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Brain Edema X pp 43–45Cite as

A Chronological Evaluation of Experimental Brain Infarct by Diffusion-Mapping and Magnetization Transfer Contrast Imaging

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Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 70))

Summary

Background and purpose:There is a complex system of evolving physiochemical processes in the ischemic brain. The evaluation of this chain of processes is a major challenge of recent stroke studies. Two magnetic resonance imaging techniques; diffusion-weighted (DW) and magnetization transfer contrast (MTC) imaging were introduced in experimental studies and were shown to have sensitivity for different stages of brain infarct.

Materials and methods:We used a reproducible middle cerebral artery (MCA) occlusion model in rat to examine infarcts of different time courses. Magnetic resonance T2-weighted (T2), DW, and MTC imaging were performed 3 h, 1 d, 3 d, 5 d, 7 d, 2 w, 3 w, and 4 w after MCA occlusion. Haematoxylin/eosin (HE) stained sections, which revealed sub regions within infarct lesions, were compared to T2, DW, diffusion-mapping and MTC-mapping images.

Results:On DW images 3 hours post occlusion lesions were detected as an area with high signal intensity, while T2 imaging does not raise significant contrast of the lesion at this early stage. Three sub regions of the lesion having different ADCs, are discernible on diffusion-mapping images from 1 day to 7 days. The decrease of MTC effect was measured within the infarct lesion from core to marginal zone, from 7 days to 4 weeks.

Conclusions:Diffusion-mapping imaging may help to examine brain infarction from 3 hours to 5 days. MTC imaging recognizes infarcts 7 days after the onset. Following this stage, MTC-mapping images may provide a quantitative method to assess infarct size.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Neurological Institute, Kyushu University, Faculty of Medicine, Fukuoka, 812-82, Japan

    Zsombor Kovács M.D., K. Ikezaki & M. Fukui

  2. Research Department, Diagnostic-Laboratory, Nihon Shering K.K., Japan

    M. Takahashi & J. Kawai

Authors
  1. Zsombor Kovács M.D.
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  2. K. Ikezaki
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  3. M. Takahashi
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  4. J. Kawai
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  5. M. Fukui
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Editor information

Editors and Affiliations

  1. Pediatric Neurosurgery, San Diego, CA, USA

    Hector E. James M.D.

  2. Division of Neurological Surgery, San Diego Medical Center, University of California, San Diego, CA, USA

    Lawrence F. Marshall M.D.

  3. Institut für Neurochirurgie, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany

    Hans J. Raulen (Prof. Dr.) (Prof. Dr.)

  4. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany

    Alexander Baethmann (Prof. Dr.) (Prof. Dr.)

  5. Neurological Surgery, Virginia Commonwealth University, Richmond, VA, USA

    Anthony Marmarou Ph.D.

  6. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    Umeo Ito M.D.

  7. Taubmann Health Care Center, The University of Michigan, Ann Arbor, MI, USA

    Julian T. Hoff M.D.

  8. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D.

  9. Department of Neurosurgery Medical Resarch Center, Polish Academy of Sciences, Warsaw, Poland

    Zbigniew Czernicki M.D., Ph.D.

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© 1997 Springer-Verlag

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Kovács, Z., Ikezaki, K., Takahashi, M., Kawai, J., Fukui, M. (1997). A Chronological Evaluation of Experimental Brain Infarct by Diffusion-Mapping and Magnetization Transfer Contrast Imaging. In: James, H.E., et al. Brain Edema X. Acta Neurochirurgica Supplements, vol 70. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6837-0_13

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  • DOI: https://doi.org/10.1007/978-3-7091-6837-0_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7418-0

  • Online ISBN: 978-3-7091-6837-0

  • eBook Packages: Springer Book Archive

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