Radiophysics, Radiobiology and the Gamma Knife

  • Jeremy C. Ganz


The purpose of this chapter is to relate the general knowledge, outlined in chapters 3, 4 and 5, to the particular conditions pertaining to Gamma Knife radiosurgery. This is a fascinating area, where new methods and findings are expanding and enhancing our knowledge, at an increasing rate. One particularly important new aspect that will be mentioned is research concerned primarily with the effects of single shot radiation on tissue. It has been mentioned (see chapter 1) that the term radiosurgery has unhappily become somewhat controversial. Nonetheless, all concerned with treatment techniques, which may loosely be said to fall under the generic term radiosurgery agree that extremely precisely localized, single treatment session radiation are two of the hallmarks of the techniques.


Dose Rate Arteriovenous Malformation Gamma Knife Gamma Knife Radiosurgery Proton Beam Therapy 
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Suggested Further Reading

  1. 1.
    Arndt J, Backlund E-O, Larsson B, Leksell L, Norén G, Rosander K, Rähn T, Sarby B, Steiner L, Wennerstrand J (1979) Stereotactic irradiation of intracranial structures: physical and biological considerations. INSERM Symposium 12: 81–92Google Scholar
  2. 2.
    Backlund E-O (1979) Stereotactic radiosurgery in intracranial tumours and vascular malformations. In: Krayenbühl H et al (eds) Advances and technical standards in neurosurgery, vol 6. Springer, Wien New York, pp 1–37Google Scholar
  3. 3.
    Larsson B (1992) Radiobiological fundamentals in radiosurgery. In: Steiner L (ed) Radiosurgery baseline and trends. Raven Press, New York, pp 3–14Google Scholar
  4. 4.
    Larsson B, Lidén K, Sarby B (1074) Irradiation of small structures through the intact skull. Acta Radiol 3: 512–534Google Scholar
  5. 5.
    Leksell L (1971) Stereotaxis and radiosurgery. An operative system. Ch C Thomas, Springfield, IGoogle Scholar
  6. 6.
    Van der Kogel AJ (1990) Central nervous system radiation injury in small animal models. In: Gutin PH, Leibel SA, Sheline GE (eds) Radiation injury to the nervous system. Raven Press, New York, pp 1–26Google Scholar
  7. 7.
    Withers HR, Peters LJ (1980) Biological aspects of radiation therapy. In: Fletcher GH (ed) Textbook of radiotherapy. Lea & Febiger, Philadelphia, pp 103–180Google Scholar

Copyright information

© Springer-Verlag/Wien 1997

Authors and Affiliations

  • Jeremy C. Ganz
    • 1
  1. 1.Department of NeurosurgeryUniversity School of MedicineGrazAustria

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