twins: update. Ann Neurol 33: 281–285PubMedCrossRefGoogle Scholar
  27. Sadovnick AD, Ebers GC, the Canadian Collaborative Study Group (1996) Basic, clinical and genetic epidemiology of MS. In: Abramsky O, Ovadia A (eds) Frontiers in multiple sclerosis: clinical research and therapy. Martin Dunitz Publications, London (in press)Google Scholar
  28. Schapira K, Poskanzer DC, Millar H (1963) Familial and conjugal multiple sclerosis. Brain 86: 315–332.PubMedCrossRefGoogle Scholar
  29. Schapiro RT (1994) Symptom management in multiple sclerosis. Demos Publications Inc, New YorkGoogle Scholar
  30. Schumacher GA, Beebe G, Kibler RF, et al (1965) Problems of experimental trials of therapy in multiple sclerosis. Report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann NY Acad Med 122: 552–568CrossRefGoogle Scholar
  31. Weinshenker BG, Bass B, Rice GP, et al (1989) The natural history of multiple sclerosis: a geographically-based study. I. Clinical course and disability. Brain 112: 133–146PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1997

Authors and Affiliations

  • A. Dessa Sadovnick
    • 1
  1. 1.Department of Medical GeneticsUniversity of British ColumbiaVancouverCanada

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