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Developmental and genetic regulation of programmed neuronal death

  • M. Weller
  • J. B. Schulz
  • U. Wüllner
  • P. A. Löschmann
  • T. Klockgether
  • J. Dichgans
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 50)

Summary

Apoptotic neuronal death is a key mechanism that regulates the elimination of neuronal precursor cells during the development of the mammalian brain. The principal action of neurotrophins such as nerve growth factor is probably the suppression of the preexistent machinery of programmed cell death that is readily activated in neurons deprived of neurotrophins. Potassium-mediated neuronal depolarization prolongs neuronal survival in vitro and has become a major model of examining neuronal apoptosis. Apoptosis induced by potassium deprivation triggers a lethal cascade of events that includes specific RNA and protein synthesis, induction of interleukin 1-converting enzyme-like protease activity, and generation of free radicals. Neuronal susceptibility to apoptosis is also regulated by the expression of bcl-2 family proteins. Current research focuses on the significance of these findings for the premature death of adult neurons in human neurodegenerative diseases.

Keywords

Nerve Growth Factor Programme Cell Death Cerebellar Granule Neuron Neuronal Precursor Cell Killer Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1997

Authors and Affiliations

  • M. Weller
    • 1
  • J. B. Schulz
    • 1
  • U. Wüllner
    • 1
  • P. A. Löschmann
    • 1
  • T. Klockgether
    • 1
  • J. Dichgans
    • 1
  1. 1.Department of NeurologyUniversity of Tübingen, Medical SchoolTübingenGermany

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