Abstract
Neurotrophins, such as NGF, BDNF and NT-3 play a regulatory role on the function of microglial cells in vivo and in vitro, and the identification of new compounds with neurotrophic properties is becoming a new strategy for the prevention and/or treatment of neurodegenerative disorders. In this study we describe the use of two different models to demonstrate the ability of Cerebrolysin® to reduce microglial activation. The results of these in vitro and in vivo studies indicate that Cerebrolysin® might exert a neuroimmunotrophic activity reducing the extent of inflammation and accelerated neuronal death under pathological conditions such as those observed in neurodegenerative diseases.
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Álvarez, X.A. et al. (2000). Cerebrolysin® reduces microglial activation in vivo and in vitro: a potential mechanism of neuroprotection. In: Jellinger, K., Schmidt, R., Windisch, M. (eds) Advances in Dementia Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6781-6_30
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DOI: https://doi.org/10.1007/978-3-7091-6781-6_30
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83512-8
Online ISBN: 978-3-7091-6781-6
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