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The halogenated tetrahydro-β-carboline “TaClo”: A progressively-acting neurotoxin

  • Christine Heim
  • K.-H. Sontag
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 50)

Summary

“TaClo”, (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) which is structurally very similar to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyri-dine), increases the sensitivity to apomorphine in aging rats after subchronic daily application (0.2 mg/kg i.p.) for 7 weeks. Nine weeks after the last treatment with TaClo, the running speed of the animals during spontaneous nocturnal activity was significantly diminished, and 9 months after the last injection rats developed a pronounced hypersensitivity to apomorphine (0.4 mg/kg s.c). TaClo, which can be readily produced from endogenous tryptamine and the non-natural aldehyde chloral, appears to be a drug that is able to induce a slowly-developing neurodegenerative process.

Keywords

Chloral Hydrate Injection Period Postsynaptic Dopamine Receptor Minute Observation Period Striatal Dopaminergic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1997

Authors and Affiliations

  • Christine Heim
    • 1
  • K.-H. Sontag
    • 1
  1. 1.Department of PsychiatryUniversity of GöttingenGöttingenGermany

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