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Medical Applications of Infrared Spectroscopy

  • Conference paper
Progress in Fourier Transform Spectroscopy

Part of the book series: Mikrochimica Acta Supplement ((MIKROCHIMICA,volume 14))

Abstract

Interest in the infrared spectral range for medical applications increases rapidly due to improvements in instrumentation and data processing. The use of lasers is fairly common for different tissue treatments, e.g. surgery. Optical imaging of tissue over greater distances, based on the relative transparency of biological tissue to short-wave near infrared radiation, is still in its infancy. Near infrared spectrometry is being investigated as a non-invasive clinical tool for improved understanding of in vivo processes. Some of the hottest research is carried out to obtain therapy-relevant biological parameters in human tumours. Of great interest is cerebral haemodynamics, as well as the intracellular reduction-oxidation (redox) level of cytochrome aa3, e.g in the brain of human neonates. Further studies cover the transcutaneous determination of important metabolites such as blood glucose. Mid and near infrared spectroscopy can also be exploited in combination with discrete sampling. Samples can be from the great variety of biofluids, such as whole blood or derived fluids, or for example, urinary calculi or tissue samples even at cellular level. IR spectroscopy can deliver reagent-free multicomponent assays. In particular, the quantitative analysis of blood substrates and its evaluation for application in the clinical laboratory have been undertaken by us. Extra-corporal sensors can be based on such technology. The prognosis for future development is that IR spectroscopy will play an important role in medical diagnostic instrumentation close to the patient.

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References

  1. H. M. Heise, Laboratoriumsmedizin 1991, 15, 470.

    CAS  Google Scholar 

  2. A. Hesse, G. Schrumpf, I. Schilling, Z. Urol. Nephrol. 1974, 67, 367.

    CAS  Google Scholar 

  3. M. Volmer, A. Bolck, B. G. Wohhers, A. J. de Ruiter, D. A. Doornbos, W. van der Slik, Clin. Chem. 1993, 39, 948.

    CAS  Google Scholar 

  4. F. F. Jöbsis, Science 1977, 198, 1264.

    Article  Google Scholar 

  5. J. S. Wyatt, D. T. Delpy, in: Imaging Techniques of the CNS of the Neonates Heidelberg New York Tokyo (J. Haddad, D. Christmann, J. Messer, eds.). Springer, Berlin Heidelberg, New York Tokyo, 1991.

    Google Scholar 

  6. C. E. Cooper, S. J. Matcher, J. S. Wyatt, M. Cope, G. C. Brown, E. M. Nemoto, D. T. Delpy, Biochem. Soc. Trans. 1994, 22, 974.

