Summary
“TaClo”, (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) which is structurally very similar to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyri-dine), increases the sensitivity to apomorphine in aging rats after subchronic daily application (0.2 mg/kg i.p.) for 7 weeks. Nine weeks after the last treatment with TaClo, the running speed of the animals during spontaneous nocturnal activity was significantly diminished, and 9 months after the last injection rats developed a pronounced hypersensitivity to apomorphine (0.4 mg/kg s.c). TaClo, which can be readily produced from endogenous tryptamine and the non-natural aldehyde chloral, appears to be a drug that is able to induce a slowly-developing neurodegenerative process.
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© 1997 Springer-Verlag Wien
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Heim, C., Sontag, KH. (1997). The halogenated tetrahydro-β-carboline “TaClo”: A progressively-acting neurotoxin. In: Riederer, P., Calne, D.B., Horowski, R., Mizuno, Y., Poewe, W., Youdim, M.B.H. (eds) Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementa, vol 50. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6842-4_11
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DOI: https://doi.org/10.1007/978-3-7091-6842-4_11
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82898-4
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