How can cerebral infarcts and hemorrhages lead to dementia?

  • F. Pasquier
  • Didier Leys
Conference paper


The incidence of new onset dementias is increased after stroke. The objective of this review is to investigate how cerebral infarcts and hemorrhages can lead to dementia. Stroke subtypes, total volume of cerebral lesion and functional tissue loss, and location of the lesions are the major determinant of dementia in stroke patients. The causal relationship between stroke and dementia is clear: (1) in young patients who are unlikely to have associated Alzheimer pathology; (2) when the cognitive functioning was normal before stroke, impaired immediately after, and does not worsen over time; (3) when the lesions are located in strategic areas; and (4) when a well-defined vasculopathy known to be associated with dementia is proven. However, white matter changes and associated Alzheimer pathology may also contribute to the dementia syndrome in stroke patients.


Stroke Patient Cerebral Infarct Vascular Dementia Cerebral Amyloid Angiopathy White Matter Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • F. Pasquier
    • 1
  • Didier Leys
    • 2
  1. 1.Department of Neurology, Memory UnitLille University HospitalLilleFrance
  2. 2.Department of Neurology, Stroke DepartmentRoger Salengro HospitalLilleFrance

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