    CAS  Google Scholar 

  7. J. Wang, M. K. Ahmed, M. G. Sowa, H. H. Mantsch, Proc. SPIE 1994, 2089, 492.

    Article  Google Scholar 

  8. T. J. O’Leary, W. F. Engler, K. M. Ventre, Spectrosc. 1989 43, 1095

    Article  Google Scholar 

  9. P. T. T. Wong, B. Rigas, Appl. Spectrosc. 1990, 44, 1715

    Article  CAS  Google Scholar 

  10. D. R. Kodali, D. M. Small, J. Powell, K. Krishnan, Appl. Spectrosc. 1991 45, 1310.

    Article  CAS  Google Scholar 

  11. P. T. T. Wong, R. K. Wong, T. A. Caputo, T. A. Godwin, B. Rigas, Proc. Natl. Acad. Sci. USA 1991, 88 10988.

    Article  CAS  Google Scholar 

  12. D. Naumann, S. Keller, D. Helm, Ch. Schultz, B. Schräder, J. Mol. Struct. 1995, 347 399.

    Article  CAS  Google Scholar 

  13. S.-Y. Lin, R.-C. Liang, C.-H. Yang, H.-S. Hsu, A. T.-L. Lin, Anal. Meth. Instrum. 1993, 1, 191.

    CAS  Google Scholar 

  14. H. H. Mantsch, M. Jackson, J. Mol. Struct. 1995, 347, 187.

    Article  CAS  Google Scholar 

  15. M. G. Sowa, H. H. Mantsch, J. Mol. Struct. 1993, 300, 239.

    Article  CAS  Google Scholar 

  16. G. B. Christison, H. A. MacKenzie, Med. Biol. Eng. Comput. 1993, 31, 284.

    Article  CAS  Google Scholar 

  17. H. A. Mackenzie, G. B. Christison, P. Hodgson, D. Blanc, Sens. Actuators 1993, B 11, 213.

    Google Scholar 

  18. J. Wallon, S. H. Yan, J. Tong, M. Meurens, J. Haot, Appl. Spectrosc. 1994, 48, 190.

    Article  Google Scholar 

  19. Z. Ge, C. W. Brown, H. J. Kisner, Appl. Spectrosc. 1995, 49, 432.

    Article  CAS  Google Scholar 

  20. L. A. Cassis, R. A. Lodder, Anal. Chem. 1993, 65, 1247.

    Article  CAS  Google Scholar 

  21. H. H. Eysel, M. Jackson, H. H. Mantsch, G. T. D. Thomson, Appl. Spectrosc. 1993, 47, 1519.

    Article  CAS  Google Scholar 

  22. M. K. Ahmed, H. H. Mantsch, Proc. SPIE. 1994, 2089, 520.

    Article  Google Scholar 

  23. G. G. Guilbault, G. Palleschi, G. Lubrano, Biosens. Bioelectron. 1995, 10, 379.

    Article  CAS  Google Scholar 

  24. N. Kaiser, IEEE Trans. Biomed. Eng. 1979, 26, 597.

    Article  CAS  Google Scholar 

  25. K. Kajiwara, T. Uemura, H. Kishikawa, K. Nishida, Y. Hashi-guchi, M. Uehara, M. Sakakida, K. Ichinose, M. Shichiri, Med. Biol. Eng. Comput. 1993, 31, S17.

    Article  Google Scholar 

  26. R. Marbach, Meβverfahren zur IR-spektrometrischen Blutglucosebestimmung, Fortschr. Ber. VDI Ser. 8, Vol. 346, VDI Düsseldorf 1993.

    Google Scholar 

  27. H. M. Heise, R. Marbach, G. Janatsch, J. D. Kruse-Jarres, Anal. Chem. 1989, 61, 2009.

    Article  CAS  Google Scholar 

  28. G. Janatsch, J. D. Kruse-Jarres, R. Marbach, H. M. Heise, Anal. Chem. 1989, 61, 2016.

    Article  CAS  Google Scholar 

  29. H. M. Heise, R. Marbach, Th. Koschinsky, F. A. Gries, Appl. Spectrosc. 1994, 48, 85.

    Article  CAS  Google Scholar 

  30. H. M. Heise, A. Bittner, J. Mol. Struct. 1995, 348, 127.

    Article  CAS  Google Scholar 

  31. H. M. Heise, A. Bittner, J. Mol. Struct. 1995, 348, 21.

    Article  CAS  Google Scholar 

  32. P. Bhandare, Y. Mendelson, E. Stohr, R. A. Peura, Vib. Spectrosc. 1994, 6, 363.

    Article  CAS  Google Scholar 

  33. E. H. Korte A. Otto, Appl. Spectrosc. 1988, 42, 38.

    Article  CAS  Google Scholar 

  34. A. Bittner H. M. Heise Th. Koschinsky, F. A. Gries Mikrochim. Acta [Suppl] 1997, 14, 827.

    CAS  Google Scholar 

  35. K. H. Hazen, M. A. Arnold, G. W. Small, Appl. Spectrosc. 1994, 48, 477.

    Article  CAS  Google Scholar 

  36. A. Bittner, R. Marbach H. M. Heise, J. Mol. Struct. 1995, 349, 341.

    Article  CAS  Google Scholar 

  37. A. Bittner, Ph. D. Thesis, University of Essen, in preparation.

    Google Scholar 

  38. J. T. Kuenstner, K. H. Norris, W. F. McCarthy, Appl. Spectrosc. 1994, 48, 484.

    Article  CAS  Google Scholar 

  39. J. L. Gonczy, L. L. Gyarmati, in: Making Light Work: Advances in Near Infrared Spectroscopy (I. Murray, I. A. Cowe, eds.), VCH, Weinheim 1992.

    Google Scholar 

  40. M. Blazewicz, C. Paluszkiewicz, Proc. SPIE. 1992, 1575, 424.

    Article  Google Scholar 

  41. M. Hajek, Quat. Magn. Reson. Biol. Med. 1995, 2, 165.

    CAS  Google Scholar 

  42. G. Müller, (ed.). Medical Optical Tomography: Functional Imaging and Monitoring, Vol. 11, Society of Photo-Optical Instrumentation Engineers, Bellingham, Washington, 1993.

    Google Scholar 

  43. G. Mitic, J. Kölzer, J. Otto, E. Plies, G. Sölkner, W. Zinth, Appl. Optics 1994, 33, 6699.

    Article  CAS  Google Scholar 

  44. B. C. Wilson, E. M. Sevick, M. S. Patterson, B. Chance, Proc. IEEE 1992, 80, 918.

    Article  CAS  Google Scholar 

  45. J.-L. Boulnois, Lasers Med. Science 1986, 1, 47.

    Article  Google Scholar 

  46. M. H. Koelink, F. F. M. de Mul, J. Greve, R. Graaf, A. C. M. Dassel, J. A. Aarnoudse, Proc. SPIE 1991, 1431, 63.

    Article  Google Scholar 

  47. S. J. Matcher, M. Cope, D. T. Delpy, Phys. Med. Biol. 1994, 39, 2186.

    Google Scholar 

  48. B. C. Wilson, S. L. Jacques, IEEE J. Quant. Electron. 1990, 26, 2186.

    Article  Google Scholar 

  49. P. Kubelka, F. Münk, Z. Techn. Phys. 1931, 12, 593.

    Google Scholar 

  50. M. S. Patterson, B. C. Wilson, D. R. Wyman, Lasers Med. Science 1991, 6, 155.

    Article  Google Scholar 

  51. R. Marbach, H. M. Heise, Appl. Optics 1995, 34, 610.

    Article  CAS  Google Scholar 

  52. A. Bittner, S. Thomaßen, H. M. Heise, Mikrochim. Acta [Suppl.] 1997, 14, 429.

    Google Scholar 

  53. R. Marbach, Th. Koschinsky, F. A. Gries, H. M. Heise, Appl. Spectrosc. 1993, 47, 875.

    Article  CAS  Google Scholar 

  54. H. M. Heise, R. Marbach, Proc. SPIE 1994, 2089, 114.

    Article  Google Scholar 

  55. H. M. Heise, R. Marbach, Th. Koschinsky, F. A. Gries, Artif. Organs 1994, 18, 439.

    Article  CAS  Google Scholar 

  56. H. M. Heise, A. Bittner, in preparadon.

    Google Scholar 

  57. K. A. Martin, in: Making Light Work: Advances in Near Infrared Spectroscopy (I. Murray, I. A. Cowe, eds.), VCH, Weinheim, 1992.

    Google Scholar 

  58. J. M. Carney, W. Landrum, L. Mayes, Y. Zou, R. A. Lodder, Anal. Chem. 1993, 65, 1305.

    Article  CAS  Google Scholar 

  59. A. Villringer, J. Planck, C. Hock, L. Schleinkofer, U. Dirnagl, Neurosci. Lett. 1993, 154, 101.

    Article  CAS  Google Scholar 

  60. C. E. Elwell, H. Owen-Reece, M. Cope, A. D. Edwards, J. S. Wyatt, E. O. R. Reynolds, D. T. Delpy, Adv. Exp. Med. Biol. 1994, 345, 619.

    Article  CAS  Google Scholar 

  61. H.-U. Bucher, M. Wolf, M. Keel, K. von Siebenthal, G. Duc, Eur. J. Pediatr. 1994, 153, 123.

    Article  CAS  Google Scholar 

  62. F. Steinberg, M. Leßmann, C. Streffer, in: Oxygen Transport to Tissue XV (P. Vaupel, R. Zander, D. F. Bruley, eds.). Plenum, New York, 1994.

    Google Scholar 

  63. S. van Huffel, P. Casaer, P. van Mele, G. Willems, Proc. SPIE 1995, 2389, 743.

    Article  Google Scholar 

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Authors and Affiliations

  1. Institut für Spektrochemie und Angewandte Spektroskopie, Bunsen-Kirchhoff-Str. 11, D-44139, Dortmund, Federal Republic of Germany

    H. M. Heise

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  1. H. M. Heise
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Editors and Affiliations

  1. Department of Analytical Chemistry, University of Veszprém, Veszprém, Hungary

    János Mink

  2. Institute of Isotopes, Hungarian Academy of Sciences, Budapest, Hungary

    János Mink

  3. Central Research Institute of Chemistry, Hungarian Academy of Sciences, Budapest, Hungary

    Gábor Keresztury

  4. Institut für Analytische Chemie, Technische Universität Wien, Wien, Austria

    Robert Kellner

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© 1997 Springer-Verlag Wien

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Heise, H.M. (1997). Medical Applications of Infrared Spectroscopy. In: Mink, J., Keresztury, G., Kellner, R. (eds) Progress in Fourier Transform Spectroscopy. Mikrochimica Acta Supplement, vol 14. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6840-0_9

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  • DOI: https://doi.org/10.1007/978-3-7091-6840-0_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82931-8

  • Online ISBN: 978-3-7091-6840-0

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